Natural Cycles & UCL Release Groundbreaking Data In Women's Reproductive Health

STUDY REVEALS COMMON MISCONCEPTION IN MENSTRUAL CYCLE

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Sep 12, 2019, 08:07 ET

NEW YORK, Sept. 12, 2019 /PRNewswire/ -- Contraceptive App Natural Cycles and UCL release new study revealing that, contrary to popular belief, menstrual cycles are considerably varied with only 13% of women having cycles that last 28 days.

The study published in Nature Digital Medicine is one of the biggest overviews of menstrual cycles to date and analyzed data of over 600,000 menstrual cycles and 124,648 women from Sweden, USA and the UK and could help couples better understand when pregnancy is likely and unlikely to occur.

Researchers set out to investigate menstrual cycle characteristics and associations with age, BMI and body temperatures. The findings show an average cycle length is 29.3 days and only around 13% of cycles are 28 days in length. Across the study, 65% of women had cycles that lasted between 25 and 30 days.

The menstrual cycle begins and ends with menstrual bleeding and is divided by ovulation into two phases: the follicular and luteal phases. Researchers found the average follicular phase length was 16.9 days and the average luteal phase length was 12.4 days. The average cycle length decreased by 0.18 days and average follicular phase length decreased by 0.19 days per year of age from 25 to 45 years. The average variation of cycle length for obese women was 0.4 days or 14% higher. Cycle length variability was observed to a lesser extent in non-obese and underweight women.

Professor Joyce Harper (UCL Institute for Women's Health) said:
Our study is unique in analyzing over half a million cycles and re-writing our understanding of the key stages. Traditionally studies have concentrated on women who have approximately 28-day cycles and these studies have formed our understanding of the menstrual cycle. For the first time our study shows that few women have the textbook 28-day cycle, with some experiencing very short or very long cycles. We also demonstrate that ovulation does not occur consistently on day 14 and therefore it is important that women who wish to plan a pregnancy are having intercourse on their fertile days. In order to identify the fertile period, it is important to track other measures such as basal body temperature as cycle dates alone are not informative.

Dr Simon Rowland, Head of Medical Affairs at Natural Cycles, said:
Given the variations in cycle length and follicular phase length that we have described, especially for cycles outside the average range (25-30 days), an individualized approach to identify the fertile window should be adopted. Apps giving predictions of fertile days based solely on cycle dates could completely miss the fertile window and it is therefore unsurprising that several studies have shown that calendar apps are not accurate in identifying the fertile window. Besides the potential benefits to the individual, fertility awareness apps and the associated databases of fertility data provide a unique opportunity to examine a large number of menstrual cycles in order to improve understanding.

Data was collected from women using the app between September 2016 and February 2019 aged 18 to 45 and had a BMI between 15 and 50 and had not been using hormonal contraception within the 12 months prior to registration. Users who stated at registration that they had a pre-existing medical condition (polycystic ovarian syndrome, hypothyroidism or endometriosis) or who had menopausal symptoms were excluded.

The authors note the main limitation of this study is that the study population is derived solely from users of the app who may not be representative of the wider population. In particular, only 8% of women in our study were obese compared to 15% of women in the general population.

Professor Harper added:
The widespread use of mobile phone apps for personal health monitoring is generating large amounts of data on the menstrual cycle. Provided that the real-world data can be validated against traditional clinical studies done in controlled settings, there is enormous potential to uncover new scientific discoveries. This is one of the largest ever analyses of menstrual cycle characteristics. These initial results only scratch the surface of what can be achieved. We hope to stimulate greater interest in this field of research for the benefit of public health.

About Natural Cycles:
Natural Cycles was founded in June 2013 by former CERN physicist Dr Elina Berglund and her husband Dr Raoul Scherwitzl, who also has a background in physics.

Natural Cycles is an effective, natural method of contraception that is delivered in the form of an app. It uses a smart algorithm that is sensitive to subtle patterns in a woman's cycle to determine daily fertility, based on basal body temperature and period data. Natural Cycles is 93% effective with typical use, which means that 7 women out of 100 get pregnant during 1 year of use. Natural Cycles is the only app of its kind to be available in Europe and the US for use as a contraceptive. The app can also be used to help plan a pregnancy when the time is right.

Natural Cycles' mission is to pioneer women's health with research and passion, by empowering every woman with the knowledge she needs to be in charge of her health. Natural Cycles is headquartered in Sweden and has operations in the United States, Germany, Switzerland and the United Kingdom.