Cardiac Dimensions Announces Presentation of Two-Year Efficacy Data From TITAN Clinical Trial

KIRKLAND, Wash., Nov. 7, 2011 /PRNewswire/ -- Cardiac Dimensions®, Inc. today announced that an update to its landmark TITAN clinical trial will be given as part of the 23rd annual Transcathether Cardiovascular Therapeutics (TCT) Conference being held at the Moscone Center in San Francisco.  Steven L. Goldberg, M.D., the Company's Chief Clinical Officer will deliver a presentation entitled, Cardiac Dimensions CARILLON XE2: Foundational Results and Design Iteration Toward a Pivotal Clinical Trial.  His presentation will be given on Wednesday, November 9 at 2:40 PM PST in Room 135 as part of an in-depth session focused on next generation transcatheter mitral valve therapies.

TITAN was a prospective, non-randomized, double-arm study evaluating CARILLON in functional mitral regurgitation (FMR) patients. Results from the trial will be highlighted as part of the talk, including presentation of two-year clinical efficacy data. The data demonstrate early and sustained improvements in functional capacity, as well as significant improvements in mitral regurgitation and left ventricular dilation.    

"CARILLON offers a novel approach to the treatment of FMR and with the availability of two-year data indicating clinical efficacy, the potential applications of this therapy will be better understood," stated Dr. Goldberg.  "As a practicing cardiologist, I see first hand how challenging it can be to treat these patients given their limited treatment options. It is encouraging to see the initial positive experiences with CARILLON become validated with longer-term data. The clinical data suggest that CARILLON is a treatment modality with compelling prospects for counterbalancing the deleterious effects of FMR."

About CARILLON® Mitral Contour System™

Cardiac Dimensions' CARILLON Mitral Contour System combines a proprietary, implantable device with a percutaneous catheter delivery system. The implantable device consists of a proximal anchor and a distal anchor connected by a shaping ribbon. Utilizing the heart's natural structures, the device is intended to reduce mitral annulus dilatation upon deployment, thereby significantly reducing functional mitral regurgitation (FMR). Rapidly delivered via the venous vasculature, CARILLON has the potential to treat most heart failure patients in a minimally invasive fashion. Early clinical data suggest that usage is associated with significant reduction in FMR, and significant improvement in functional capacity and quality of life.

About Functional Mitral Regurgitation

More than 20 million people worldwide have heart failure, most of whom also suffer from functional mitral regurgitation (FMR). FMR typically results from the dilation of the left ventricle, which is the main pumping chamber in the heart. As the left ventricle increases in size, the mitral valve also expands. This dimensional increase leads to mitral regurgitation, which significantly reduces the amount of blood flow out of the left ventricle and on to the body and its organs. FMR has been associated with high rates of mortality, reduced functional capacity, poor quality of life and an increase in patient hospitalizations. Current mainstream therapies to address FMR are limited. A majority of patients become refractory to medical therapy over time and traditional surgical intervention is associated with high rates of operative morbidity and mortality.

About Cardiac Dimensions®, Inc.

Cardiac Dimensions is a leader in the development of innovative, minimally invasive treatment modalities to address heart failure and related cardiovascular conditions. The company's initial technology platform, the CARILLON® Mitral Contour System™ has been designed to address functional mitral regurgitation, utilizing a novel percutaneous approach. Cardiac Dimensions is based in Kirkland, Washington. For more information, visit the company's web site: http://www.cardiacdimensions.com.

Cardiac Dimensions and CARILLON are registered trademarks of Cardiac Dimensions, Inc., and Mitral Contour System is a trademark of Cardiac Dimensions, Inc.

SOURCE Cardiac Dimensions, Inc.

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