Promontory Therapeutics to Present Research on the Immunological Effects of PT-112 in Cancer Cell Mitochondria at SITC 2022

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Nov 07, 2022, 08:00 ET

NEW YORK, Nov. 7, 2022 /PRNewswire/ -- Promontory Therapeutics Inc., a clinical stage pharmaceutical company advancing small molecule immunotherapies in oncology, today announced that it will present data on lead therapeutic candidate, PT-112, and its immunological effects on cancer cell mitochondria. The presentation will take place at the 34th Annual Meeting of the Society for Immunotherapy of Cancer (SITC). SITC 2022 will take place virtually and in Boston on November 8-12.

Abstracts will be available for viewing on November 7 at 8am ET here.

Poster Presentation Details
Title: Immunologically relevant effects of PT-112 on cancer cell mitochondria
Presenter: Lorenzo Galluzzi, PhD
Abstract Number: 1118
Session Title: Immune-stimulants and immune modulators
Poster Presentation Sessions: Friday, November 11, 2022, 11:55 a.m. to 1:25 p.m. and 7:00 p.m. to 8:30 p.m. EST
Lead Author: Takahiro Yamazaki, PhD

For more information about PT-112 and Promontory Therapeutics' clinical pipeline visit www.PromontoryTx.com.

About PT-112
PT-112 is the first small-molecule conjugate of pyrophosphate in oncology, and possesses a unique pleiotropic mechanism of action that promotes immunogenic cell death (ICD), through the release of damage associated molecular patterns (DAMPs) that bind to dendritic cells and lead to downstream immune effector cell recruitment in the tumor microenvironment. PT-112 represents a highly potent inducer of this immunological form of cancer cell death. Further, PT-112 harbors a property known as osteotropism, or the propensity of the drug to reach its highest concentrations in certain areas of the bone, making it a candidate for treatment of patients with cancers that originate in, or metastasize to, the bone. The ﬁrst in-human study of PT-112 demonstrated an attractive safety proﬁle and evidence of long-lasting responses among heavily pre-treated patients and won "Best Poster" within the Developmental Therapeutics category at the ESMO 2018 Annual Congress. The combination Phase 1b dose escalation study of PT-112 with PD-L1 checkpoint inhibitor avelumab in solid tumors was reported in an oral presentation at the ESMO 2020 Virtual Congress. The Phase 1 study in patients with relapsed or refractory multiple myeloma presented at ASH is the third completed Phase 1 study of PT-112. Monotherapy Phase 2 development is ongoing in mCRPC, and now includes the Phase 2 proof of concept study in thymic epithelial tumors under the company's formal collaboration with the NCI. The PD-L1 combination Phase 2a study is ongoing in a dose confirmation cohort of non-small cell lung cancer (NSCLC) patients.

About Promontory Therapeutics
Promontory Therapeutics Inc. is a privately held, clinical stage pharmaceutical company focused on small molecule immunotherapy. The company's lead candidate, PT-112, is the first small molecule conjugate of pyrophosphate in oncology, and possesses a unique pleiotropic mechanism of action that promotes immunogenic cell death (ICD), through the release of damage associated molecular patterns (DAMPs) that bind to pattern recognition receptors on dendritic cells and promote the adaptive immune response in the tumor microenvironment. Clinical data generated across three Phase 1 studies have demonstrated single-agent anti-cancer activity and an attractive tolerability proﬁle, and three Phase 2 studies of PT-112 are underway. The company's research and development work has been conducted in the United States, Europe and Asia, along with a sub-license agreement for the development, commercialization and use of PT-112 in Greater China. The company also sponsors the ongoing clinical study of PT-112 in combination with the PD-L1 inhibitor avelumab under a collaboration agreement with Pﬁzer and Merck KGaA, Darmstadt, Germany (operating as EMD Serono in the US and Canada), and has an active Phase 2 trial underway with the NCI utilizing PT-112 in thymic epithelial tumors where PT-112 has received Orphan Drug designation.

To learn more about Promontory Therapeutics, visit the company's website here.

CONTACTS:

Promontory Therapeutics
Taylor B. Young
Senior Director, Strategic Development
Tel: +1 646 380 2441
Email: [email protected]

ICR Westwicke

Investors:
Stephanie Carrington
Tel: +1 646 277 1282
Email: [email protected]

Media:
Alexis Feinberg
Tel: +1 203-939-2225
Email: [email protected]

SOURCE Promontory Therapeutics Inc.