Makucell™ Launches Renewnt™, a Revolutionary Skin Care Line at the 70th Annual Meeting of the American Academy of Dermatology

SCOTTSDALE, Ariz. and LOS ANGELES, March 15, 2012 /PRNewswire-USNewswire/ -- Makucell, Inc., a life science company dedicated to the development, manufacture and distribution of non-prescriptive topical products formulated to address the challenges of aging skin launches Renewnt™ , (pronounced "Re-new-int"), a revolutionary new skin care line using unique science and a novel approach to cellular aging. Not a retinoid, nor a botanical, not a growth media protein, biologic, or antioxidant, the Renewnt™ brand proprietary molecule, Asymmtate™, is an original technology platform never before offered in the cosmeceutical market. Renewnt™, Makucell's innovative, science-driven portfolio of non-prescription products, was developed by leading laboratory researchers and dermatologists and clinically tested. Each product targets a specific area of the body with all Renewnt™ formulations reducing the appearance of fine lines, wrinkles, roughness, thinning skin and pigment irregularities.

Stem Cells and Skin Aging
In order to function properly, skin cells must continuously replace themselves. These replacement skin cells arise from skin stem cells. The number of stem cells remains relatively constant throughout our life. However, as we age, stem cell divisions become sluggish and occur less frequently, slowing the activities that make skin youthful looking.

The Science Behind Makucell's New Approach
The decision of the skin stem cells to remain dormant, divide or differentiate (become normal, active tissue cells) is critical, and determined by the body's signal pathways. Multiple paths funnel into a common signaling pathway called "Wnt" (pronounced "wint"). Asymmtate™, is a selective modulator of the Wnt signaling pathway and encourages optimal signaling. Optimal signaling stimulates the skin stem cells to begin the process leading to keratinocytes, fibroblasts and other dermal cells, which produce collagen, elastic tissue, and other substances in the supporting skin matrix. The end result is skin that is tighter, more luminous and younger-looking. This essential regenerative process is the key differentiator in Makucell's Renewnt™ skin care products.

Dr. Lawrence Rheins, President and Chief Executive Officer of Makucell notes, "We met our goal — to create a simple, easy-to-use product line that produces visible results without a prescription or an exorbitant price tag.  Renewnt™ is currently offered exclusively through aesthetic skincare professionals." Dr. Rheins continues, "Truth and transparency guide Makucell's corporate conduct and product claims. Our information and research will be available to anyone who wants to read it."  

"The launch of Renewnt™ is the culmination of many years of laboratory research by a gifted team at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at the University of Southern California, Keck School of Medicine, along with the tremendous commitment and initiative of the Makucell senior managers," adds Dr. Michael Kahn, Makucell co-founder and Board Chairman, and the distinguished researcher who led the Broad Center team which developed the technology. "We believe that our proprietary molecule, Asymmtate™, is a real breakthrough — a research advance transferred to a technology platform used in skin care designed to combat the visible signs of aging. As the skin's texture and strength improves, it has a rejuvenated, more youthful appearance."

Michael Casanova, Makucell Vice President of Sales comments, "Renewnt™ products are new cosmetic agents. Unlike most products in the market today, Asymmtate™ penetrates into and through the epidermis and the dermis, yet remains active." He concludes, "The Makucell team is proud to introduce the revolutionary Renewnt™ products at the 70th Annual Meeting of the American Academy of Dermatology. We invite participants to visit us at booth 314 to learn more about our technology and products. Orders taken at the AAD meeting are pre-sale and will be delivered mid-April."

Makucell's current Renewnt™ skin care product line includes:

Renewnt™ for Firmness, a neck and décolletage cream designed to hydrate and improve elasticity to improve roughness, reduce wrinkles and firm this delicate skin.

Renewnt™ for Hydration, a day and night facial cream that is specifically formulated for the face to restore a stronger, nourished, moisturized and more youthful appearance.

Renewnt™ for Strength, formulated for the dry, thinning skin of the hands and forearms. It soothes and seals in moisture to help repair the signs of aging and restore the essential skin barrier.

Renewnt™ for Brightness, a brightening serum formulated to address areas of irregular skin pigmentation to rejuvenate, brighten and produce a more even skin tone.

Makucell
Makucell Inc. (www.Makucell.com) is a life science company dedicated to the development, manufacture and distribution of non-prescriptive topical products formulated to address the challenges of aging and photo-damaged skin.  Based on scientific research at the Eli & Edythe Broad Center for Regenerative Medicine and Stem Cell Research at the University of Southern California, Keck School of Medicine, Makucell's products are formulated to enhance the skin's appearance, making it stronger and more youthful-looking. The company's new proprietary technology, Asymmtate™, works with an individual's own skin stem cells to maintain cellular differentiation as we age. Makucell has a full portfolio of products in its pipeline directed toward improving the appearance of skin, hair and nails which uses the Asymmtate™ core technology platform. For media and investment inquiries, please contact Lawrence Rheins, President and CEO at lrheins@makucellinc.com or 1-855-MAKUCELL.

USC Stevens Institute for Innovation
The USC Stevens Institute for Innovation (http://stevens.usc.edu) is a university-wide resource in the Office of the Provost at the University of Southern California that helps identify, nurture, protect, and transfer to the market the most exciting innovations from USC. It also provides a central connection for industry seeking cutting-edge innovations in which to invest. As part of this role, the USC Stevens Institute manages the university's intellectual property portfolio stemming from its $650M annual research program. Furthermore, the USC Stevens Institute develops the innovator as well as innovations, through educational programs, community-building events, and showcase opportunities.

Media Contact
Lawrence A. Rheins, President & CEO
[email protected]
1-855-MAKUCELL

SOURCE USC Stevens Institute for Innovation

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