New Study Reviews Undertreated Side Effect From Cancer Treatment And Recommendations For Managing Symptoms

Hand-Foot-Skin Reaction, a Painful Skin Condition Affects Two-Thirds of Patients Taking a Treatment for Gastrointestinal Cancers

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Montefiore Health System

Jun 01, 2015, 09:46 ET

NEW YORK, June 1, 2015 /PRNewswire-USNewswire/ -- Investigators from Montefiore Einstein Center for Cancer Care have announced new findings from an extensive literature review published today in the Annals of Oncology. This review found that side effects from regorafenib like redness and swelling may be undertreated. Also included are recommendations from experienced oncologists and dermatologists that outline supportive measures to help prevent or reduce Hand-Foot-Skin-Reaction (HFSR) symptoms. Better management of HFSR may allow patients to continue to take regorafenib at an optimal dose.

Almost two thirds of patients who take regorafenib, a medication used to treat certain colorectal cancers and inoperable stomach cancers, experience HFSR symptoms, but this condition, characterized by painful red swelling of the hands and feet, can sometimes be effectively managed without necessitating a change in cancer therapy. Approximately 40,000 patients worldwide are prescribed regorafenib, a treatment option for patients whose cancer has stopped responding to their current chemotherapy.

"Our review revealed a lack of articles about managing regorafenib-related HFSR, which was surprising given the frequency of this condition," said lead author Beth McLellan, M.D., director, Oncodermatology, Division of Dermatology, Montefiore Einstein Center for Cancer Care and assistant professor of Dermatology at Albert Einstein College of Medicine. "The goal of these recommendations is to highlight interdisciplinary practices healthcare providers can use to help recognize and manage this debilitating side effect so patients can more comfortably adhere to life-saving or prolonging treatments."

"There are so many side effects from chemotherapy that patients are warned about," said Dr. McLellan. "Often patients are surprised by the severity and discomfort of side effects in the skin such as HFSR and they may not realize there are treatment options available. Our goal is to encourage patients to express concerns about these side effects as we can often help to improve symptom management and decrease discomfort."

Montefiore healthcare professionals also encourage patients to discuss activities that may place stress on the hands and feet, such as heavy lifting or long walks, especially during the first month of treatment, to reduce risk of blistering.

The article is titled, "Regorafenib-associated hand–foot skin reaction: practical advice on diagnosis, prevention and management." The lead author on the study is Dr. McLellan and the co-authors are Fortunato Ciardiello, MD, PhD, Full Professor of Medical Oncology at Seconda Università degli studi di Napoli, Napoli, Italy; Mario E. Lacouture, M.D., at MemorialSloan Kettering; Siegfried Segaert, M.D., Ph.D. Professor of Dermatology Department of Dermatology at University Hospitals Leuven and KU Leuven.

This work was supported by Bayer HealthCare Pharmaceuticals which provided financial support for editorial assistance by Succinct Medical Communications, but was not otherwise involved in the literature review, content development, or advice provided in the article.

About Montefiore Health System
Montefiore is a premier academic health system and the University Hospital for Albert Einstein College of Medicine. Combining nationally-recognized clinical excellence with a population health perspective that focuses on the comprehensive needs of the communities it serves, Montefiore delivers coordinated, compassionate, science-driven care where, when and how patients need it most. Montefiore consists of eight hospitals and an extended care facility with a total of 2,747 beds, a School of Nursing, and state-of-the-art primary and specialty care provided through a network of more than 150 locations across the region, including the largest school health program in the nation and a home health program. The Children's Hospital at Montefiore is consistently named in U.S. News' "America's Best Children's Hospitals." Montefiore's partnership with Einstein advances clinical and translational research to accelerate the pace at which new discoveries become the treatments and therapies that benefit patients. The health system derives its inspiration for excellence from its patients and community, and continues to be on the frontlines of developing innovative approaches to care. For more information please visit http://www.montefiore.org. Follow us on Twitter; like us on Facebook; view us on YouTube.

SOURCE Montefiore Health System