DelveInsight: Triple Negative Breast Cancer (TNBC) - The Market for TNBC in G8 Countries is Increasing at a CAGR of 18.9% for the Study Period 2016-2027

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Oct 30, 2018, 08:45 ET

LAS VEGAS, October 30, 2018 /PRNewswire/ --

Triple Negative Breast Cancer is defined as a heterogeneous breast cancer phenotype where the estrogen and progesterone receptor are negative, and there is a lack of overexpression of HER2, as assessed by immunohistochemistry (IHC), or the absence of its gene amplification, as assessed by fluorescence in situ hybridization technique.

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According to DelveInsight's assessment - based on data from recent studies and registries - shows that China accounted for 43% of the total diagnosed incident cases, followed by the US for 24% of these cases, out of all TNBC cases in G8 countries in 2016. Amongst the EU-5 countries, Germany had the highest diagnosed incidence (32%) of TNBC in the year 2016 while Spain was accountable for the least number of TNBC incident cases.

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Moving on to the market outlook of the disease, the therapeutic market for TNBC in G8 Countries is expected to increase at a CAGR of 18.9% by 2027, for the study period 2016-2027. Currently, the therapeutic market size of metastic TNBC (mTNBC) in the United States is mainly held by the systemic chemotherapies (either alone or in combination), such as Paclitaxel (Abraxane), Erbulin (Halaven), Carboplatin, Cisplatin, and Docetaxel, among others. These chemotherapies are being used off-label, both in first line as well as in second line treatment settings of TNBC patients, with variation in the dosing frequency and drug-combinations. The United States accounts for the largest market size of TNBC, in comparison to the other G8 countries i.e., EU5 countries (the United Kingdom, Germany, Italy, France, and Spain), Japan, and China. The country held a USD 84 Million market share in 2016 and this share is expected to increase by 2027.

Recently, Lynparza (Olaparib; AstraZeneca), a poly ADP ribose polymerase (PARP) inhibitor, became the first non-chemotherapy treatment for patients with an inherited BRCA mutation (also known as gBRCA or germline BRCA) and HER2-negative metastatic breast cancer, to receive the U.S. Food and Drugs Administration (USFDA) approval. Although the drug is not specifically approved for TNBC patients, it still provides a novel treatment option for mTNBC patients with BRCA mutation.

The total market size of TNBC is accounted by the market revenue generated by 1^st Line of Therapy (LoT) and 2^nd LoT. Upcoming therapies, such as Sacituzumab Govitecan (Immunomedics) in 2019, Pembrolizumab (Roche), Niraparib (Tesaro) and Rucuparib (Clovis Oncology) have the potential to create a significant positive shift in the TNBC market size during the study period (2016-2027). The launch of Sacituzumab Govitecan in US and EU will have a significant impact on the overall market. The drug will fill the void created by unavailability of targeted therapies and is expected to capture the market easily.

This report provides a detailed overview of the triple negative breast cancer and in-depth understanding of the historical and forecasted epidemiology. Additionally, it highlights the existing treatment patterns, potential upcoming drugs along with identifying the best of the market opportunities through provision of the current and forecasted market revenue, sales trends, and drug uptake during the study period from 2016-2027.

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Reasons to buy this report:

This report from DelveInsight will help to develop Business Strategies by understanding the trends shaping and driving TNBC market
Organize sales and marketing efforts by identifying the best opportunities for TNBC market
Develop understanding of the future market competition in the TNBC market

Companies Covered:

Immunomedics
Roche
Tesaro
Clovis Oncology
AstraZeneca

Drugs covered:

Sacituzumab Govitecan
Pembrolizumab
Niraparib
Rucuparib

Key Topics Covered:

1. Key Insights
2. TNBC Market Overview at a Glance
   2.1. Market Share (%) Distribution of TNBC in 2016
   2.2. Market Share (%) Distribution of TNBC in 2027
3. Disease Background and Overview: TNBC
4. Unmet Needs
5. Epidemiology and Patient Population
6. Country Wise-Epidemiology of TNBC
   6.1. The United States
   6.2. EU5 Countries
   6.3. United Kingdom
   6.4. Japan
   6.5. China
7. Treatment Practices
8. Marketed Drug Analysis
   8.1. Lynparza: AstraZeneca
   8.1.1. Drug Description
   8.1.2. Regulatory Milestones
   8.1.3. Clinical Development
   8.1.4. Safety and Efficacy
   8.1.5. Product Profile
9. Emerging Therapies
   9.1. Emerging Drugs Analysis
   9.2. Atezolizumab: Roche
   9.3. Pembrolizumab: Merck

   9.4. Ipatasertib: Roche
   9.5. Enzalutamide: Pfizer/Astellas
   9.6. Cobimetinib: Hoffman La Roche
   9.7. Rucaparib: Clovis Oncology
   9.8. Niraparib: Tesaro
   9.9. Capivasertib: AstraZeneca
10. TNBC: G8 Countries Market Analysis
11. Market Outlook by Country
12. Market Drivers
13. Market Barriers
14. Appendix
15. DelveInsight Capabilities
16. Disclaimer
17. About DelveInsight

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About DelveInsight

DelveInsight is a leading Business Consultant and Market Research Firm focused exclusively on life sciences. It supports pharma companies by providing end to end comprehensive solutions to improve their performance.

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SOURCE DelveInsight Business Research, LLP