CCHR: Another Celebrity Lost to Benzodiazepines and Opioids Mix

LOS ANGELES, Jan. 25, 2018 /PRNewswire/ -- The Los Angeles County Department of Medical Examiner-Coroner established that chart-topping singer and songwriter Tom Petty's death on Oct. 2, 2017, was from an accidental drug overdose. He suffered drug toxicity from the mixture of benzodiazepines ("benzos" or sedative-hypnotics), an antidepressant and opioids that caused cardiac arrest and multisystem organ failure.[1] The Citizens Commission on Human Rights (CCHR), a mental health watchdog, has investigated artists' deaths from taking psychotropic drugs — mixed with or without opioids — and says it's not the first celebrity that the entertainment industry, fans, and family have lost due to lethal prescription drug combinations, including Prince, Heath Ledger, Whitney Houston and more.

Toxicology tests determined that Petty had been taking two benzodiazepines — temazepam and alprazolam — the antidepressant citalopram and painkillers, including oxycodone and fentanyl. His widow, Dana Petty, and daughter, Adria, said the rock and roll legend had been prescribed opioids for a fractured hip and other chronic ailments.[2]

This is not the first celebrity the entertainment industry, fans, and family have lost due to lethal prescription drug combinations, whether prescribed or abused, and benzodiazepines are often a common denominator. They are even more dangerous because they enhance the sedative effects of opioids.[3] Consider the following iconic artists:

• Toxicology tests for another legendary singer, Prince (57), concluded that the entertainer died on April 21, 2016, from an accidental overdose of the opioid fentanyl.[4] Prince's toxicology report also revealed the presence of alprazolam in his system, according to CNN.[5]

• Soundgarden singer Chris Cornell (52) died on May 17, 2017. Although suicide was ruled as the cause of death, Cornell's wife questions the role of the benzodiazepine lorazepam.[6]

• The toxicology report for pop icon Whitney Houston (48), following her death on Feb. 11, 2012, indicated that she was "acutely intoxicated from cocaine" and a "plethora of prescription medication bottles" were found in the room, including alprazolam, according to the final report.[7]

• The Los Angeles County coroner ruled that iconic performer, Michael Jackson's (50) death was a homicide from the administration of the anesthetic drug propofol and that this drug and the sedative lorazepam were the primary drugs in Jackson's death on June 25, 2009.[8] Vials of another benzodiazepine, diazepam, were also found in his mansion.[9]

• On January 22, 2008, Heath Ledger (28) died of an accidental overdose as a result of taking a lethal combination of prescription drugs that included three benzodiazepines, diazepam, temazepam, and alprazolam. He was also taking two painkillers.[10] Heath wasn't taking the drugs for "psychiatric" reasons—like many, he used them to help him sleep and to handle a busy schedule.[11]

There's a distinct difference between Cause of Death and Means of Death. The cause is the actual event. Means is the method by which death happened. For example, the cause of death for the "King of Rock n' Roll," Elvis Presley (42), in 1977 was a heart attack. Although the coroner listed the means as "chronic heart disease," and other physical problems, the toxicology report revealed the death should be looked at in terms of the cumulative effects of prescription drugs. A prominent toxicologist also reviewed the findings and gave his opinion that "the strong probability [was] that these drugs were the major contribution to his demise."[12] The toxicology report showed numerous psychotropic drugs, including diazepam and barbiturates/sedative-hypnotics.[13]

In the two and a half years prior to his death, Elvis was prescribed an unbelievable 5,458 amphetamines, 9,567 sedatives, and 3,988 narcotics.[14] So dependent was he on these drugs that he was hospitalized at least five times for detoxification.[15]

Dr. David Sack, board certified in addiction medicine, says, "Tolerance and dependence can develop quickly. There have been reports of people who received high doses of benzodiazepines becoming physically dependent in as little as two days."[16] Combined with opioids, it's a catastrophe in the making. Dr. Sackwarns that benzodiazepines are "the danger lurking in the shadow of opiates" and that both opioids and benzodiazepines slow down body systems, particularly the respiratory and cardiovascular systems. Combining the drugs increases the effects of each exponentially, meaning that the body isn't just processing two doses, it is processing more like three or four. This multi-dose cocktail can cause breathing to stop.[17]

In the U.S., more people die from psychiatric drug overdose than heroin overdose. In 2014, 10,574 people died of heroin overdose while 15,778 died from an overdose of psychiatric drugs, nearly 50 percent more than the number of heroin overdose deaths. The biggest killers were sedatives (benzodiazepines such as alprazolam and temazepam, and Z-drugs such as zolpidem), antidepressants (such as citalopram), psychostimulants (methylphenidate, amphetamine), and antipsychotics.[18]

Fatal Rx Mix

In February 2016, researchers from the Albert Einstein College of Medicine in New York warned that benzodiazepine abuse is a growing problem in the U.S., with overdoses on the drugs increasing at a faster rate than other prescription drugs, including opioids. "Benzodiazepines have several known safety risks: in addition to overdose, they are conclusively linked to falls, fractures, motor vehicle accidents, and can lead to misuse and addiction," Dr. Marcus Bachhuber, lead author of the study told Reuters. [19]

Long-acting benzodiazepine agents are associated with accumulation which may result in sedation, cognitive impairment, and psychomotor retardation.[20] All benzodiazepines are listed as Drug Enforcement Administration (DEA) schedule IV controlled substances because of the potential for abuse, addiction, and diversion.[21]

Rockstar legend Ozzy Osbourne had been fighting substance abuse for decades when a physician prescribed 13,000 doses of 32 different drugs that included tranquilizers, amphetamines, antidepressants, and antipsychotics during one year, which turned Osbourne into an incoherent, stumbling wreck. "I was wiped out on pills," said Osbourne. "I couldn't talk. I couldn't walk. I could barely stand up. I was lumbering about like the Hunchback of Notre Dame." The pills cost $58,000 and the doctor's "services," $650,000.[22]

In 1979, Sen. Ted Kennedy called a Senate Health subcommittee hearing on the dangers of benzodiazepines in which he said the drugs "produced a nightmare of dependence and addiction, both very difficult to treat and recover from." In 2002, a group of doctors formed the Maine Benzodiazepine Study Group, which concluded: "There is no evidence supporting the long-term use of benzodiazepines for any mental health condition."[23] But the warnings have gone unheeded and profit before patients seems to have taken precedence.

Prescriptions for benzodiazepines more than tripled and fatal overdoses more than quadrupled between 1996 and 2013.[24] Despite being mostly off-patent and selling at lower generic prices, benzodiazepines accounted for nearly $509 million in sales in 2013.[25] In 2015 alone, there were about 9,000 benzodiazepine related deaths reported.[26]

"The fact that any chronic benzodiazepine users exist at all," Dr. Helen Gallagher of the University College Dublin medical school wrote in a 2013 review article in the journal Pharmacy, "highlights the fact that a convincing evidence base is being ignored by physicians, pharmacists and other healthcare providers who in essence facilitate their inappropriate use."[27]

With so many celebrities and other people's deaths due to potentially dangerous prescribing practices — and consumers believing that because the drugs are "prescribed," they are safe and can be abused — greater efforts should be made to monitor the prescribing patterns of psychiatrists and doctors, CCHR says. As with opioids, the high billing of benzodiazepines and other psychiatric drugs should be a red flag for investigators to determine who is profiting from placing some of our greatest artists and so many others at risk of addiction and death.

As a nonprofit, CCHR relies on memberships and donations to carry out its mission and actions to curb psychotropic drug use, including maintaining a Psychiatric Drug Side Effects Search Engine for consumers, parents and families to easily access information about adverse drug effects, studies and drug regulatory agency warnings. Click here to support the cause.

Contact: Amber Rauscher, [email protected] or (323) 467-4242.

References:

[1] "Heartbreaker: Tom Petty Died From An Accidental Overdose Of Opioids And Benzodiazepines," Forbes, 19 Jan. 2018, https://www.forbes.com/sites/davidkroll/2018/01/19/heartbreaker-tom-petty-died-from-an-accidental-overdose-of-medical-opioids/#7b42f73271e4.

[2] Ibid.

[3] Ibid.

[4] http://www.cnn.com/2016/06/02/health/prince-death-opioid-overdose/index.html.

[5] "Report: Pills in Prince's home mislabeled, contained fentanyl," CNN, 22 Aug. 2016, http://www.cnn.com/2016/08/22/health/prince-pills-fentanyl/index.html.

[6] "Chris Cornell's Family: Prescription Drugs May Have Influenced Suicide," Variety, 19 May 2017, http://variety.com/2017/music/news/chris-cornells-family-prescription-drugs-may-have-influenced-suicide-1202436611.

[7] "Whitney Houston's Death: 9 Surprising Details in Coroner's Report," ABC News, 5 Apr. 2012, http://abcnews.go.com/Entertainment/whitney-houston-death-surprising-details-coroners-report/story?id=16076589; http://abcnews.go.com/Entertainment/whitney-houston-death-surprising-details-coroners-report/story?id=16076589.

[8] "Drugs that killed Jackson for clinical use only, experts say," CNN, 28 Aug. 2009, http://www.cnn.com/2009/HEALTH/08/28/jackson.toxicology.drugs/index.html.

[9] http://www.news.com.au/entertainment/tv/tv-shows/michael-jackson-should-have-died-earlier-autopsy-report-reveals/news-story/557b0ea40c3fcf8c7d03df36ec268ac6

[10] "Heath Ledger's dad brings talk on prescription medication misuse to Geelong," Geelong Advertiser, 29 Mar. 2017, http://www.geelongadvertiser.com.au/news/geelong/heath-ledgers-dad-brings-talk-on-prescription-medication-misuse-to-geelong/news-story/404fb233be9af93b22164ba1ed9c2e2b

[11] Karen Mizoguchi, "Last, Ominous Conversation with Him: 'He Was Warned' About Prescription Drugs," People, 28 July 2016, http://people.com/celebrity/heath-ledgers-father-opens-up-about-actors-death-from-prescription-drugs

[12] "Elvis Presley's Death — What Really Killed the King?," Huffington Post, 2 May 2017, https://www.huffingtonpost.com/garry-rodgers/elvis-presleys-death-what_1_b_9157820.html

[13] Charles C. Thompson II & James P. Cole, The Death of Elvis, (Delacorte Press, Bantam Doubleday Dell Publishing Group, Inc., NY, 1991), p. 217.

[14] John Parker, Elvis, The Secret Files, (Anaya Publishers Ltd., London, 1993), p. 236.

[15] Ibid., Elvis, The Secret Files, p.16.

[16] David Sack M.D., "Benzodiazepines: The Danger Lurking in the Shadow of Opiates: Fatal overdoses more than quadrupled for benzodiazepines prescriptions," Psychology Today, 29 June 2017, https://www.psychologytoday.com/blog/where-science-meets-the-steps/201706/benzodiazepines-the-danger-lurking-in-the-shadow-opiates.

[17] Ibid., David Sack M.D.

[18] https://www.rehabs.com/pro-talk-articles/psychiatric-medications-kill-more-americans-than-heroin.

[19] Madeline Kennedy, "Benzodiazepine prescriptions, overdose deaths on the rise in U.S.," Reuters, 26 Feb. 2016, http://www.reuters.com/article/us-health-rxdrugs-benzodiazepine-overdos-idUSKCN0VZ2TU.

[20] https://medicaid.utah.gov/pharmacy/ptcommittee/files/Criteria%20Review%20Documents/2016/2016.11%20Benzodiazepines%20in%20Anxiety%20Drug%20Class%20Review.pdf.

[21] https://www.drugs.com/article/benzodiazepines.html.

[22] "Harsh Reality of 'Osbournes' No Laughing Matter," Los Angeles Times, 7 Dec. 2003, http://articles.latimes.com/2003/dec/07/entertainment/ca-ozzy7; Julian Coman, "Ozzy 'prescribed 13,000 doses of drugs in a year' by doctor," The Telegraph, 14 Dec. 2003, http://www.telegraph.co.uk/news/worldnews/northamerica/usa/1449437/Ozzy-prescribed-13000-doses-of-drugs-in-a-year-by-doctor.html.

[23] Markian Hawryluk, "Benzodiazepines treat anxiety, cause long-term problems," The Bulletin, 1 June 2014, http://www.bendbulletin.com/localstate/2119922-151/benzodiazepines-treat-anxiety-cause-long-term-problems.

[24] David Sack, "Benzodiazepines: The Danger Lurking in the Shadow of Opiates," Psychology Today, 29 Jun. 2017, https://www.psychologytoday.com/blog/where-science-meets-the-steps/201706/benzodiazepines-the-danger-lurking-in-the-shadow-opiates.

[25] Markian Hawryluk, "Benzodiazepines treat anxiety, cause long-term problems," The Bulletin, 1 June 2014, http://www.bendbulletin.com/localstate/2119922-151/benzodiazepines-treat-anxiety-cause-long-term-problems.

[26] "We Need to Talk About Our Generation's (Alprazolam) Problem," 23 Aug. 2017, https://www.vice.com/en_us/article/evvama/we-need-to-talk-about-our-generations-xanax-problem; "Overdose Death Rates," National Institute of Drug Abuse, Sept. 2017, https://www.drugabuse.gov/related-topics/trends-statistics/overdose-death-rates.

[27] Markian Hawryluk, "Benzodiazepines treat anxiety, cause long-term problems," The Bulletin, 1 June 2014, http://www.bendbulletin.com/localstate/2119922-151/benzodiazepines-treat-anxiety-cause-long-term-problems.

SOURCE Citizens Commission on Human Rights International