USC Roski Eye Institute director helps breakthrough glaucoma treatment come to the U.S. as Allergan receives FDA clearance for XEN® gel stent

Rohit Varma, MD, MPH, director of the USC Roski Eye Institute and dean of the Keck School of Medicine of USC, who led the work at USC, has called the Xen implantable device "a game changer" especially for those patients where refractory surgery treatments have failed to reduce intraocular pressure (IOP). It also is a breakthrough for patients with primary open angle glaucoma, pseudoexfoliative or pigmentary glaucoma with open angles that are unresponsive to maximum tolerated medical therapy. 

In 2015, Varma reported the results of his study participants. One year after the implant, Varma found eye pressure was reduced 44 percent and IOP medications were reduced 65 percent. Allergan has said the Xen stent will be available in the U.S. in early 2017.

"In our quest to prevent blindness and provide treatments that are less invasive and more effective, the Xen implantable device creates a new horizon for glaucoma patients," says Varma.  "We were excited to be part of the team where we created a drainage channel with the permanent yet flexible Xen implant and effectively lowered IOP and also reduced the drops needed for many patients."

According to the World Health Organization, glaucoma is the second leading cause of blindness worldwide and the American Academy of Ophthalmology reports that more than 3 million Americans have glaucoma but only half of those are diagnosed. Glaucoma can cause blindness when fluid builds up in the front part of the eye putting pressure on the optic nerve. Without releasing that pressure, damage to the optic nerve and potential blindness can occur.

"Glaucoma does not have to lead to blindness," added Varma. "Because there may be no symptoms and the disease progresses slowly, an annual eye exam, especially after the age of 50 that includes a dilated eye exam, will help prevent blindness with early detection and treatment."  

In addition to his clinical trial research with the Xen stent, Varma is recognized as one of the world's leading experts in population-based eye diseases. He has led several National Eye Institute-funded studies including the Prevalence of visual impairment (VI) and blindness doubling by 2050, the largest population-based study of adult Latinos and age-related macular degeneration (AMD) Los Angeles Latino Eye Study (LALES), the largest study of Chinese Americans and AMD Chinese American Eye Study (CHES) and the African-American Eye Disease Study (AFEDS). The USC Roski Eye Institute is ranked in the Top 2 of the nation's top grant recipients from the NEI and has achieved more than $32 million in annual grant funding.

Click here to watch Dr. Varma talk about his research on the Xen gel stent

Click here to learn more about the USC Roski Eye Institute

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SOURCE USC Roski Eye Institute