Study Updates, Market Activity, Preclinical Data, and Oral Presentations - Analyst Notes on Amicus, Conatus, Dicerna, Epizyme and Array

NEW YORK, July 3, 2014 /PRNewswire/ --

Today, Analysts Review released its analysts' notes regarding Amicus Therapeutics, Inc. (NASDAQ: FOLD), Conatus Pharmaceuticals Inc. (NASDAQ: CNAT), Dicerna Pharmaceuticals, Inc. (NASDAQ: DRNA), Epizyme, Inc. (NASDAQ: EPZM) and Array BioPharma, Inc. (NASDAQ: ARRY). Private wealth members receive these notes ahead of publication. To reserve complementary membership, limited openings are available at: http://www.analystsreview.com/4395-100free.

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Amicus Therapeutics, Inc. Analyst Notes
On June 30, 2014, Amicus Therapeutics, Inc. (Amicus) issued updates on its second Phase 3 study (Study 012) of migalastat monotherapy for Fabry patients with amenable mutations. According to the Company, the 18-month primary treatment period has completed with top-line data from Study 012 expected in Q3 2014. If successful, Study 012 will trigger the process for European regulatory approval of migalastat monotherapy. John F. Crowley, Chairman and CEO of Amicus commented, "We are very pleased to be advancing our Fabry monotherapy chaperone program into the final stages of drug development for Fabry patients with amenable mutations. Following on the heels of our recent positive results from our first Phase 3 registration Study 011, we are on track to report data in the third quarter of this year from Study 012, in which patients have volunteered to switch from ERT to our oral chaperone migalastat as their only therapy for Fabry disease." Crowley added, "We also plan to meet with the Food and Drug Administration in the fourth quarter of this year to discuss the data from both of our Phase 3 Fabry monotherapy studies, to determine the fastest U.S. registration pathway for migalastat." The full analyst notes on Amicus are available to download free of charge at:

http://www.analystsreview.com/Jul-03-2014/FOLD/report.pdf

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Conatus Pharmaceuticals Inc. Analyst Notes
On June 30, 2014, Conatus Pharmaceuticals Inc.'s (Conatus) stock increased 8.71% to end the day at $9.11, compared to the previous day's closing price at $8.38. The Company's stock climbed 47.17% over the past one trading month, compared to the Nasdaq Composite which rose 3.90% during the same trading period. The full analyst notes on Conatus are available to download free of charge at:

http://www.analystsreview.com/Jul-03-2014/CNAT/report.pdf

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Dicerna Pharmaceuticals, Inc. Analyst Notes
On June 30, 2014, Dicerna Pharmaceuticals, Inc. (Dicerna) announced the presentation of preclinical data demonstrating the promise of DCR-PH1, the Company's therapeutic candidate for the treatment of primary hyperoxaluria type 1 (PH1) - a rare inherited liver disorder that often results in progressive and severe kidney damage. The studies showed that DCR-PH1 provides long-term inhibition of HAO1, a gene implicated in the pathogenesis of PH1. In a genetically modified mouse model of PH1, researchers reported a 97% reduction of the HAO1 transcript in the liver following a single dose of DCR-PH1. "Physicians, patients and families managing PH1 currently have limited to no effective treatment for this severe and progressive disease," noted Craig B. Langman, M.D., Chair of the workshop and the Isaac A. Abt, M.D., Professor of Kidney Diseases, and Head, Kidney Diseases, at the Ann & Robert H. Lurie Children's Hospital of Chicago and the Feinberg School of Medicine of Northwestern University. "Based on these encouraging preclinical data, we look forward to beginning clinical trials to determine the potential role of DCR-PH1 in the treatment of PH1." The full analyst notes on Dicerna are available to download free of charge at:

http://www.analystsreview.com/Jul-03-2014/DRNA/report.pdf

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Epizyme, Inc. Analyst Notes
On June 10, 2014, Epizyme, Inc. (Epizyme) announced the acceptance of its abstract EPZ-6438 for oral presentation at the American Society of Hematology (ASH) Meeting on Lymphoma Biology. The presentation will be held from August 10 to 13, 2014 in Colorado Springs, Colorado. The presentation will encompass findings characterizing the activity of EPZ-6438, a small molecule inhibitor of EZH2, in pre-clinical models of non-Hodgkin lymphoma (NHL), both as a single agent and in combination with NHL standards of care. It will also highlight the early clinical experience from an ongoing Phase 1 study of EPZ-6438 (E7438) in patients with advanced malignancies, including NHL. The full analyst notes on Epizyme are available to download free of charge at:

http://www.analystsreview.com/Jul-03-2014/EPZM/report.pdf

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Array BioPharma, Inc. Analyst Notes
On June 30, 2014, Array Biopharma Inc.'s (Array) stock increased 7.29% to end the day at $4.56, compared to the previous day's closing price at $4.25. The Company's stock increased 8.57% over the past one trading month, compared to the Nasdaq Composite which rose 3.90% during the same trading period. The full analyst notes on Array are available to download free of charge at:

http://www.analystsreview.com/Jul-03-2014/ARRY/report.pdf

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