A New Ulcerative Colitis Biologic With a Novel Mechanism of Action Would Earn Similar Patient Share in Europe and U.S.

WALTHAM, Mass., Jan. 4 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that a biological therapy with a mechanism of action other than tumor necrosis factor alpha (TNF-alpha) inhibition for the treatment of moderate to severe ulcerative colitis, would earn a 25 percent patient share according to surveyed U.S. gastroenterologists. Similarly, in Europe, such an agent would also earn 25 percent patient share according to surveyed European gastroenterologists. These findings highlight the significant opportunity for a biological therapy with a novel mechanism of action to serve as an alternative to Centocor Ortho Biotech/Merck/Mitsubishi Tanabe Pharma's Remicade (infliximab) for the treatment of moderate to severe ulcerative colitis.

The new report entitled Ulcerative Colitis: Gastroenterologists Identify Emerging Drugs That Will Challenge the Benchmark Therapy Infliximab for Moderate to Severe UC finds that two emerging TNF-alpha inhibitors--Abbott/Eisai's Humira and Centocor Ortho Biotech/Merck/Mitsubishi Tanabe Pharma/Janssen's Simponi--will earn Decision Resources' proprietary clinical gold standard status for ulcerative colitis in 2013 following their approval for the indication. Both Humira and Simponi have competitive advantages over the sales-leader--Remicade--in efficacy, delivery and safety and tolerability.

"Although clinical trial data are limited, interviewed experts believe that both Humira and Simponi's fully human composition will translate into incremental advantages in efficacy for maintenance of remission and maintenance of response compared to Remicade, which is a chimeric monoclonal antibody," said Decision Resources Analyst Kathryn Benton.

About the Report

Ulcerative Colitis: Gastroenterologists Identify Emerging Drugs That Will Challenge the Benchmark Therapy Infliximab for Moderate to Severe UC is a DecisionBase 2010 report. DecisionBase 2010 is a decision-support tool that provides in-depth analysis of unmet need, physician expectations of new therapies and commercial dynamics to help pharmaceutical companies optimize their investments in drug development.

About Decision Resources

Decision Resources (www.decisionresources.com) is a world leader in market research publications, advisory services and consulting designed to help clients shape strategy, allocate resources and master their chosen markets. Decision Resources is a Decision Resources, Inc. company.

About Decision Resources, Inc.

Decision Resources, Inc. is a cohesive portfolio of companies that offers best-in-class, high-value information and insights on important sectors of the healthcare industry. Clients rely on this analysis and data to make informed decisions. Please visit Decision Resources, Inc. at www.DecisionResourcesInc.com.

All company, brand, or product names contained in this document may be trademarks or registered trademarks of their respective holders.

    For more information, contact:

    Decision Resources                        Decision Resources, Inc.
    Gisselle Morales                          Elizabeth Marshall
    781-296-2691                              781-296-2563
    [email protected]                   [email protected]

SOURCE Decision Resources

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