Kenneth Rainin Foundation Awards Over $3 Million to High-Risk, High Reward Inflammatory Bowel Disease Research Projects

"Our focus as a funder is to provide support at the early stages of research, before new ideas have been proven, when researchers need it most," said Dr. Jennifer Rainin, CEO of the Kenneth Rainin Foundation. "Challenging investigators to push boundaries gives us the best chance of achieving breakthroughs in IBD research."

The Foundation's grants are awarded to early-career and seasoned investigators pursuing a range of projects that could potentially lead to transformative discoveries about IBD. Select grants fund research that incorporates bioengineering or new technology, such as Dr. Christopher Contag's research on using Raman-based microendoscopy to detect dysplasia in patients with ulcerative colitis, and Dr. Hyun Jung Kim's development of "Crohn's Disease-on-a-Chip" model to measure the effect of fecal microbiota transplant prior to the clinical procedure.

"Our funding strategy encourages tangible and measurable outcomes," said Dr. Averil Ma, chair of the Rainin Foundation's Scientific Advisory Board and Chief of Gastroenterology at the University of California, San Francisco. "We are excited about advancing the understanding of IBD and how this research will lead to translational work that links the science to the patient."

The Foundation's grants will support projects in the areas of novel therapeutics, the microbiome, immunity and inflammation, and genetics and other risk factors in IBD, as well as diet and nutrition-related research through its Innovator Awards, which fund proof of concept research projects. 

"This Innovator Award is coming at the perfect time for my lab and will serve as a catalyst for new approaches in investigating the microbiota and immune system," said Ken Cadwell, PhD, Associate Professor, Department of Microbiology, New York University.

The 2016 Innovator Awards include:

• Milena Bogunovic, MD, PhD, Pennsylvania State University
• Ken Cadwell, PhD, New York University
• John Chang, MD, University of California, San Diego
• Jean-Frédéric Colombel, MD, Icahn School of Medicine at Mount Sinai
• Christopher Contag, PhD, Stanford University
• Jun Huh, PhD, University of Massachusetts
• Nobuhiko Kamada, PhD, University of Michigan
• Hyun Jung Kim, PhD, University of Texas at Austin
• Eric Martens, PhD, University of Michigan
• Corinne Maurice, PhD, McGill University
• Inga Peter, PhD, Icahn School of Medicine at Mount Sinai 

The Foundation's Breakthrough Awards provide continued funding to Innovator Award grantees who have demonstrated significant progress in advancing their original research goals.

"Our project is a testimony of the Foundation's goals to cultivate innovative ideas and fund risky projects that have the potential to change the way we diagnose and treat IBD," said Mohamed Abou Donia, PhD, Assistant Professor, Department of Molecular Biology, Princeton University. "We are excited about the additional year of support, which will allow us to capitalize on our initial findings, and further explore microbiome-derived small molecules as potential new diagnostic and therapeutic tools for IBD."

The 2016 Breakthrough Award recipients are:  

• Michel Bagnat, PhD, Duke University
• Gregory Barton, PhD, University of California, Berkeley
• Marco Colonna, MD, Washington University
• Mohamed Abou Donia, PhD, Princeton University
• Gerard Eberl, PhD, Institut Pasteur
• Katherine Fitzgerald, PhD, University of Massachusetts
• Iliyan Iliev, PhD, Weill Cornell Medical College
• Kate Jeffrey, PhD, Massachusetts General Hospital Research Institute 
• Jeffrey Karp, PhD, Brigham and Women's Hospital 
• Dan Littman, MD, PhD, New York University
• Timothy Lu, MD, PhD, Massachusetts Institute of Technology
• Richard Maizels, PhD, University of Glasgow
• Daniel Mucida, PhD, The Rockefeller University
• Gabriel Rabinovich, PhD, and Karina V. Mariño, PhD, Fundacion Instituto de Biologia y Medicina Experimental
• David Suskind, MD, Seattle Children's Hospital
• Kevin Whelan, PhD, King's College London

"The Rainin Foundation is focused on solving IBD by corralling world-class scientists from diverse disciplines. This distinct approach not only fosters unique perspectives, but it urges cutting edge science to come together for a common goal," said Kate Jeffrey, PhD, Assistant Professor, Department of Medicine, Harvard Medical School. "Obtaining the Foundation's funding was the sole impetus for my lab to be able to embark on this novel project. There are very few funding avenues in the science world that support innovation and bold ideas so whole-heartedly as the Rainin Foundation."

Complementing its grant programs, the Foundation will host its sixth annual Innovations Symposium on July 24–25, 2017, in San Francisco. This event brings together scientific leaders, trainees, researchers and clinicians from around the world to collaborate and learn together to move IBD research forward. Read more about the Symposium at:  krfoundation.org/symposium.

About the Kenneth Rainin Foundation

Kenneth Rainin Foundation is a family foundation that collaborates with creative thinkers in the Arts, Education and Health. At the Rainin Foundation, we believe in taking smart risks to achieve breakthroughs. We support visionary artists in the Bay Area, create opportunities for Oakland's youngest learners, and fund researchers on the forefront of scientific discoveries. Since 2010, the Foundation has awarded99 grants and over $11 million in funding for promising scientific research projects with the potential to cure Inflammatory Bowel Disease. The Foundation's Scientific Advisory Board, comprised of leading scientists throughout the U.S. and abroad, guides the Foundation's Health grants program. More at krfoundation.org.

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SOURCE The Kenneth Rainin Foundation

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