Arginine Bicarbonate-Calcium Carbonate Soft Chews Seal Open Dentinal Tubules in Hydraulic Conductance Test
In Vitro Test Suggests Soft Chews Could be Effective Treatment for Dentinal Sensitivity
ROSLYN HEIGHTS, N.Y., June 9, 2015 /PRNewswire/ -- Ortek Therapeutics, Inc. announced today that their arginine bicarbonate, calcium carbonate containing soft chews were significantly effective in sealing open dentinal tubules in an in vitro hydraulic conductance test conducted at Stony Brook University School of Dental Medicine.
Dentinal hypersensitivity is a common problem among adults that manifests as sharp pain in teeth upon exposure to thermal, evaporative, tactile, osmotic or chemical stimuli. Hypersensitivity can occur when there is clinical exposure of open dentinal tubules of a tooth or teeth.
The use of the hydraulic conductance method is a well-established test for evaluating an oral care product's ability to treat dentinal sensitivity. The purpose of this test was to evaluate the reduction of dentinal fluid flow after a single fingertip application of an arginine bicarbonate, calcium carbonate soft chew confection applied to dentin disks in a dentinal tubular plugging simulator device.
Extracted sound human molar teeth, without any restorations, were sliced horizontally to produce tooth slices for dentinal hypersensitivity testing. Mid-coronal dentin discs were obtained and then etched with citric acid, thereby opening the dental tubular orifices. Dentinal discs were then removed from the acid, rinsed thoroughly in deionized water and then placed in the plastic hydraulic chamber of the testing device.
The soft chew confection was softened by mixing with centrifuged whole saliva supernatant donated by a human subject. The resulting softened product was applied manually by direct fingertip application to the exposed surface of the dentin disc positioned in the device chamber. Fluid flow was recorded every 5 minutes for successive 30 minute intervals, before and 90 minutes after a single application.
According to the hydrodynamic theory for tooth sensitivity, dentinal hypersensitivity is related to the movement of inter-tubular fluid through the test apparatus. The results of this evaluation demonstrate the ability of an arginine bicarbonate, calcium carbonate soft chew confection to physically seal open dentinal tubules. It was demonstrated that the soft chew significantly reduced the mobility of tubular fluid by occluding the orifices of the dentinal tubules. This was observed after a single fingertip application.
Ortek Therapeutics, Inc. is a global leader in developing cutting-edge oral care innovations that will improve the quality of life for people everywhere.
SOURCE Ortek Therapeutics, Inc.
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