Plasmid DNA Manufacturing Market to Reach Valuation US$ 300 Mn by 2026

LOS ANGELES, March 11, 2020 /PRNewswire/ -- The global plasmid DNA manufacturing market is expected to reach valuation over US$ 300 million by 2026.

Acumen Research & Consulting, a global provider of market research studies, in a recently published report titled "Plasmid DNA Manufacturing Market (By Application: Gene Therapy, Vaccinology; By Disease: Infectious Disease, Cancer, Genetic Disorder: Research Institute , Biotech Companies; By Region: North America, Europe, Asia Pacific, Latin America, Middle East & Africa) - Global Industry Size, Share, Trends and Forecast 2019 - 2026".

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During the forecast period, the growing growth of the gene therapy market is likely to be seen in demand by plasmid DNA contract manufacturers. In addition, in recent years the demand for cell and gene therapy has increased substantially. According to recent findings from the Alliance of Regenerative Medicine (ARM), the funding of different cell and gene therapies was increased by over 75% year-on-year. Cell and gene therapies have taken place in a league of over 2,600 clinical trials reported to date. The growing demand for these therapies has given vector manufacturers new opportunities.

As a result of strategies such as market players working together, in Europe are expected to see significant growth in the plasmid DNA manufacturing market. For instance, in May 2018, Plasmid Factory GmbH & Co. KG has partnered with Vibalogics GmbH, Sirion-Biotech GmbH, and PROGEN for the development of vector adeno-associated virus (AAV). The goal of this collabration was to make the development of plasmid products simple and the study of recombinant AAVs to meet customers' requirements.

Advancing Plasmid Manufacturing at Aldevron

• Aldevron has developed plasmid DNA in 1998. They initially supplied research material and then extended to custom plasmid DNA for clinical, preclinical, and commercial purposes.
• The plasmids needed for viral vectors (AAV, lentivirus), DNA, CAR-T cell therapy, gene editing, cloning, DNA vaccines, personalised cell therapy and other applications have proved their expertise in Aldevron. Companies that seek novel products, including Sarepta for Duchenne's gene therapy and Genprex's lung cancer plasmid DNA, turn to Aldevron to be their plasma DNA suppliers.
• It can generate supercoiled, circular, minicroplasma, nanoplasmid and bacmid-plasma DNA and is capable of producing hundreds of grams per lot and hundreds of thousands of large-scale plasmid prepares per day. They will supply plasmid DNA in scientific, industrial and research applications.
• To meet different customer requirements, Aldevron manufactures plasmids at different service levels. For high-quality plasmid DNA, the research class is the fastest option. A cost-effective alternative to cGMP is GMP-SourceTM. Their cGMP service provides oversight and process management of highest quality and can support any demand, including parenteral administration.
• Aldevron also recently began supplying bulk off-shelf plasmids for AAV and lentiviral vector production. The immediate availability and costs for the manufacture of AAV and LV vectors are significantly reduced by the immediate use of these plasmids and also risk reduction is simplified by a reliable manufacturer of consistent high quality products. The plasmids inventory is also available at the level of research, GMP-SourceTM and cGMP.

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Key market players depend on approaches like mergers and acquisitions to boost their product portfolio. For instance, in 2016, the exclusive collaboration for Agilis experimental gene therapy drug AGIL-FA for the treatment of Friedreich's ataxia (FA) was entered into Agilis Biotherapeutics, LLC (AGILis) and Waisman Bia Manufacturing. Similarly, the Aldevron Antibody Development Platform in Germany revealed an expansion plan in March 2019. This proposal has increased the development and laboratory space of the current facility to approximately 4300 square feet.

The guidelines also consider specific organizational structures and compliance skills for early phase studies:

• Large companies in pharmaceutical/biotechnology that are likely to supply products in the market
• Start-up companies that grow and transition products to phase 1-2 and then to larger organizations or partners
• Limited trials for scientific publications by universities and funding agencies

Key Insights

• The North America Plasmid DNA Manufacturing market size was over 26 million USD in 2018 and is expected to witness the growth at a CAGR of around 22% from 2019 to 2026.
• The market in Asia Pacific is expected to witness faster growth, owing to factors such as increasing government expenditure on healthcare sector in order to facilitate R&D activities.
• The cancer market is expected to witness significant growth over the forecast period.

Market Segmentation

Market By Application

• Gene Therapy
• Vaccinology

Market By Disease

• Infectious Disease
• Cancer
• Genetic Disorder

Market By End use

• Research Institute
• Biotech Companies

Market By Region

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa

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