Clinical Study Results Show Nutrition 21's Chromax(R) Chromium Picolinate Improves Cognitive-Cerebral Function in Older Adults

PURCHASE, N.Y., May 6 /PRNewswire-FirstCall/ -- Nutrition 21, Inc. (OTC Bulletin Board: NXXI), the developer and marketer of nutritional ingredients for the dietary supplement, functional food and beverage markets announced today the publication of results of a human clinical study showing that its Chromax® chromium picolinate improved memory function in elderly adults with early memory decline.  The double-blind, placebo-controlled clinical study was conducted by researchers at the University of Cincinnati - College of Medicine.   The study, entitled "Improved cognitive-cerebral function in older adults with chromium supplementation," was published in the journal Nutritional Neuroscience (2010 Jun; 13 (3):116-22).

Recent research in the areas of cognitive brain function and Alzheimer's disease has shown significant links to glucose metabolism.  James Komorowski, M.S., C.N.S., vice president – Research and Development for Nutrition 21, stated, "In the past, we have seen the benefits of Chromax chromium picolinate in improving glucose metabolism in muscle and fat cells; especially in people with diabetes.  But these new study results support the findings that Chromax chromium picolinate can also improve glucose metabolism in the brain, resulting in improved brain function".  

Michael A. Zeher, president and chief executive officer of Nutrition 21, commented, "The results of this study further expand the clinical benefits of Chromax chromium picolinate and open the door for a new line of product applications covered by our expanding patent portfolio.  This study is another example of breakthrough clinical research supported by Nutrition 21."  

Study Design and Results:

The study enrolled 26 older adults (12 men, 14 women) with indications of early memory decline, representing increased risk of neurodegeneration and Alzheimer's disease.  Study subjects were randomly assigned in a double-blind manner to receive daily chromium picolinate (1,000 mcg chromium) or placebo capsules for 12 weeks.  Results of the memory tests showed that the chromium-treated subjects made significantly fewer errors in memory.  Thirteen subjects (9 chromium-treated and 4 placebo-treated) also completed pre- and post-intervention fMRI brain scans during performance of certain memory tasks. Chromium-treated subjects showed increased brain activation at 12 weeks relative to pre-treatment as compared with unchanged activation for the placebo-treated subjects.

About Nutrition 21

Nutrition 21, Inc., headquartered in Purchase, NY, is a nutritional bioscience company and holds over 30 issued and pending patents associated with chromium picolinate as well as combinations of chromium compounds with other dietary supplement ingredients.  Its ingredients are sold to leading dietary supplement, functional food and beverage manufacturers.  For more information please visit http://www.nutrition21.com.

Safe Harbor Provision

This press release may contain certain forward-looking statements. The words "believe," "expect," "anticipate" and other similar expressions generally identify forward-looking statements. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of their dates. These forward-looking statements are based largely on the Company's current expectations and are subject to a number of risks and uncertainties, including without limitation: the effect of the expiration of patents; regulatory issues; uncertainty in the outcomes of clinical trials; changes in external market factors; changes in the Company's business or growth strategy or an inability to execute its strategy due to changes in its industry or the economy generally; the emergence of new or growing competitors; various other competitive factors; and other risks and uncertainties indicated from time to time in the Company's filings with the Securities and Exchange Commission, including its Form 10-K/A for the year ended June 30, 2009. Actual results could differ materially from the results referred to in the forward-looking statements. In light of these risks and uncertainties, there can be no assurance that the results referred to in the forward-looking statements contained in this press release will in fact occur. Additionally, the Company makes no commitment to disclose any revisions to forward-looking statements, or any facts, events or circumstances after the date hereof that may bear upon forward-looking statements.

SOURCE Nutrition 21, Inc.

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