Insmed Announces First Patient Dosed in TARGET-NTM Phase 2 Clinical Trial of ARIKACE® in Patients with Non-Tuberculous Mycobacteria (NTM) Lung Disease

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Jun 27, 2012, 08:00 ET

MONMOUTH JUNCTION, N.J., June 27, 2012 /PRNewswire/ -- Insmed Incorporated (Nasdaq CM: INSM), a biopharmaceutical company, today announced that the first patient has been dosed in the Company's U.S. phase 2 clinical study of ARIKACE® (liposomal amikacin for inhalation) in patients with non-tuberculous mycobacterial (NTM) lung disease entitled TARGET-NTM (Treatment with ARIKACE to Realize Greater Efficacy Trial).

"The prevalence of this debilitating chronic disease continues to grow, and the current NTM treatment paradigm lacks acceptable treatment options," said Mark Rolfe, M.D. FCCP, President of New Lung Associates P.A., Medical Director of the Lung Transplant and Adult Cystic Fibrosis Programs at Tampa General Hospital, where the first patient in the trial was dosed. "Many of these patients are treated with combinations of antibiotics which have shown limited efficacy and are poorly tolerated, especially when given long term. It has been many years since we had a promising new treatment to study in these patients, and I believe that if ARIKACE is successful in clinical trials, such as this one, then it has the potential to become an important treatment option for patients suffering from NTM lung infections."

The Principal Investigator of the study is Kenneth N. Olivier, M.D., M.P.H., staff pulmonologist in the Laboratory of Clinical Infectious Diseases at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

"The dosing of the first patient in this clinical trial is an important step in the development of ARIKACE," said Timothy Whitten, President and CEO of Insmed. "Individuals who have NTM lung infections are part of a substantially underserved patient population, and if ARIKACE is shown effective in this indication, it could prove to be a significant advancement in the treatment of this orphan disease."

About Insmed

Insmed Incorporated is a biopharmaceutical company focused on the development of innovative inhaled pharmaceuticals for the site-specific treatment of serious lung diseases. Insmed's primary focus is on the development of inhaled antibiotic therapy delivered via proprietary advanced liposomal pulmonary technology in areas of high unmet need. For more information, please visit http://www.insmed.com.

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SOURCE Insmed Incorporated