Chronic Kidney Disease Competitive Landscape Report 2023: Comprehensive Insights About 75+ Companies and 95+ Drugs

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May 05, 2023, 18:30 ET

DUBLIN, May 5, 2023 /PRNewswire/ -- The "Chronic Kidney Disease - Competitive landscape, 2023" report has been added to ResearchAndMarkets.com's offering.

This report provides comprehensive insights about 75+ companies and 95+ drugs in Chronic Kidney Disease Competitive landscape. It covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

In March 2023, POXEL SA, announced the publication of preclinical results in autosomal dominant polycystic kidney disease (ADPKD) for PXL770, a novel, first-in-class direct adenosine monophosphate-activated protein kinase (AMPK) activator. For the first time, POXEL SA showed beneficial effects of a direct and selective AMPK activator in preclinical ADPKD models from three species mouse, human, and dog. These results confirm the potential utility of AMPK activation for this disease and support the development of PXL770 in a Phase 2 clinical program for ADPKD.

In February 2023, AstraZeneca announced the successful completion of the acquisition of CinCor Pharma, Inc. The acquisition bolsters AstraZeneca's cardiorenal pipeline by adding baxdrostat (CIN-107), an aldosterone synthase inhibitor (ASI) for blood pressure lowering in treatment-resistant hypertension, to its cardiorenal portfolio.

In January 2023, The U.S. Food and Drug Administration (FDA) has accepted a supplemental New Drug Application (sNDA) for Jardiance (empagliflozin) tablets, which is being investigated as a potential treatment to reduce the risk of kidney disease progression and cardiovascular death in adults with chronic kidney disease (CKD), Boehringer Ingelheim and Eli Lilly and Company announced.

In November 2022, The Medical Research Council Population Health Research Unit (MRC PHRU) at the University of Oxford, which designed, conducted and analyzed EMPA-KIDNEY in a scientific collaboration with Boehringer Ingelheim and Eli Lilly and Company, announced that EMPA-KIDNEY phase III clinical trial met its primary endpoint by demonstrating a significant kidney and cardiovascular benefit for adults living with chronic kidney disease (CKD). When treated with Jardiance (empagliflozin), the risk of kidney disease progression or cardiovascular death was significantly reduced by 28% vs. placebo (HR; 0.72; 95% CI 0.64 to 0.82; P< 0.0001).

In October 2022, Revelation Biosciences Inc. announced positive results in a preclinical model of acute kidney injury (AKI), chronic kidney disease (CKD). Treatment with REVTx-300 significantly reduced renal cortical fibrosis in a dose dependent manner in the medium and high dose groups (21.7% reduction (p < 0.05) and 29.3% (p < 0.05), respectively) and was comparable to a known TGF inhibitor of fibrosis used as a positive control (38.1% reduction (P < 0.05)).

In October 2022, French Biopharma Company, Poxel SA announced the U.S. Food and Drug Administration (FDA) has granted orphan drug designation (ODD) to PXL770 for the treatment of patients with autosomal-dominant polycystic kidney disease (ADPKD). PXL770 is a novel, first-in-class direct adenosine monophosphate-activated protein kinase (AMPK) activator - and is also a phase 2 ready ADPKD asset, subject to additional financing.

In-depth Commercial Assessment: Chronic Kidney Disease Collaboration Analysis by Companies

The Report provides in-depth commercial assessment of drugs that have been included, which comprises collaboration, agreement, licensing and acquisition - deals values trends. The sub-segmentation is described in the report which provide company-company collaboration (licensing/partnering), company academic collaboration and acquisition analysis in tabulated form.

Current Treatment Scenario and Emerging Therapies:

How many companies are developing Chronic Kidney Disease drugs?
How many Chronic Kidney Disease drugs are developed by each company?
How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Chronic Kidney Disease?
What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Chronic Kidney Disease therapeutics?
What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
What are the clinical studies going on for Chronic Kidney Disease and their status?
What are the key designations that have been granted to the emerging and approved drugs?

Key Players

Boehringer Ingelheim
Eli Lilly and Company
Reata Pharmaceuticals
Novo Nordisk
KBP Biosciences
AstraZeneca
Allena Pharmaceuticals
SCOHIA PHARMA
DiaMedica Therapeutics
CinCor Pharma
Galapagos NV
Sentien Biotechnologies, Inc.
Regeneron Pharmaceuticals
UnicoCell Biomed
OccuRx
Pharmicell
Lisata Therapeutics
Unicycive Therapeutics
Senda Biosciences
Sarfez Pharmaceuticals
Rege Nephro
Orgenesis
GNI Group
Algomedix
Maze Therapeutics
Chinook Therapeutics
Angion Biomedica Corp
Arch Biopartners
Scohia Pharma
Algernon Pharmaceuticals
TICEBA GmbH

Key Products

Empagliflozin
Bardoxolone methyl
Ziltivekimab
KBP-5074
AZD9977
ALLN-346
BI-685509
SCO-792
DM199
Baxdrostat
GLPG2737
SBI-101
REGN5459
ELIXCYTE
FT011
Cellgram-CKD
CLBS201
UNI-494
Research Program
SZ007
Renal progenitor cells
MSCKD
F351

Research programme: TRPC6 antagonist

APOL1 Programme

Research and discovery programs: severe chronic kidney disease

ROCK2 Inhibitor
LSALT peptide
SCO-116
Repirinast
Polycystic kidney disease (PKD)

For more information about this report visit https://www.researchandmarkets.com/r/9mfl4c

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