NEW YORK, Jan. 29, 2015 /PRNewswire/ -- This report analyzes the worldwide markets for Organ and Tissue Transplantation in Number of Procedures. The global and regional markets (except the US) for 'Organ and Tissue Transplantation' in this report are analyzed by the following Product Segments - Organ Tranplantation (Heart, Kidneys, Liver, Pancreas, and Lungs). The US market for 'Organ and Tissue Transplantation' in this report is analyzed by the following Product Segments: Organ Type (Heart, Kidneys, Liver, Pancreas, Lungs, and Intestine), Tissue Type (Cornea, Heart Valve, Skin Grafts, Vascular Grafts, Bone Marrow, and Bone Grafts), and Bone Graft Transplantation (By Graft Type: Autologous Graft, Allograft, and Other Materials; By Application Type: General Orthopedics, Spinal Fusions, and Cranio/Maxillofacial). The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of World. Annual estimates and forecasts are provided for the period 2013 through 2020. Also, a seven-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 24 companies including many key and niche players such as -
CryoLife, Inc.Exactech, Inc.Folio BiosciencesKöhler ChemieLifeCell Corporation
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I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONSStudy Reliability and Reporting Limitations I-1Disclaimers I-2Data Interpretation & Reporting Level I-2Quantitative Techniques & Analytics I-3Product Definition and Scope of Study I-3Product Definitions I-4Organ Transplantation I-4Heart Transplantation I-4Kidney Transplantation I-4Liver Transplantation I-4Pancreas Transplantation I-5Small Intestine Transplantation I-5Lungs I-5Tissue Transplantation I-5Corneal Transplantation I-5Blood Stem Cell Transplantation I-5Bone Marrow Transplantation I-6Heart Valves Transplantation I-6II. EXECUTIVE SUMMARY
1. MARKET OVERVIEW II-1
A Quick Primer II-1
Europe and the United States Lead the Global Organ Transplants
Market II-1
Table 1: Global Organ Transplants by Leading Country in Terms
of No. of Transplants Per Million Population (PMP) for the
Year 2012 (includes corresponding Graph/Chart) II-2
Kidney and Liver Transplants Top the Organ Transplants Worldwide II-2
Table 2: Global Kidney Transplants from Deceased Donor by
Select Countries (2013): No. of Transplants Per Million
Population (PMP) by Country (includes corresponding
Graph/Chart) II-3
Table 3: Global Kidney Transplants from Living Donor bySelect Countries (2013): No. of Transplants per MillionPopulation (PMP) by Country (includes correspondingGraph/Chart) II-3
Table 4: Global Liver Transplants from Deceased Donor by
Select Countries (2013): No. of Transplants per Million
Population (PMP) by Country (includes corresponding
Graph/Chart) II-4
Table 5: Global Liver Transplants from Living Donor by SelectCountries (2013): No. of Transplants per million population(PMP) by Country (includes corresponding Graph/Chart) II-4
Table 6: Global Heart Transplants by Select Countries (2013):
No. of Transplants Per million population (includes
corresponding Graph/Chart) II-5
Table 7: Global Lung Transplants by Select Countries (2013):Number of Transplants Per Million Population (includescorresponding Graph/Chart) II-5
Table 8: Global Pancreas Transplants by Select Countries
(2013): Number of Transplants Per Million Population
(includes corresponding Graph/Chart) II-6
Demand and Supply Imbalance II-6
Table 9: European Organ Transplantation Waiting Lists: No. of
Waiting Patients by Organ Type (2012) (includes corresponding
Graph/Chart) II-6
Table 10: US Waiting List of Patients for Organ Transplantsby Organ Type: As of August 2014 (includes correspondingGraph/Chart) II-7Measures to Address Organ Shortage II-7Cardiac Arrest Death Patients: The Untapped Potential Donors II-8Table 11: Leading Countries in Terms of Number of Donorsafter Cardiac Death (DCD) in 2013 (includes correspondingGraph/Chart) II-8Donation after Circulatory Death - Rife with Ethical Issues II-8Living Donor Organs on the Rise II-9Table 12: Global Living Organ Donors by Leading Country inTerms of No. of Donors Per Million Population (PMP) for theYear 2013 (includes corresponding Graph/Chart) II-9
Table 13: Global Deceased Organ Donors by Leading Country in
Terms of No. of Donors Per Million Population (PMP) for the
Year 2013 (includes corresponding Graph/Chart) II-10
Transplantation - Expenditure and Regional Variations II-10
Table 14: US Organ Transplantation Charges - Total Billed
Charges per Transplant by Type (2011) (includes
corresponding Graph/Chart) II-11
Bone Grafts: An Overview II-12
Table 15: Fractures by Age Group (2012): Percentage Share
Breakdown of Number of Fractures by Age Group (includes
corresponding Graph/Chart) II-13
Table 16: Global Orthopedic Market by Segment (2013E):Percentage Breakdown of Value Sales for Spine, Trauma, Knees,Hips, Orthobiologics, Extremities and Others (includescorresponding Graph/Chart) II-13Key Statistics in Global Orthopedics Industry II-14Table 17: Worldwide Orthopedic Market (2013E): PercentageMarket Share Breakdown of Value Sales by Company for DePuySynthes, Stryker, Zimmer, Smith & Nephew, Medtronic, andOthers (includes corresponding Graph/Chart) II-14
Table 18: Worldwide Market for Orthopedic Implants in Spinal
Procedures (2013E): Percentage Market Share Breakdown of
Value Sales by Company for Medtronic, J&J and Others
(includes corresponding Graph/Chart) II-14
Table 19: Worldwide Market for Orthopedic Implants forReconstructive Procedures (2013E): Percentage Market ShareBreakdown of Value Sales by Company for Zimmer, J&J,Stryker, Biomet, Smith & Nephew, and Others (includescorresponding Graph/Chart) II-14
Table 20: Worldwide Market for Orthopedic Implants for
Trauma Procedures (2013E): Percentage Market Share Breakdown
of Value Sales by Company for J&J, Stryker, Biomet Smith &
Nephew, Zimmer, and Others (includes corresponding
Graph/Chart) II-15
Table 21: Global Joint Replacement Market (2013E):Percentage Market Share Breakdown of Sales for Zimmer, DePuySynthes, Stryker, Biomet, Smith & Nephew, and Others(includes corresponding Graph/Chart) II-15Orthopedic Grafts - Regional Market Variations II-15
2. MARKET TRENDS II-16
Combined Organ Transplantation - Gaining Attention II-16
Table 22: Multiple Organ Transplants in the US - No. of
Transplants by Type (2010-2014) II-16
Illegal Organ Trafficking - A Risky Proposition II-16
Increasing Consent Rates - A Key Factor II-17
Transplant Tourism - Creating Brighter Avenues II-17
Alliances to Play a Key Role II-17
Graying Population and Chronic Diseases Surge Need for
Transplants II-17
Table 23: Aged Population (65+ Years) as a Percentage of the
Total Population: 2000 Vis-a-vis 2025 (includes corresponding
Graph/Chart) II-18
Table 24: Aged Population (65+ Years) as a Percentage of theTotal Population by Region: 2000 Vis-a-vis 2025 (includescorresponding Graph/Chart) II-19
Table 25: Global Aging Population by Age Group: 1975-2050
(includes corresponding Graph/Chart) II-20
Table 26: Aging Population by Age Group in More DevelopedCountries: 1975-2050 (includes corresponding Graph/Chart) II-21
Table 27: Aging Population by Age Group in Less Developed
Countries: 1975-2050 (includes corresponding Graph/Chart) II-22
Table 28: Aging Population by Age Group in Least DevelopedCountries: 1975-2050 (includes corresponding Graph/Chart) II-23Rising Incidences of Degenerative Intervertebral Disc DiseasesPromote Tissue Transplantation II-23Table 29: % of Women Affected by Osteoporosis (includescorresponding Graph/Chart) II-24Fetal Tissue for Bionic Devices - Assuming Importance II-24LVADs - Gaining Significance for Impending Heart Transplants II-24Stem Cell Based Bone Grafts - Fastest Growing Bone GraftSubstitute Segment II-25Synthetic Bone Graft - The Latest Trend II-25Stem Cell Therapies - Expanding the Horizon of Transplantation II-26Rising Cancer Incidence to Drive Stem Cell Transplants II-26Table 30: Number of New Cancer Cases Worldwide by AffectedSite: 2012 (in Thousands) (includes correspondingGraph/Chart) II-27Demineralized Bone Matrix (DBM): Strong Growth but ToughCompetition II-27Bone Morphogenetic Protein - Safety Concerns Affect GrowthProspects II-28Dental Bone Grafting - A High Potential Market II-28Table 31: Global Dental Regeneration Market (2013E):Percentage Share Breakdown of Value Sales for BoneAllografts, Membranes, Tissue Regeneration (includescorresponding Graph/Chart) II-29
3. TECHNOLOGICAL INNOVATIONS II-30
3-D Bioprinting II-30
Preloaded Corneal Tissue Cartridges II-30
Lung Perfusion Technology II-30
4. MAJOR ISSUES IMPACTING TRANSPLANTATION MARKET II-31Organ Rejection - A Major Barrier to Transplantation II-31Scarcity of Donor Organs - A Stumbling Block in OrganTransplantation II-31Other Issues for Organ Transplantation II-31Ethical Concerns in Transplants II-31Bioethical Issues Hinder Organ Donation Process II-32Lack of Requisite Expertise - Hindering Implantation Process II-32Corneal Transplantation in Developing Countries: Key Challenges II-32
5. PRODUCT OVERVIEW II-33
Organ and Tissue Transplantation II-33
Organ Transplantation II-33
Heart Transplantation II-33
Heart Diseases and Disorders II-34
Post-Operative Complications and Consequences of Heart
Transplants II-34
Bleeding II-34
Infection II-34
Arrythymia II-34
Heart Attack II-34
Coronary Artery Disease II-35
Respiratory Dysfunction II-35
Renal Dysfunction II-35
Graft Rejection and Dysfunction II-35
Death II-35
Kidney Transplantation II-35
Kidney Disorders and Diseases II-36
Donor Evaluation II-36
Waiting List II-36
Surgery/Post-Operation II-36
Post-Operative Supervision and Issues II-36
Liver Transplantation II-37
Liver Disorders and Diseases II-38
Pancreas Transplantation II-38
Post-Operative Complications and Consequences of Pancreas
Transplants II-39
Small Intestine Transplantation II-39
Intestine Disorders and Diseases II-39
Heart-and-Lung Transplantation II-39
Lung Transplantation II-40
Lung Diseases and Disorders II-40
Lung Patients Survival Statistics II-40
Tissue Transplantation II-40
Types of Grafts II-40
Autograft II-40
Allograft / Homograft II-41
Transplant Tolerance II-41
Isograft II-41
Xenograft II-42
Corneal Transplantation II-42
Penetrating Keratoplasty II-43
Lamellar (Non-Penetrating) Keratoplasty II-43
Aftercare II-43
Risks Associated with Corneal Transplants II-43
Transplantation Outcomes II-43
Morbidity and Mortality Rates II-44
Alternatives II-44
Blood Stem Cells II-44
Peripheral Blood Stem Cell Transplant II-44
Umbilical Cord Blood Stem Cell Transplant II-44
Bone Marrow and Hematopoietic Stem Cells II-44
Bone and Tissue Transplantation II-45
Bone Marrow Transplants II-45
Stem Cell Therapy II-45
Human Heart Valves II-46
Atrioventricular Valves II-46
Mitral Valve II-46
Tricuspid Valve II-46
Semilunar Valves II-47
Aortic Valve II-47
Pulmonic Valve II-47
Pathology of Valves II-47
Prosthetic Heart Valves II-47
Prosthetic Mechanical Valve II-48
Advantages II-48
Disadvantages II-48
Prosthetic Biologic Valve II-48
Advantages II-49
Disadvantages II-49
Fetal Cells II-49
Fetal Tissue for Transplantation II-50
Storage Duration Time II-50
Storage Time Period for Organs and Tissues II-50
Cold Ischemia Time II-50
Transplantation Immunology II-50
Acute Cellular Rejection II-50
Chronic Rejection II-51
Post Transplant Observations II-51
Types of Donors II-51
Alive Donors II-51
Related Donors II-52
Good Samaritans II-52
Rewarded/Forced Donors II-52
Deceased Donors II-52
Directed / Allocated II-52
Organs and Tissues Transplanted by Type of Donor II-52
Organ/Tissue Donation and Eligibility Criteria II-53
Factors Considered for Matching Recipients to Donor Organs II-53
Testing II-54
Blood Typing II-54
Tissue Typing II-54
Histocompatibility - A Major Barrier for Organ Transplantation II-54
Transplantation - Safety Requirements II-55
Waiting List II-55
Active Waiting List Patients II-56
Inactive Waiting List Patients II-56
History II-56
6. ARTIFICIAL ORGANS - AN ALTERNATIVE TO SOLID ORGAN TRANSPLANTS II-59Artificial Organs Revolutionize Medical Technology Industry II-59Artificial Organs II-59Categorization of Artificial Organs II-59External Artificial Organs II-59Internal or Implantable Artificial Devices II-60Artificial Heart II-60Total Artificial Heart (TAH) II-60Ventricle Assist Device (VAD) II-60Right Ventricular Assist Systems (RVAS) II-60Left Ventricular Assist Systems (LVAS) II-60Various Ventricle Assist Devices Approved in the Recent Past II-61Artificial Kidney (Dialyzer) II-61Limitations of Artificial Kidney II-62Artificial Liver II-62Various Liver Assist Devices II-62Categorization of Liver Devices II-62Mechanical Systems II-62Bio-Artificial Systems II-63Artificial Pancreas II-63Artificial Lungs (Oxygenator) II-63Types of Artificial Lung II-63Artificial Cornea II-63Keratoprostheses II-64Tissue Engineered Corneas II-64Artificial Skin/Skin Replacement Products II-64AlloDerm Regenerative Tissue Matrix II-64Apligraf II-64Cymetra Micronized AlloDerm Tissue II-64Dermagraft II-64Epicel II-65Integra Products II-65OrCel II-65TransCyte II-65Core Competitive Factors II-65Market Outlook for Artificial Organs II-66
7. PRESERVATION SOLUTIONS & IMMUNOSUPPRESSANT DRUGS II-67
Organ Preservation Solutions II-67
Celsior Solution II-67
Collins Solution II-67
Euro Collins Solution II-67
Custodiol® HTK Solution II-67
Hypothermosol II-67
ViaSpan II-68
Immunosuppressant Drugs II-68
Antibody Products for Treatment of Organ Transplant Rejection II-68
Antithymocyte Globulin II-68
ATGAM II-68
Thymoglobulin II-69
Therapeutic Antibody Products II-69
Antiproliferative Agents II-69
Azathioprine II-69
CellCept II-69
Certican II-69
Myfortic II-69
Calcineurin Inhibitors II-69
Cyclosporine II-70
Gengraf II-70
Neoral II-70
Prograf (Tacrolimus) II-70
TOR Inhibitors II-70
Side Effects of Immunosuppression Therapy II-70
Select Players Engaged in Immunosuppressant Drugs/Anti-
Rejection Therapy/ Bridge-to- Transplantation Devices II-71
Astellas Pharma US, Inc. (USA) II-71
F.Hoffmann-La Roche Ltd. (Switzerland) II-71
Novartis AG (Switzerland) II-71
Wyeth (USA) II-72
Abiomed, Inc. (USA) II-72
Fresenius Medical Care AG & Co. KGaA (Germany) II-72
Gambro AB (Sweden) II-73
Genzyme Corporation (US) II-73
Jarvik Heart, Inc. (US) II-74
ReliantHeart (US) II-74
SynCardia Systems (US) II-74
Terumo Corporation (Japan) II-74
Teleflex Inc. (US) II-75
Thoratec Corporation (US) II-76
Heart Ware International, Inc. (US) II-76
8. REGULATORY ENVIRONMENT II-77Transplant Center II-77Organ Procurement Organization (OPO) II-77Health Resources and Services Administration (HRSA) II-77Division of Transplantation (DoT) II-77United Network for Organ Sharing (UNOS) II-77Organ Procurement and Transplantation Network (OPTN) II-77University Renal Research and Education Association (URREA) II-78Scientific Registry of Transplant Recipients (SRTR) II-78Funding Sources II-78Patient Education and Advocacy Organizations II-78Legal Framework for Transplantation II-79Legislation Covering Organ Transplant II-79Organ Transplantation and Ethics II-79
9. PRODUCT DEVELOPMENT/INNOVATIONS II-81
AlloSource Introduces AlloMend™ II-81
Synergy Biomedical Launches Bonegraft Product BioSphere Putty II-81
K2M Launches Venado Bonegraft Systems II-81
OTS Launches LifeCradle® Heart Perfusion System II-81
BioHorizons Launches MinerOss® Cancellous Dental Grafts II-81
K2M Launches Vesuvius Graft Systems II-81
OTTR Launches Pediatric BMT System II-82
Amedica to Begin Distribution of Dynamic Bone II-82
BioMimetic Introduces Augmatix Bonegraft II-82
Integra Introduces Integra® Allograft Wedge System II-82
10. RECENT INDUSTRY ACTIVITY II-83ThermoGenesis and TotipotentRX Complete 20th Pediatric BMT II-83LifeCell Acquires Adipose Tissue Injector from Tau Tona Group II-83FBiH Signs Agreement with Croatia II-83AlloSource and HumaCyte Enter Manufacturing Agreement II-83PSF Partners with MTF for Research Grants II-83Wright Medical Partners with BioMimetic Therapeutics II-83Pharmalink Signs Manufacturing Agreement with GP Pharm II-84Isotechnika Pharma Ends Agreement with ILJIN II-84Veloxis Starts STRATO Study in Kidney-Transplant Recipients II-84Isotechnika Signs Voclosporin License Agreement with Vifor Pharma II-84
11. FOCUS ON SELECT GLOBAL PLAYERS II-85
CryoLife, Inc.(US) II-85
Exactech, Inc. (US) II-85
Folio Biosciences (US) II-86
Köhler Chemie (Germany) II-86
LifeCell Corporation (US) II-86
Medtronic, Inc. (US) II-87
Organogenesis, Inc. (US) II-87
Organ Recovery Systems (US) II-87
Organ Transport Systems (US) II-88
XVIVO Perfusion AB (Sweden) II-88
12. GLOBAL MARKET PERSPECTIVE II-89Table 32: World Recent Past, Current & Future Analysis forOrgan Transplantation by Geographic Region - US, Canada,Europe, Asia-Pacific (including Japan), Latin America and Restof World Markets Independently Analyzed by Number ofProcedures for Years 2013 through 2020 (includes correspondingGraph/Chart) II-89
Table 33: World Historic Review for Organ Transplantation by
Geographic Region - US, Canada, Europe, Asia-Pacific
(including Japan), Latin America and Rest of World Markets
Independently Analyzed by Number of Procedures for Years 2006
through 2012 (includes corresponding Graph/Chart) II-90
Table 34: World 15-Year Perspective for Organ Transplantationby Geographic Region - Percentage Breakdown of Number ofProcedures for US, Canada, Europe, Asia-Pacific (includingJapan), Latin America and Rest of World Markets for Years2006, 2014 & 2020 (includes corresponding Graph/Chart) II-91
Table 35: World Recent Past, Current & Future Analysis for
Heart Transplantation by Geographic Region - US, Canada,
Europe, Asia-Pacific (including Japan), Latin America and Rest
of World Markets Independently Analyzed by Number of
Procedures for Years 2013 through 2020 (includes corresponding
Graph/Chart) II-92
Table 36: World Historic Review for Heart Transplantation byGeographic Region - US, Canada, Europe, Asia-Pacific(including Japan), Latin America and Rest of World MarketsIndependently Analyzed by Number of Procedures for Years 2006through 2012 (includes corresponding Graph/Chart) II-93
Table 37: World 15-Year Perspective for Heart Transplantation
by Geographic Region - Percentage Breakdown of Number of
Procedures for US, Canada, Europe, Asia-Pacific (including
Japan), Latin America and Rest of World Markets for Years
2006, 2014 & 2020 (includes corresponding Graph/Chart) II-94
Table 38: World Recent Past, Current & Future Analysis forKidney Transplantation by Geographic Region - US, Canada,Europe, Asia-Pacific (including Japan), Latin America and Restof World Markets Independently Analyzed by Number ofProcedures for Years 2013 through 2020 (includes correspondingGraph/Chart) II-95
Table 39: World Historic Review for Kidney Transplantation by
Geographic Region - US, Canada, Europe, Asia-Pacific
(including Japan), Latin America and Rest of World Markets
Independently Analyzed by Number of Procedures for Years 2006
through 2012 (includes corresponding Graph/Chart) II-96
Table 40: World 15-Year Perspective for Kidney Transplantationby Geographic Region - Percentage Breakdown of Number ofProcedures for US, Canada, Europe, Asia-Pacific (includingJapan), Latin America and Rest of World Markets for Years2006, 2014 & 2020 (includes corresponding Graph/Chart) II-97
Table 41: World Recent Past, Current & Future Analysis for
Liver Transplantation by Geographic Region - US, Canada,
Europe, Asia-Pacific (including Japan), Latin America and Rest
of World Markets Independently Analyzed by Number of
Procedures for Years 2013 through 2020 (includes corresponding
Graph/Chart) II-98
Table 42: World Historic Review for Liver Transplantation byGeographic Region - US, Canada, Europe, Asia-Pacific(including Japan), Latin America and Rest of World MarketsIndependently Analyzed by Number of Procedures for Years 2006through 2012 (includes corresponding Graph/Chart) II-99
Table 43: World 15-Year Perspective for Liver Transplantation
by Geographic Region - Percentage Breakdown of Number of
Procedures for US, Canada, Europe, Asia-Pacific (including
Japan), Latin America and Rest of World Markets for Years
2006, 2014 & 2020 (includes corresponding Graph/Chart) II-100
Table 44: World Recent Past, Current & Future Analysis forPancreas Transplantation by Geographic Region - US, Canada,Europe, Asia-Pacific (including Japan), Latin America and Restof World Markets Independently Analyzed by Number ofProcedures for Years 2013 through 2020 (includes correspondingGraph/Chart) II-101
Table 45: World Historic Review for Pancreas Transplantation
by Geographic Region - US, Canada, Europe, Asia-Pacific
(including Japan), Latin America and Rest of World Markets
Independently Analyzed by Number of Procedures for Years 2006
through 2012 (includes corresponding Graph/Chart) II-102
Table 46: World 15-Year Perspective for PancreasTransplantation by Geographic Region - Percentage Breakdown ofNumber of Procedures for US, Canada, Europe, Asia-Pacific(including Japan), Latin America and Rest of World Markets forYears 2006, 2014 & 2020 (includes corresponding Graph/Chart) II-103
Table 47: World Recent Past, Current & Future Analysis for
Lung Transplantation by Geographic Region - US, Canada,
Europe, Asia-Pacific (including Japan), Latin America and Rest
of World Markets Independently Analyzed by Number of
Procedures for Years 2013 through 2020 (includes corresponding
Graph/Chart) II-104
Table 48: World Historic Review for Lung Transplantation byGeographic Region - US, Canada, Europe, Asia-Pacific(including Japan), Latin America and Rest of World MarketsIndependently Analyzed by Number of Procedures for Years 2006through 2012 (includes corresponding Graph/Chart) II-105
Table 49: World 15-Year Perspective for Lung Transplantation
by Geographic Region - Percentage Breakdown of Number of
Procedures for US, Canada, Europe, Asia-Pacific (including
Japan), Latin America and Rest of World Markets for Years
2006, 2014 & 2020 (includes corresponding Graph/Chart) II-106
Table 50: World Recent Past, Current & Future Analysis forCorneal Transplantation by Geographic Region - US, Canada,Europe, Asia-Pacific (including Japan), Latin America and Restof World Markets Independently Analyzed by Number ofProcedures for Years 2013 through 2020 (includes correspondingGraph/Chart) II-107
Table 51: World Historic Review for Corneal Transplantation by
Geographic Region - US, Canada, Europe, Asia-Pacific
(including Japan), Latin America and Rest of World Markets
Independently Analyzed by Number of Procedures for Years 2006
through 2012 (includes corresponding Graph/Chart) II-108
Table 52: World 15-Year Perspective for CornealTransplantation by Geographic Region - Percentage Breakdown ofNumber of Procedures for US, Canada, Europe, Asia-Pacific(including Japan), Latin America and Rest of World Markets forYears 2006, 2014 & 2020 (includes corresponding Graph/Chart) II-109III. MARKET
1. THE UNITED STATES III-1
A.Market Analysis III-1
Organ Transplants Market in the US III-1
Organ Transplants by Donor III-1
Table 53: The US Organ Donors per 1 Million Population by
Type - Kidney, Liver, Heart, Lung, and Pancreas for the
Years 2011, 2012 & 2013 (includes corresponding
Graph/Chart) III-1
Table 54: The US Bone Marrow Donor Registry: PercentageBreakdown of Adult Donors and Cord Blood Units byRace/Ethnicity (includes corresponding Graph/Chart) III-2
Table 55: The US Kidney Transplants by Donor Type -
Deceased and Living: Number of Procedures for 2012, 2013,
and 2014 E (includes corresponding Graph/Chart) III-3
Table 56: The US Kidney Transplants by Donor Type -Deceased and Living: Percentage Share Breakdown of Numberof Procedures for 2012, 2013, and 2014 E (includescorresponding Graph/Chart) III-3
Table 57: The US Liver Transplants by Donor Type - Deceased
and Living: Number of Procedures for 2012, 2013, and 2014 E
(includes corresponding Graph/Chart) III-4
Table 58: The US Liver Transplants by Donor Type - Deceasedand Living: Percentage Share Breakdown of Number ofProcedures for 2012, 2013, and 2014 E (includescorresponding Graph/Chart) III-4
Table 59: The US Heart Transplants by Donor Type - Deceased
and Living: Number of Procedures for 2012, 2013, and 2014 E
(includes corresponding Graph/Chart) III-5
Table 60: The US Heart Transplants by Donor Type - Deceasedand Living: Percentage Share Breakdown of Number ofProcedures for 2012, 2013, and 2014 E III-5
Table 61: The US Lung Transplants by Donor Type - Deceased
and Living: Number of Procedures for 2012, 2013, and 2014 E
(includes corresponding Graph/Chart) III-6
Table 62: The US Lung Transplants by Donor Type - Deceasedand Living: Percentage Share Breakdown of Number ofProcedures for 2012, 2013, and 2014 E (includescorresponding Graph/Chart) III-6
Table 63: The US Pancreas Transplants by Donor Type -
Deceased and Living: Number of Procedures for 2012, 2013,
and 2014 (Aug '14) (includes corresponding Graph/Chart) III-7
Table 64: The US Pancreas Transplants by Donor Type -Deceased and Living: Percentage Share Breakdown of Numberof Procedures for 2012, 2013, and 2014 E (includescorresponding Graph/Chart) III-7
Table 65: The US Intestinal Transplants by Donor Type -
Deceased and Living: Number of Procedures for 2012, 2013,
and 2014 (Aug '14) (includes corresponding Graph/Chart) III-8
Table 66: The US Intestinal Transplants by Donor Type -Deceased and Living: Percentage Share Breakdown of Numberof Procedures for 2012, 2013, and 2014 E (includescorresponding Graph/Chart) III-8Waiting List III-9Table 67: Waiting List of Patients for Organ Transplants byOrgan Type: as of August 2014 (includes correspondingGraph/Chart) III-9Select Market Trends III-10Rising Incidence of ESRD in the US: A Business Case forKidney Transplants III-10Table 68: ESRD Patient Prevalence in the US (2010-2015)(includes corresponding Graph/Chart) III-10Innovative Means of Organ Procurement to Increase OrganDonations III-10KPD Enables Compatibility Factor for Kidney Transplants III-10Awareness Programs to Address Shortage of Minority Donors III-11US Organ Procurement Organizations by State III-11Tissue Transplantation in the US III-13Dental Bone Graft Substitutes Market: An Overview III-13Regulatory Challenges Limit Growth in the US OrthopedicBiomaterials Market III-13Rising Incidence of Degenerative Intervertebral DiscDiseases-Opportunity Indicators for Bone Grafts III-13Osteoporosis III-14Table 69: Osteoporosis Population in the US: 2002, 2005,2008 & 2012 (includes corresponding Graph/Chart) III-14
Table 70: Breakdown of Osteoporotic Fractures by Site in
the US (includes corresponding Graph/Chart) III-15
Regulatory Bodies III-15
The United Network for Organ Sharing III-15
The American Association of Tissue Banks (AATB) III-15
National Organ Transplant Act (NOTA) III-18
Good Tissue Practices III-18
Tissue Banking Regulation III-18
FDA Regulations on Xenograft III-18
DBM-based Products in US III-18
Synthetic Bone Graft Substitutes III-19
Product Launches III-19
Strategic Corporate Developments III-21
Select Key Players III-22
B.Market Analytics III-25
By Value Sales III-25
Table 71: The US Recent Past, Current & Future Analysis for
Organ Transplantation by Organ Type - Heart, Kidney, Liver,
Pancreas, Lung and Intestine Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2013
through 2020 (includes corresponding Graph/Chart) III-25
Table 72: The US Historic Review for Organ Transplantationby Organ Type - Heart, Kidney, Liver, Pancreas, Lung andIntestine Markets Independently Analyzed with Annual SalesFigures in US$ Million for Years 2006 through 2012(includes corresponding Graph/Chart) III-26
Table 73: The US 15-Year Perspective for Organ
Transplantation by Organ Type - Percentage Breakdown of
Dollar Sales for Heart, Kidney, Liver, Pancreas, Lung and
Intestine Markets for Years 2006, 2014 & 2020 (includes
corresponding Graph/Chart) III-27
Table 74: The US Recent Past, Current & Future Analysis forTissue Transplantation Market Analyzed with Annual SalesFigures in US$ Million for Years 2013 through 2020(includes corresponding Graph/Chart) III-28
Table 75: The US Historic Review for Tissue Transplantation
Market Analyzed with Annual Sales Figures in US$ Million
for Years 2006 through 2012 (includes corresponding
Graph/Chart) III-28
By Number of Procedures III-29
Table 76: The US Recent Past, Current & Future Analysis for
Organ Transplantation by Organ Type - Heart, Kidney, Liver,
Pancreas, Lung and Intestine Markets Independently Analyzed
by Number of Procedures for Years 2013 through 2020
(includes corresponding Graph/Chart) III-29
Table 77: The US Historic Review for Organ Transplantationby Organ Type - Heart, Kidney, Liver, Pancreas, Lung andIntestine Markets Independently Analyzed by Number ofProcedures for Years 2006 through 2012 (includescorresponding Graph/Chart) III-30
Table 78: The US 15-Year Perspective for Organ
Transplantation by Organ Type - Percentage Breakdown of
Number of Procedures for Heart, Kidney, Liver, Pancreas,
Lung and Intestine Markets for Years 2006, 2014 & 2020
(includes corresponding Graph/Chart) III-31
Table 79: The US Recent Past, Current & Future Analysis forTissue Transplantation by Tissue Type - Cornea, HeartValves, Skin Grafts, Vascular Grafts, Bone Marrow and BoneGrafts Markets Independently Analyzed by Number ofProcedures for Years 2013 through 2020 (includescorresponding Graph/Chart) III-32
Table 80: The US Historic Review for Tissue Transplantation
by Tissue Type - Cornea, Heart Valves, Skin Grafts,
Vascular Grafts, Bone Marrow and Bone Grafts Markets
Independently Analyzed by Number of Procedures for Years
2006 through 2012 (includes corresponding Graph/Chart) III-33
Table 81: The US 15-Year Perspective for TissueTransplantation by Tissue Type - Percentage Breakdown ofNumber of Procedures for Cornea, Heart Valves, Skin Grafts,Vascular Grafts, Bone Marrow and Bone Grafts Markets forYears 2006, 2014 & 2020 (includes correspondingGraph/Chart) III-34
Table 82: The US Recent Past, Current & Future Analysis for
Bone Graft Transplantation by Graft Type - Autologous
Graft, Allograft and Other Materials Markets Independently
Analyzed by Number of Procedures for Years 2013 through
2020 (includes corresponding Graph/Chart) III-35
Table 83: The US Historic Review for Bone GraftTransplantation by Graft Type - Autologous Graft, Allograftand Other Materials Markets Independently Analyzed byNumber of Procedures for Years 2006 through 2012 (includescorresponding Graph/Chart) III-36
Table 84: The US 15-Year Perspective for Bone Graft
Transplantation by Graft Type - Percentage Breakdown of
Number of Procedures for Autologous Graft, Allograft and
Other Materials Markets for Years 2006, 2014 & 2020
(includes corresponding Graph/Chart) III-37
Table 85: The US Recent Past, Current & Future Analysis forBone Graft Transplantation by Application - GeneralOrthopedics, Spinal Fusions and Cranio/MaxillofacialMarkets Independently Analyzed by Number of Procedures forYears 2013 through 2020 (includes correspondingGraph/Chart) III-38
Table 86: The US Historic Review for Bone Graft
Transplantation by Application - General Orthopedics,
Spinal Fusions and Cranio/ Maxillofacial Markets
Independently Analyzed by Number of Procedures for Years
2006 through 2012 (includes corresponding Graph/Chart) III-39
Table 87: The US 15-Year Perspective for Bone GraftTransplantation by Application - Percentage Breakdown ofNumber of Procedures for General Orthopedics, SpinalFusions and Cranio/Maxillofacial Markets for Years 2006,2014 & 2020 (includes corresponding Graph/Chart) III-40
2. CANADA III-41
A.Market Analysis III-41
Canadians More Receptive to Organ Transplants III-41
Table 88: Canadian Organ Donors by Donor Type - Deceased
and Living for Years 2011& 2012 (includes corresponding
Graph/Chart) III-41
Table 89: Canadian Deceased Organ Donors by Age Group (2011 &2012) (includes corresponding Graph/Chart) III-41
Table 90: Canadian Living Organ Donors by Age Group (2011 &
2012) (includes corresponding Graph/Chart) III-42
Table 91: Canadian Multiple Organ Transplants by Type inTerms of Number of Transplants: 2012 (includescorresponding Graph/Chart) III-42Small Intestine Transplants III-43Table 92: Canadian Intestinal Transplants by TransplantType and Age Group (2003-2012) (includes correspondingGraph/Chart) III-43Waiting List III-43Table 93: Canadian Patients on Active Waiting List forOrgan Transplants by Type: 2012 (includes correspondingGraph/Chart) III-44
Table 94: Canadian Patients on Active Waiting List for
Combination Organ Transplants by Type (2012) (includes
corresponding Graph/Chart) III-44
Success Rate of Organ Transplants III-45
Table 95: Success Rate of Organ Transplants after 1-Year
(includes corresponding Graph/Chart) III-45
Favorable Growth Prospects in Bone Graft Substitutes Market III-45
B.Market Analytics III-46
Table 96: Canadian Recent Past, Current & Future Analysis
for Organ Transplantation by Organ Type - Heart, Kidney,
Liver, Pancreas and Lung Markets Independently Analyzed by
Number of Procedures for Years 2013 through 2020 (includes
corresponding Graph/Chart) III-46
Table 97: Canadian Historic Review for Organ Transplantationby Organ Type - Heart, Kidney, Liver, Pancreas and LungMarkets Independently Analyzed by Number of Procedures forYears 2006 through 2012 (includes corresponding Graph/Chart) III-47
Table 98: Canadian 15-Year Perspective for Organ
Transplantation by Organ Type - Percentage Breakdown of
Number of Procedures for Heart, Kidney, Liver, Pancreas and
Lung Markets for Years 2006, 2014 & 2020 (includes
corresponding Graph/Chart) III-48
3. EUROPE III-49A.Market Analysis III-49Table 99: European Deceased Organ Donor Per MillionPopulation (PMP) by Country for 2011, 2012 & 2013 (includescorresponding Graph/Chart) III-49
Table 100: European Living Organ Donor Per Million
Population (PMP) by Country for 2013 (includes
corresponding Graph/Chart) III-49
Table 101: European Single Organ Transplantations by SelectCountry and Organ Type: 2013 (includes correspondingGraph/Chart) III-50
Table 102: European Multi-Organ Transplantations by Select
Country and Transplant Type: 2013 (includes corresponding
Graph/Chart) III-50
Table 103: European Organ Transplantation Waiting Lists:No. of Waiting Patients by Organ Type (2012) (includescorresponding Graph/Chart) III-51Orthopedic Biomaterials Market - Overview III-51Table 104: European Bone Graft Substitutes Market (2012):Percentage Share Breakdown of Value Sales for Synthetic,Allograft, and DBM (includes corresponding Graph/Chart) III-52Synthetic Bone Graft Market Drives the BGS Market III-52Dental Biomaterials Market in Europe: An Insight III-52Medical Tourism Bodes Well for Dental Implants Market III-53Turkey - Fastest Growing Dental Implant Market III-53Competitive Scenario III-53Key Statistical Data III-54Table 105: European Market for Standard Bone Allografts(2012): Percentage Share Breakdown of Revenues by LeadingCompanies/Organizations (includes correspondingGraph/Chart) III-54
Table 106: European Market for Machined Bone Allografts
(2012): Percentage Share Breakdown of Revenues by Leading
Companies/Organizations (includes corresponding
Graph/Chart) III-54
Table 107: European Market for Demineralized Bone Matrix(2012): Percentage Market Share Breakdown of Revenues byLeading Companies/ Organizations (includes correspondingGraph/Chart) III-55
Table 108: European Market for Bone Graft Substitutes
(2012): Percentage Share Breakdown of Value Sales by
Leading Players (includes corresponding Graph/Chart) III-55
Regulatory Overview III-56
EU Directive 2003/32/EC on Bone Grafts III-56
DBM-based Products in Europe & Rest of World III-56
Focus On Select Regions III-56
The United Kingdom III-56
UK Organ Transplantation System: An Overview III-56
Organ Transplantation Statistics in the UK III-56
Table 109: The UK Organ Donors by Type (April 2012 &
April 2013) (includes corresponding Graph/Chart) III-57
Table 110: The UK Organ Transplantation by Organ Type:2012 Vs. 2013 (includes corresponding Graph/Chart) III-57
Table 111: The UK Active Transplant Waiting List by
Organ: As of April 2012 and April 2013 (includes
corresponding Graph/Chart) III-58
Table 112: The UK Deceased Donor Kidney Program (March2010-March 2013) - No. of Kidney Donors, No. of Patientson Active Waiting List, and No. of Kidney Transplants(includes corresponding Graph/Chart) III-59Corneal Transplantation in the UK III-59Spain III-59Organ Transplantation in Spain III-59France III-60Table 113: Organ Transplantations in France by Organ Type:2012 (includes corresponding Graph/Chart) III-60
Table 114: Transplant Waiting List by Organ in France:
2012 (includes corresponding Graph/Chart) III-61
Table 115: Transplants from Living Donors by Organ Type inFrance: 2012 (includes corresponding Graph/Chart) III-61Italy III-62Surge in Organ Transplants III-62Russia III-62Organ Transplantations Show a Downward Trend in Russia III-62Turkey III-62Table 116: Turkey - High PMP Numbers of Living OrganDonors/Transplants (includes corresponding Graph/Chart) III-62Akdeniz University - A World-Renowned Transplantation Center III-63Strategic Corporate Developments III-63Select Key Players III-64B.Market Analytics III-65Table 117: European Recent Past, Current & Future Analysisfor Organ Transplantation by Organ Type - Heart, Kidney,Liver, Pancreas and Lung Markets Independently Analyzed byNumber of Procedures for Years 2013 through 2020 (includescorresponding Graph/Chart) III-65
Table 118: European Historic Review for Organ
Transplantation by Organ Type - Heart, Kidney, Liver,
Pancreas and Lung Markets Independently Analyzed by Number
of Procedures for Years 2006 through 2012 (includes
corresponding Graph/Chart) III-66
Table 119: European 15-Year Perspective for OrganTransplantation by Organ Type - Percentage Breakdown ofNumber of Procedures for Heart, Kidney, Liver, Pancreas andLung Markets for Years 2006, 2014 & 2020 (includescorresponding Graph/Chart) III-67
4. ASIA-PACIFIC III-68
A.Market Analysis III-68
Table 120: Asia-Pacific Deceased Organ Donor Per Million
Population (PMP) by Country for 2011, 2012 & 2013 (includes
corresponding Graph/Chart) III-68
Table 121: Asia-Pacific Living Organ Donor Per MillionPopulation (PMP) by Country for 2011, 2012 & 2013 (includescorresponding Graph/Chart) III-68Focus on Select Regions III-69Australia - One of the Major Organ Transplant Markets inAsia-Pacific III-69Key Facts on Organ and Tissue Transplantation in Australia III-69Australia Registers Highest Success Rate in Transplantation III-69Table 122: Australia Organ Transplantations by OrganType: 2013 (includes corresponding Graph/Chart) III-69
Table 123: Australian Organ Transplants by State: 2013
(includes corresponding Graph/Chart) III-70
Thriving Orthopedic Biomaterials Market in Asia-Pacific III-70
China III-71
Organ Transplantations in China: Years 2010 to 2013 in Review III-71
Origin III-71
Transplantation Tourism in China III-72
Low Transplant Success Rate Due to Unskilled Professionals III-72
Cost Effective Transplant Procedures Lure Foreign Patients III-72
Illegal Activities for Harvesting Organs in China III-72
Regulations on Organ Transplantation III-72
Regulations on Brain Death III-73
India III-73
Overview of Renal Transplantation III-73
Transplantation Expenses in India III-74
Indian Government to Amend Organ Transplantation Rules III-74
Rise in Medical Tourism Drives Bone Grafts Market III-74
Aging Population Boosts the Indian Orthopedic Market III-74
Singapore III-75
Awareness Programs to Increase Living Kidney Donations in
Singapore III-75
Terumo Corporation (Japan) - A Key Player III-75
B.Market Analytics III-76
Table 124: Asia-Pacific Recent Past, Current & Future
Analysis for Organ Transplantation by Organ Type - Heart,
Kidney, Liver, Pancreas and Lung Markets Independently
Analyzed by
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