Metastatic HER2-Positive Breast Cancer Market to Grow by 2032 at a 5.2% CAGR | DelveInsight

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Nov 29, 2023, 17:01 ET

The total metastatic HER2-positive breast cancer market size in the 7MM was estimated to be nearly USD 2.6 billion in 2022, which is expected to show positive growth by 2032. In addition, the market size is anticipated to increase in the coming years due to the launch of novel therapies such as SYD985 (trastuzumab duocarmazine): (Byondis), Giredestrant (Roche), ARX788 (Ambrx), Zanidatamab (Zymeworks/Jazz Pharmaceuticals), and others along with the increase in R&D activities and rising healthcare spending across the globe.

LAS VEGAS, Nov. 29, 2023 /PRNewswire/ -- DelveInsight's Metastatic HER2-Positive Breast Cancer Market Insights report includes a comprehensive understanding of current treatment practices, metastatic HER2-positive breast cancer emerging drugs, market share of individual therapies, and current and forecasted market size from 2019 to 2032, segmented into 7MM [the United States, the EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan].

Key Takeaways from the Metastatic HER2-Positive Breast Cancer Market Report

As per DelveInsight analysis, the total incident population of HER2-positive breast cancer in the seven major markets was nearly 100K cases in 2022. The cases in the 7MM are expected to increase during the forecast period, i.e., 2023–2032, reports DelveInisght.
Leading metastatic HER2-positive breast cancer companies such as Byondis, Roche, Ambrx, Zymeworks, Jazz Pharmaceuticals, Pfizer, and others are developing novel metastatic HER2-positive breast cancer drugs that can be available in the metastatic HER2-positive breast cancer market in the coming years.
The promising metastatic HER2-positive breast cancer therapies in the pipeline include SYD985 (trastuzumab duocarmazine), Giredestrant, ARX788, Zanidatamab, IBRANCE (palbociclib), and others.

Discover which therapies are expected to grab the major metastatic HER2-positive breast cancer market share @ Metastatic HER2-Positive Breast Cancer Market Report

Metastatic HER2-Positive Breast Cancer Overview

In 2022, HER2-positive breast cancer affected nearly 100,000 individuals in the seven major markets. It is anticipated that the number of cases in the 7MM will rise during the forecast period from 2023 to 2032. The HR+/HER2+ breast cases were highest in the United States, accounting for ~32K cases. Most cases of HER2-positive breast cancer occur in people between 40 and 60 in the United States, accounting for ~52% of total cases in 2022.

The metastatic HER2-positive breast cancer market report proffers epidemiological analysis for the study period 2019–2032 in the 7MM segmented into:

Total Incident Cases of HER2-Positive Breast Cancer
Hormonal Status of HER2-Positive Breast Cancer
Age-Specific Cases of HER2-Positive Breast Cancer
Stage-Specific Cases of HER2-Positive Breast Cancer
Line-wise Metastatic Cases of HER2-Positive Breast Cancer

Metastatic HER2-Positive Breast Cancer Treatment Market

The primary modalities for treating metastatic breast cancer are targeted therapy and hormonal therapy. The selection of first-line treatment is contingent upon the receptor status, specifically pertaining to estrogen, progesterone, and HER2 receptors. In instances where both HER2 and estrogen receptors exhibit positivity, the initial therapeutic approach may encompass hormonal therapy, HER2-targeted therapy, or a combined regimen of both modalities.

In the treatment regime of metastatic HER2-positive breast cancer, HERCEPTIN and PERJETA have maintained their status as the standard of care for a decade paving way for continuous research and bringing innovation to the domain. Although the advent of biosimilars has notably impacted the revenue of HERCEPTIN, Roche has responded by introducing subcutaneous versions of both HERCEPTIN and PERJETA to counteract biosimilar competition and improve patient adherence in comparison to other IV formulations. In the second-line treatment setting, KADCYLA has held a prominent position. However, with the launch of ENHERTU and its subsequent inclusion in the NCCN and ESMO guidelines, there has been a swift transition in patient preferences and a notable shift in the treatment landscape. Before ENHERTU, Seagen's Tyrosine Kinase Inhibitor, TUKYSA was also launched in the same line. As per DelveInsight's recent analysis, the metastatic HER2-positive treatment market is anticipated to experience gradual growth. This is attributed to the presence of established blockbuster HER2-targeting therapies, including the recently launched ENHERTU, which continues to be the preferred choice for physicians due to its demonstrated strong efficacy and substantial benefits. However, as tailwinds for market growth, several promising therapies are currently in development and expected to enter the market by 2032, including SYD985 (Byondis), Zanidatamab (Zymeworks/Jazz Pharmaceuticals), ARX788 (Ambrx), and others. Notably, these therapies are strategically designed for later-line settings, particularly targeting heavily treated patients.

To know more about metastatic HER2-positive breast cancer treatment paradigm, visit @ Metastatic HER2-Positive Breast Cancer Management

Metastatic HER2-Positive Breast Cancer Therapies and Key Companies

SYD985 (trastuzumab duocarmazine): Byondis
Giredestrant: Roche
ARX788: Ambrx
Zanidatamab: Zymeworks/Jazz Pharmaceuticals
IBRANCE (palbociclib): Pfizer

Learn more about expected uptake of emerging drugs @ Drugs for Metastatic HER2-Positive Breast Cancer Treatment

Metastatic HER2-Positive Breast Cancer Market Dynamics

The metastatic HER2-positive breast cancer treatment landscape has been revolutionized by the development of targeted therapies, such as trastuzumab (Herceptin), pertuzumab (Perjeta), and ado-trastuzumab emtansine (Kadcyla). Ongoing research is expected to boost the market growth of targeted therapies or combinations that are expected to provide improved efficacy and reduced side effects.The integration of immunotherapeutic approaches, such as checkpoint inhibitors, in combination with existing HER2-targeted therapies, could be an avenue for further exploration.

Moreover, advances in understanding the molecular and genetic makeup of tumors may lead to the identification of specific biomarkers that can predict treatment response. This could enable more precise and personalized treatment strategies for individuals with metastatic HER2-positive breast cancer. Additionally, ongoing and upcoming clinical trials play a crucial role in shaping the future of cancer treatment. Collaborative efforts between pharmaceutical companies, research institutions, and healthcare providers are likely to contribute to the development of innovative therapies and treatment modalities.

Furthermore, the focus on patient-centered care is likely to continue, with an emphasis on improving quality of life and managing treatment-related side effects. Supportive care interventions and holistic approaches to patient well-being may become integral parts of the overall treatment strategy. As more patients are treated and monitored, real-world evidence and data analytics will play a significant role in evaluating the effectiveness of treatments in diverse patient populations. This can inform treatment decisions and contribute to a more comprehensive understanding of the disease.

However, the metastatic HER2-positive breast cancer market faces several formidable barriers to evolution in the coming years, hindering advancements in treatment and patient outcomes. One of the primary challenges is the complexity of the disease itself, characterized by its aggressive nature and the development of resistance to existing therapies. Despite the remarkable progress in targeted therapies like HER2 inhibitors, the emergence of resistance mechanisms poses a significant hurdle. Additionally, the high cost of innovative treatments and the economic burden on healthcare systems may limit accessibility for patients, impacting the widespread adoption of breakthrough therapies and hindering the market size. Furthermore, the limited availability of comprehensive molecular profiling and diagnostic tools could impede personalized treatment strategies, hampering the ability to tailor therapies to individual patients.

Metastatic HER2-Positive Breast Cancer Market Report Metrics	Details
Study Period	2019–2032
Coverage	7MM [the United States, the EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan].
Metastatic HER2-Positive Breast Cancer Market Size in 2022	USD 2.6 Billion
Key Metastatic HER2-Positive Breast Cancer Companies	Byondis, Roche, Ambrx, Zymeworks, Jazz Pharmaceuticals, Pfizer, and others
Key Pipeline Metastatic HER2-Positive Breast Cancer Therapies	SYD985 (trastuzumab duocarmazine), Giredestrant, ARX788, Zanidatamab, IBRANCE (palbociclib), and others

Scope of the Metastatic HER2-Positive Breast Cancer Market Report

Metastatic HER2-Positive Breast Cancer Therapeutic Assessment: Metastatic HER2-Positive Breast Cancer current marketed and emerging therapies
Metastatic HER2-Positive Breast Cancer Market Dynamics: Key Market Forecast Assumptions of Emerging Metastatic HER2-Positive Breast Cancer Drugs and Market Outlook
Competitive Intelligence Analysis: SWOT analysis and Market entry strategies
Unmet Needs, KOL's views, Analyst's views, Metastatic HER2-Positive Breast Cancer Market Access and Reimbursement

Discover more about metastatic HER2-positive breast cancer drugs in development @ Metastatic HER2-Positive Breast Cancer Clinical Trials

Table of Contents

1.	Metastatic HER2-Positive Breast Cancer Key Insights
2.	Metastatic HER2-Positive Breast Cancer Report Introduction
3.	Metastatic HER2-Positive Breast Cancer Overview at a Glance
4.	Metastatic HER2-Positive Breast Cancer Executive Summary
5	Metastatic HER2-Positive Breast Cancer Key Events
6	Epidemiology and Market Forecast Methodology
6.	Disease Background and Overview
7.	Metastatic HER2-Positive Breast Cancer Treatment and Management
8.	Metastatic HER2-Positive Breast Cancer Guidelines
9.	Metastatic HER2-Positive Breast Cancer Epidemiology and Patient Population
10.	Patient Journey
11.	Key Endpoints in Metastatic HER2-Positive Breast Cancer
12.	Metastatic HER2-Positive Breast Cancer Marketed Drugs
13.	Metastatic HER2-Positive Breast Cancer Emerging Drugs
14.	7MM Metastatic HER2-Positive Breast Cancer Market Analysis
15.	Market Access and Reimbursement
16.	KOL Views
17.	Unmet Needs
18.	SWOT Analysis
19.	Appendix
20.	DelveInsight Capabilities
21.	Disclaimer
22.	About DelveInsight

Metastatic HER2-Positive Breast Cancer Epidemiology Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, and metastatic HER2-positive breast cancer epidemiology trends.

Metastatic HER2-Positive Breast Cancer Pipeline

Metastatic HER2-Positive Breast Cancer Pipeline Insight – 2023 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key metastatic HER2-positive breast cancer companies, including Byondis, Roche, Ambrx, Zymeworks, Jazz Pharmaceuticals, Pfizer, among others.

Breast Cancer Market

Breast Cancer Market Insights, Epidemiology, and Market Forecast – 2032 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key breast cancer companies including Veru, Sanofi, Roche, AstraZeneca, Eli Lilly, EQRx, Gilead, Sermonix Pharmaceuticals, Evgen Pharma, Tyme, Genentech, Daiichi Sankyo, among others.

Metastatic Breast Cancer Pipeline

Metastatic Breast Cancer Pipeline Insight – 2023 report provides comprehensive insights about the pipeline landscape, including clinical and non-clinical stage products, and the key metastatic breast cancer companies, including Roche, RemeGen, SynCore Biotechnology, Allarity Therapeutics, Daiichi Sankyo Company, Jiangsu Alphamab Biopharmaceuticals Co., Ltd, Byondis B.V., Jiangsu Hansoh Pharmaceutical Co., Ltd., Shanghai Miracogen Inc., Ambrx, Inc., Daehwa Pharmaceutical Co., Ltd., Phoenix Molecular Designs, GlycoMimetics Incorporated, Rhizen Pharmaceuticals SA, Menarini Group, Samus Therapeutics, Inc., Hanmi Pharmaceutical Company Limited, Jiangxi Qingfeng Pharmaceutical Co. Ltd., Immutep Limited, Arvinas Inc., G1 Therapeutics, Mirati Therapeutics Inc., Chia Tai Tianqing Pharmaceutical, Shanghai Pharmaceuticals Holding Co., Ltd, Pfizer, OncoTherapy Science, Inc., Eisai Inc., Dizal Pharmaceuticals, Jiangsu Hengrui Medicine Co., Tyme, Inc, Orion Pharma, HiberCell, Inc., Rhizen Pharmaceuticals SA, Hutchison Medipharma Limited, OncoPep Inc., Taizhou Hanzhong biomedical co. LTD, among others.

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SOURCE DelveInsight Business Research, LLP