Blood pressure lowering effect of melatonin-Study results presented at American Heart Association hypertension sessions

ORLANDO, Fla., Dec. 7, 2016 /PRNewswire/ -- A study to determine the blood pressure lowering effect of melatonin in both younger and older normotensive and pre-hypertensive individuals was conducted at Thomas Jefferson University in Philadelphia, Penn., and presented as a poster presentation at the recent American Heart Association hypertension sessions.

The study, Blood Pressure Lowering Effect of Melatonin in a Mixed Cohort of Younger and Older Non-Hypertensive Adults, was conducted under the direction of Cynthia Cheng, MD, PhD and Scott W. Keith, PhD, from the Departments of Family and Community Medicine/Biostatistics, Jefferson Medical College, and Nalaka S. Gooneratne, MD, M.Sc., of the Department of Medicine, University of Pennsylvania, Philadelphia, Penn.

Two successive blood pressure readings, with a one-minute interval between measurements, were taken from 23 participants in the seated position following 10 minutes of rest. A Dinamap ProCare 100 automatic blood pressure monitor with appropriate cuff size was used on the left arm of all study participants. All subjects had office and 24-hour ambulatory BP measured before and after dosing of 9 mg controlled release melatonin (melatonin group) or usual care (control group) for six weeks.

Mean systolic office pressure and 24-hour diastolic pressure were significantly lower following melatonin administration in both younger and older patients. Results were even more striking. The findings were of greater magnitude in the older patients.

The study concluded that these findings suggest possible future use of melatonin for lowering blood pressure in younger and older non-hypertensive individuals.

Support for the study was from a grant award provided by the National Heart, Lung and Blood Institute. The work was also supported by the Life Extension Foundation, Fort Lauderdale, Fla.

For complete study information contact Dr. Steven Hirsh, director of clinical research, Life Extension Clinical Research, Inc. at [email protected].

SOURCE Life Extension

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