Over $3.7 million in NIH grants will fund research on impacts of climate change on HIV-related health outcomes

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Oct 18, 2023, 13:31 ET

NEW YORK, Oct. 18, 2023 /PRNewswire/ -- Two grants from the National Institute of Allergies and Infectious Diseases (NIAID), a four-year $3.2 million award and a 12-month $550,000 administrative supplement, will support innovative research to advance the understanding of how climate change and extreme weather influence HIV-related health outcomes around the world.

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A multidisciplinary team of researchers from the CUNY Institute for Implementation Science in Population Health (CUNY ISPH) at the CUNY Graduate School of Public Health and Health Policy (CUNY SPH), the University of California, San Francisco (UCSF), the University of California, Santa Barbara (UCSB) and the Icahn School of Medicine at Mount Sinai will examine the effects of extreme weather events, such as heavy rainfall, hurricanes and drought on short and long-term outcomes of more than two million people living with HIV who have enrolled in HIV care at clinics in 44 countries around the world.

"Most of the 37 million people living with HIV are on treatment, which requires continuous access to antiretroviral medications both to ensure a normal life expectancy and prevent onward transmission of the virus," says CUNY SPH Distinguished Professor of Epidemiology Dr. Denis Nash, executive director of CUNY ISPH and a principal investigator of both studies. "We know very little about the ways that extreme weather influences HIV outcomes and, by extension, its past and present influences on the trajectory of the HIV pandemic."

"Drought and extreme rainfall threaten agricultural yields and pastoral conditions, increasing food insecurity, undernutrition, migration and infrastructure erosion," says co-principal investigator Dr. Sheri D. Weiser, professor of medicine at UCSF and the director of the University of California's Center for Climate, Health and Equity. "These climate-related factors likely also increase the risk of poor clinical outcomes among people living with HIV."

Work on the four-year R01 award will combine data sources uniquely suited to characterize the influence of extreme weather on HIV care outcomes. The R01 will center on the global IeDEA cohort collaboration, which includes longitudinal data on more than two million people enrolling in HIV care since 2004 at more than 400 clinics in 44 countries. IeDEA data includes daily information on clinic visits, antiretroviral medication uptake and HIV-related laboratory tests that can be used to assess several key outcomes, including disruptions in HIV care and treatment, laboratory monitoring, HIV viral suppression and discontinuing care at a clinic.

The IeDEA cohort data will be combined with climate-related data sources, including high spatial resolution, daily data on temperature and rainfall data publicly available from UCSB's Climate Hazards InfraRed Precipitation/Temperatures with Station Data (CHIRPS/CHIRTS), which is based on weather-related satellite imagery and weather station data. With these combined data sources, the team will conduct in-depth analyses to produce some of the first longitudinal studies of the impact of extreme weather on HIV outcomes over time.

"This is an important and novel application of some of UCSB's flagship data resources," says Dr. Frank Davenport, a co-investigator and associate researcher at UCSB's Climate Hazards Center, which developed and curates CHRPS/CHIRTS.

The R01 project also includes a qualitative study among people living with HIV and key stakeholders in the Philippines and Rwanda – two countries vulnerable to and historically impacted by extreme weather events. The team will elucidate vulnerability and resilience factors as well as promising clinic and household adaptation strategies that are used in response to extreme weather events.

"This work will help provide important context and insights around the mechanisms by which extreme weather influences HIV outcomes, as well as approaches that are currently being used to adapt to climate change, both of which will be critical for our future work," says Weiser.

"The HIV pandemic is heavily concentrated in geographic regions of the world that are also most vulnerable to the impacts of extreme weather, creating the prospect that climate change may be a significant barrier to the goal of ending HIV/AIDS as a public health threat," says Dr. Andrew Maroko, director of the Geospatial Health Research Lab in the Institute for Health Equity Research at Icahn Mount Sinai. "Advances in spatial methods and geographic analysis have improved rapidly over the last few decades and are particularly well suited to this investigation. Because the study includes so many diverse geographic locations with data going back to 2004, we expect to gain insights about the specific types of locations where people living with HIV are most susceptible to specific types of extreme weather events."

With the 12-month administrative supplement to the NIH-funded Central Africa IeDEA project (U01AI096299, MPIs Nash, Anastos, Yotebieng), the CUNY team will create a new Climate and Health Scientific Interest Group (SIG) within the global IeDEA network. Many critical HIV care outcomes that are the focus of IeDEA's research, such as gaps in care, engagement in care, loss to care, viral suppression and drug resistance, remain unexplained by the universe of data currently collected within IeDEA. The new Climate and Health SIG within IeDEA will be a way to engage, share knowledge and support those among the 500+ investigators in the IeDEA network who also have an interest in climate and health research.

The project will also develop climate-related data resources specific to IeDEA to facilitate climate and health-focused research.

"We are trying to create a new research frontier within the IeDEA network focused on climate and HIV outcomes, which has further relevance for the larger group of IeDEA-engaged stakeholders, such as WHO, UNAIDS and PEPFAR, as well as for other health outcomes beyond HIV/AIDS," says Nash.

The few studies on the topic have suggested that extreme weather has a negative impact on exposures and HIV outcomes; however, most have been cross-sectional. Findings from the work of these new projects will leverage longitudinal data over a period of decades, which will better characterize true causal relationships. This, in turn, can inform strategies to help mitigate the impacts of climate change and extreme weather on HIV care outcomes and the trajectory of the HIV pandemic. The team also expects that the work will be relevant for other chronic health conditions that require continuous access to care and medications, such as hypertension and diabetes.

The team is currently recruiting for a full-time Postdoctoral Fellow to focus on climate and health research, as well as a full-time Project Manager, to join the project team.

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About CUNY SPH
The CUNY Graduate School of Public Health and Health Policy (CUNY SPH) is committed to promoting and sustaining healthier populations in New York City and around the world through excellence in education, research and service in public health and by advocating for sound policy and practice to advance social justice and improve health outcomes for all. sph.cuny.edu

About the CUNY ISPH
The CUNY Institute for Implementation Science in Population Health (ISPH) was founded on the notion that substantial improvements in population health can be efficiently achieved through better implementation of existing strategies, policies, and interventions across multiple sectors. With that in mind, we study how to translate and scale up evidence-based interventions and policies within clinical and community settings in order to improve population health and reduce health disparities. The CUNY ISPH is also part of the NIH funded Einstein, Rockefeller, CUNY Center for AIDS Research.

About UCSF
The University of California, San Francisco (UCSF) is exclusively focused on the health sciences and is dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It includes UCSF Health, which comprises three top-ranked hospitals, as well as affiliations throughout the Bay Area. Learn more at https://www.ucsf.edu.

About UCSB
The UCSB Climate Hazards Center, housed within the University Geography Department, is an alliance of multidisciplinary scientists utilizing climate and crop models, satellite-based earth observations, and socioeconomic data sets to predict and monitor droughts, food security, and health outcomes among the world's most vulnerable populations. Through partnerships with USAID, USGS, and the Famine Early Warning System Network (FEWS NET), the CHC provides early warning to save lives and secure livelihoods.

About the Mount Sinai Health System
Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, over 400 outpatient practices, nearly 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. For more information, visit https://www.mountsinai.org or find Mount Sinai on Facebook, Twitter and YouTube.

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