Does Interleukin 2 Still Have a Role in Cancer Immunotherapy? - The PROCLAIM[SM] Registry

LONDON, December 15, 2016 /PRNewswire/ --

Howard L Kaufman, Oncology & Hematology Review, 2016;12(2):77-9 DOI: https://doi.org/10.17925/OHR.2016.12.02.77

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Published recently in Oncology & Hematology Review, the peer-reviewed journal from touchONCOLOGY, Howard L Kaufman discusses the continuing role of high dose interleukin (HD IL-2), an approved therapy for the treatment of metastatic renal cell carcinoma (mRCC) and metastatic melanoma (mM) that is capable of inducing durable complete responses. The role and clinical value of HD IL-2 needs to be re-examined and better delineated in this era of emerging targeted therapy and immune checkpoint blockade therapies. This editorial presents a perspective based on recent experience using PROCLAIM^[SM], a large multicenter retrospective and prospective registry of patients receiving HD IL-2. The data confirms the potential for durable survival as first reported for HD IL-2 over two decades ago, and supports further investigation of IL-2 therapy in combination or sequence with immune checkpoint inhibitors.

The full peer-reviewed, open-access article is available here:

https://doi.org/10.17925/OHR.2016.12.02.77

Disclosure: Howard L Kaufman has served on advisory boards for Prometheus. This article is a short opinion piece and has not been submitted to external peer reviewers, but was reviewed by the Editorial Board before publication.

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