CAR T-Cell Study Enabled by 10x Genomics Single Cell Technology Published in Nature Medicine

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Jul 05, 2023, 19:30 ET

Data Uncovers New Gene Signature to Help Understand Persistence in CAR T-cells

PLEASANTON, Calif., July 5, 2023 /PRNewswire/ -- 10x Genomics, Inc. (Nasdaq: TXG), a leader in single cell and spatial biology, announced today that its single-cell genomic technologies were used in a study published in the journal Nature Medicine about new gene signatures that explain why some children with leukemia have longer remission after CAR T-cell therapy. The collaborative research project was conducted by researchers from Great Ormond Street Hospital (GOSH), the Wellcome Sanger Institute and the UCL Great Ormond Street Institute of Child Health (UCL GOS ICH).

Researchers conducting the study, "Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia," used Chromium Single Cell Gene Expression technologies and T-cell receptor sequencing of samples to look at what makes the long-lasting CAR T-cells unique. These helped identify a genetic signature of the CAR T-cells that persisted in the body long-term – an important predictor of durable remission. The data was from the CARPALL trial, which used molecular features and clonal dynamics of CD19 CAR T-cells of 10 children with relapsed or refractory B-cell acute lymphoblastic.

Ben Hindson, Co-founder and Chief Scientific Officer at 10x Genomics, said, "Single cell genomics is a powerful tool that is transforming cancer research and our understanding of health and disease. We are so proud to have 10x technologies behind this incredible breakthrough. We celebrate the achievements of the research team and the selfless dedication of the families who made this study possible. We look forward to continuing to give researchers the technologies needed to fuel new biological discoveries and ultimately help improve patient care."

Using Chromium Single Cell Gene Expression products, researchers identified a unique double negative phenotype of long-lasting CAR T-cells, which provides insights into how these cells survive and remain active in the body. These key genes appeared to enable the CAR T-cells to persist and therefore allow the children to live cancer free long-term. The findings may lead to discovering new biomarkers that could predict the long-term durability of CAR T-cell therapies and provide better treatment options for patients.

Dr. Sam Behjati, co-senior author, Group Lead and Wellcome Senior Research Fellow at the Wellcome Sanger Institute and Honorary Consultant Paediatric Oncologist at Addenbrooke's Hospital, Cambridge, said, "This study is a fantastic step forward in our understanding of CAR T-cell persistence and illustrates the power of collaborative science and combining pioneering clinical research with cutting-edge genomic science. It is crucial that we continue to develop and build on these new treatments to help more children with leukaemia across the world."

About 10x Genomics
10x Genomics is a life science technology company building products to interrogate, understand and master biology to advance human health. Our integrated solutions include instruments, consumables and software for analyzing biological systems at a resolution and scale that matches the complexity of biology. 10x Genomics products have been adopted by researchers around the world including in all of the top 100 global research institutions as ranked by Nature in 2021 based on publications and all of the top 20 global pharmaceutical companies by 2021 research and development spend and have been cited in over 5,000 research papers on discoveries ranging from oncology to immunology and neuroscience. Our patent portfolio comprises more than 1,750 issued patents and patent applications.

About the Wellcome Sanger Institute
The Wellcome Sanger Institute is a world leading genomics research centre. We undertake large-scale research that forms the foundations of knowledge in biology and medicine. We are open and collaborative; our data, results, tools and technologies are shared across the globe to advance science. Our ambition is vast – we take on projects that are not possible anywhere else. We use the power of genome sequencing to understand and harness the information in DNA. Funded by Wellcome, we have the freedom and support to push the boundaries of genomics. Our findings are used to improve health and to understand life on Earth. Find out more at www.sanger.ac.uk or follow us on Twitter, Facebook, LinkedIn and on our Blog.

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