New Award-Winning Infertility Research Addresses IVF Success, Embryo Transfer, Donor Egg, Genetic Testing, and Early Pregnancy

BASKING RIDGE, N.J., Oct. 17, 2016 /PRNewswire/ -- Reproductive Medicine Associates of New Jersey (RMANJ), a world-renowned leader in the field of infertility treatment and research, will present 28 clinical abstracts including two award-winner papers authored by Nathan Treff, PhD and Marie D. Werner, MD, FACOG, TS (ABB) at the American Society for Reproductive Medicine (ASRM) 2016 Scientific Congress & Expo this week in Salt Lake City, Utah.

The RMANJ team will also have 14 oral presentations and 14 poster presentations covering a wide array of emerging and important topics including embryology, genetics, embryo biopsy, and donor egg cycles.

"I am incredibly proud of our RMANJ team and what we've accomplished in the last year. Our research is helping to lead the way across a number of clinical, scientific, and practical issues facing our infertility specialty," said Richard T. Scott, Jr., MD, FACOG, ALD/HCLD, laboratory director and a founding partner of RMANJ. "From Dr. Werner's research on next generation sequencing (NGS) to Dr. Hong's study on "natural IVF" which shows no gains in success rates versus traditional IVF, our efforts address the pressing questions that affect providers and patients alike."

Dr. Werner commented on her study titled "Targeted NGS provides accurate predictions of segmental (SEG) aneuploidy and prognosticates reduced reproductive potential of the human blastocyst." "Next generation sequencing has now been applied clinically for Comprehensive Chromosome Screening (CCS)," said Dr. Werner. "The team at RMANJ is excited to be the recipient of the SRBT award recognizing the next advancement in genetic screening of embryos." 

To aid in the development of reproductive-associated biomarker screening technology, Dr. Treff's research, titled "Comprehensive chromosome screening and gene expression analysis from the same biopsy", validates a new method for simultaneous comprehensive chromosome screening (CCS) and RNA analysis to be evaluated from the same trophectoderm biopsy.

Dr. Treff noted that "the research team at RMANJ is excited to receive recognition from our peers at ASRM for our work towards new biomarkers of embryonic reproductive potential." "Unlocking the potential of the transcriptome could allow for more effective treatment of infertility," he continued, "and we anticipate that our novel approach will help us reach this milestone in the very near future."

Research from RMANJ's newest physician, Daniel J. Kaser, MD, FACOG has been nominated for a 2016 ASRM Prize Paper - a highly coveted and prestigious award. The research titled, "Randomized Controlled Trial of Low (5%) vs. Ultralow (2%) Oxygen Tension for In Vitro Development in Human Embryos" was completed while Dr. Kaser was a fellow at Brigham and Women's Hospital in Boston, MA. Winners will be announced on Wednesday, October 19, 2016. Scott Morin, a second year fellow at RMANJ, and Xin Tao of RMANJ's Foundation for Embryonic Competence will also be receiving awards at ASRM for their research efforts.

For a full list of abstracts, visit www.rmanj.com.

• "NATURAL IS NOT BETTER: GONADOTROPIN STIMULATION DOES NOT INCREASE ANEUPLOIDY OR DIMINISH IMPLANTATION RATES OF EUPLOID EMBRYOS"

• "DOES STRESS AFFECT IN VITRO FERTILIZATION (IVF) OUTCOME?"

• "A 'FOLLICLE-STIMULATING HORMONE BOOST' ADMINISTERED AT THE TIME OF HUMAN CHORIONIC GONADOTROPIN TRIGGER DOES NOT AFFECT IVF CYCLE OUTCOMES"

• "INTERACTION OF UTERINE NATURAL KILLER CELL IMMUNOGLOBULIN RECEPTOR (KIR) HAPLOTYPE AND TROPHOBLASTIC HLA-C LIGAND INFLUENCES RISK OF PREGNANCY LOSS: A RETROSPECTIVE ANALYSIS OF DIRECT EMBRYO GENOTYPING DATA"

• "TARGETED NGS PROVIDES ACCURATE PREDICTIONS OF SEGMENTAL (SEG) ANEUPLOIDY AND PROGNOSTICATES REDUCED REPRODUCTIVE POTENTIAL OF THE HUMAN BLASTOCYST"

• "MOSAICISM DETECTION BY QPCR VERSUS NGS BASED CCS"

• "SINGLE EMBRYO TRANSFER (SET) FOLLOWING COMPREHENSIVE CHROMOSOME SCREENING (CCS) IS MORE COST EFFECTIVE THAN UNSCREENED SEQUENTIAL SET"

• "OBSTETRIC OUTCOMES FOLLOWING FROZEN EMBRYO TRANSFER (FET) IN PATIENTS WITH AN ENDOMETRIAL THICKNESS MEASURING <7MM"

• "ELEVATED ANTIMULLERIAN HORMONE (AMH) DOES NOT FALSELY PREDICT OVARIAN RESPONSE IN PATIENTS WITH ADVANCED STAGE ENDOMETRIOSIS"

• "ENMOTION: EMBRYO'S NATURAL MOTION. BLASTULATION IS NOT DIFFERENT BETWEEN STATIC AND DYNAMIC CULTURE SYSTEMS"

• "ASSESSMENT OF THE EMBRYO TRANSFER CATHETER MICROBIOME AFTER EUPLOID BLASTOCYST TRANSFER IS NOT PREDICTIVE OF SUSTAINED IMPLANTATION"

• "IMMEDIATE AMBULATION AFTER EMBRYO TRANSFER HAS NO EFFECT ON ONGOING PREGNANCY RATES IN FRESH OR FROZEN IVF CYCLES WITH OR WITHOUT COMPREHENSIVE CHROMOSOMAL SCREENING"

• "LIVE BIRTH RATE FOLLOWING EMBRYO TRANSFER IS SIGNIFICANTLY INFLUENCED BY THE PHYSICIAN PERFORMING THE TRANSFER: DATA FROM 2707 EUPLOID BLASTOCYST TRANSFERS BY 11 PHYSICIANS"

• "FMR1 PREMUTATION CARRIERS ARE PREDISPOSED TO POOR OVARIAN RESPONSE, BUT EXHIBIT NO DIMINUTION IN OVERALL OOCYTE EFFICIENCY, BLASTULATION RATE OR INCREASE IN ANEUPLOIDY"

• "TROPHECTODERM BIOPSIES WITH HIGHER ESTIMATED CELLULARITY INCREASE RISK OF PREGNANCY LOSS AND MONOZYGOTIC TWINNING"

• "REDUCED DEVELOPMENTAL EFFICIENCY OF VITRIFIED DONOR OOCYTES (DOS) IS EXPLAINED BY WIDE VARIATION IN FERTILIZATION SUCCESS"

• "SEQUENTIAL (SEQ) VS. MONOPHASIC (MONO) MEDIA IMPACT TRIAL (SUMMIT): ANALYSIS OF DELIVERY OUTCOMES AMONGST EMBRYOS CULTURED IN DIFFERENT MEDIA FORMULATIONS"

• "A TRINARY SCORING SYSTEM GENERATED BY THE EEVA<SUP>TM</SUP> TEST'S TIME-LAPSE MICROSCOPY (TLM) SOFTWARE DOES NOT PREDICT PLOIDY AT THE BLASTOCYST STAGE OR DELIVERY OF EUPLOID EMBRYOS"

• "PROSPECTIVE RANDOMIZED AND BLINDED COMPARISON OF NGS CCS PLATFORMS"

• "MITOCHONDRIAL DNA CONTENT IS INCREASED IN THE ANEUPLOID MOUSE BLASTOCYST"

• "MATERNAL WHOLE EXOME SEQUENCING REVEALS CANDIDATE PATHWAYS FOR EMBRYONIC ANEUPLOIDY RISK"

• "COMPREHENSIVE CHROMOSOME SCREENING AND GENE EXPRESSION ANALYSIS FROM THE SAME BIOPSY"

• "LEVELS OF TROPHECTODERM MITOCHONDRIAL DNA DO NOT PREDICT THE REPRODUCTIVE POTENTIAL OF HUMAN BLASTOCYSTS"

• "EARLY SUBCHORIONIC BLEED (SCB) IN ASSISTED REPRODUCTIVE TECHNOLOGY (ART) PREGNANCIES DOES NOT INFLUENCE BIRTH WEIGHT"

• "PATERNAL AGE DOES NOT IMPACT ANEUPLOIDY RATES AS DETERMINED BY COMPREHENSIVE CHROMOSOME SCREENING (CCS) IN DONOR OOCYTE CYCLES"

• "(DONOR) AGE IS ONLY A NUMBER: A COMPARISON OF OOCYTE DONORS"

• "SPECIAL RESEARCH PRESENTATION: GENE VARIANTS IN AURORA KINASE COULD BE PREDICTIVE OF MATERNAL OOCYTE ANEUPLOIDY"

• "REPEAT IN VITRO FERTILIZATION SUCCESS RATES ARE LOWER IN PATIENTS WHO DELIVER VIA CESAREAN SECTION WHEN USING EMBRYOS FROM THE SAME COHORT"

ABOUT REPRODUCTIVE MEDICINE ASSOCIATES OF NEW JERSEY
The experts at RMANJ offer IVF delivery rates of 63.2 percent in women under 35 (n=886) and well above the US average*. Since 1999, they have helped bring nearly 40,000 babies to loving families. RMANJ has 25 physicians and 10 locations in New Jersey: Basking Ridge, Eatontown, Englewood, Freehold, Hamilton, Morristown, Somerset, Springfield, West Orange, and its newest location in Marlton, New Jersey. For more information, please call 973-656-2089 or visit www.rmanj.com.

RMANJ pioneered and successfully implemented a cutting-edge technology known as Select Comprehensive Chromosome Screening (SelectCCS) to more accurately detect healthy embryos that has led to successful pregnancies and ultimately healthy babies. SelectCCS is owned and operated by the Foundation for Embryonic Competence (www.feclabs.org) and offers advanced embryo selection with extreme accuracy by detecting and avoiding use of embryos with chromosomal abnormalities prior to transfer and pregnancy.

*SART 2014; Cumulative Outcome per Intended Retrieval; Preliminary Chance of Live Birth per Cycle. Please note: A comparison of clinic success rates may not be meaningful because a patient's medical characteristics, treatment approaches and entrance criteria for assisted reproductive technology (ART) may vary from clinic to clinic. Visit www.sart.org to learn more.

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SOURCE Reproductive Medicine Associates of New Jersey (RMANJ)

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