The Weizmann Institute of Science Selects Bruker GigaHertz NMR Technology to Enable Advanced Structural Biology Research

In the 1950s, one of the world's first high resolution NMR systems was conceived at Weizmann Institute researchers Alexander and Meiboom, and since then three generations of renowned Weizmann magnetic resonance researchers have played key roles in the development of NMR, EPR and MRI. Going forward, the focus of the Weizmann Institute in magnetic resonance research will be on biomolecular NMR and EPR research for future healthcare applications, metabolomics and preclinical research for cancer diagnostics and neurodegenerative diseases, as well as on advanced research on batteries and advanced materials.

Professor Gilad Haran, Dean of the Faculty of Chemistry at the Weizmann Institute of Science, commented: "In the last 2 years we hired 4 new faculty members specializing in the various branches of MR research. The new instruments will facilitate the research of this world-class group and of their more veteran peers, and will reinforce Weizmann's position as one of the premier centers in the world for MR research."

Werner Maas, Ph.D., the President of the Bruker BioSpin Magnetic Resonance Spectroscopy Division, added: "The adoption of the Aeon 1 GHz  NMR platform by the Weizmann Institute further validates this revolutionary technology and its impact on the research of structural biology and intrinsically disordered proteins. We are extremely pleased to partner with the Weizmann Institute and provide the research tools they need to advance scientific understanding of the bio-molecular processes of many diseases affecting people across the globe, as well as the understanding of advanced materials that will impact many emerging technologies."

The Aeon 1 GHz system incorporates the world's first shielded 1 GHz NMR magnet, as well as active refrigeration. Active shielding reduces the space volume occupied by the 5 Gauss stray field of this two-story magnet by more than one order of magnitude, and makes siting of next-generation Aeon 1 GHz magnets straight-forward. The Aeon magnet series features integrated  active refrigeration technology, which eliminates the need for liquid nitrogen, and brings liquid helium boil-off essentially to zero in normal operation. Bi-annual pulse-tube cooler maintenance can be done at field with minimal disruption and down-time.

The 263 GHz  DNP-NMR spectrometer takes advantage of the dramatic sensitivity enhancements enabled by Dynamic Nuclear Polarization (DNP). The system consists of an Avance™ III HD spectrometer, configured for solid-state NMR, combined with a high-power gyrotron microwave source and a specialized low-temperature DNP/NMR probe in an easy to use, integrated package.

The BioSpec® 150/11 is an ultra-high field MRI scanner for preclinical research on mice that will open new frontiers in molecular and microscopic imaging. Based on Bruker's proven 15 Tesla horizontal USR™ magnet technology, the system takes advantage of the high signal-to-noise ratio and enhanced contrast mechanisms at high field strength. Exploiting the novel 15 Tesla MRI CryoProbe™, the system enables new research on in vivo molecular events in cells.

About The Weizmann Institute of Science
The Weizmann Institute of Science is one of the world's leading multidisciplinary research institutions. The driving force and spirit that inspired its scientific activities was Dr. Chaim Weizmann, a world-renowned chemist who headed the World Zionist Movement for many years and served as the first president of the State of Israel.

Over the years, the Weizmann Institute has grown with the country and been the source of a number of Israeli milestones. These range from pioneering work in cancer research to building the county's first electronic computer and the first particle accelerator.

Other Institute firsts include the development and production of Israel's first ethical (original) drug, new computer languages, the solving of the three-dimensional structures of biological molecules involved in health and disease, and many more. The fields range from optics to genetics, from organ transplants from embryonic tissue to the creation of a nano-biological computer.

About Bruker Corporation
For more than 50 years, Bruker has enabled scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker's high-performance scientific research instruments and high-value analytical solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels. 

In close cooperation with our customers, Bruker is enabling innovation, productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy, nano-analysis and industrial applications, as well as in cell biology, preclinical imaging, clinical research, microbiology and molecular diagnostics. For more information, please visit:  www.bruker.com.

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