How to Find the Optimal Mobilisation Strategy for Haematopietic Stem Cells - Impact, Challenges and Solutions

LONDON, December 15, 2016 /PRNewswire/ --

Patrick Wuchter, Kai Hübel, European Oncology & Haematology, 2016;12(2):87-92, https://doi.org/10.17925/EOH.2016.12.02.87

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Published recently in European Oncology & Haematology Review, the peer-reviewed journal from touchONCOLOGY, Patrick Wuchter and Kai Hubel discuss mobilisation strategies for haematopietic stem cells. Autologous haematopoietic stem-cell transplantation (HSCT) is the standard treatment for a number of haematological malignancies. Achieving sufficient haematopoietic stem cell mobilisation is a prerequisite, but exactly how to define and achieve this goal remains a subject of debate. Key questions include which pharmacological agents to use, timing of treatments and mobilisation, and, in particular, target numbers of stem cells. Clinicians from Europe, North America and Asia compared their experiences and discussed these issues at a satellite workshop during the 3rd International Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM 2015). This review discusses the challenges of optimising leukapheresis in the context of these discussions.

The full peer-reviewed, open-access article is available here:

https://doi.org/10.17925/EOH.2016.12.02.87

Disclosure: Patrick Wuchter is an Advisory Board member and has received honoraria from Sanofi-Aventis. He is an Advisory Board member and has received travel grants from Hexal AG. Kai Hubel is an Advisory Board member and received honoraria from Sanofi-Aventis, Roche, Gilead, Teva, Hexal, Celgene and Amgen.

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