Sleep Aids : Technologies and Global Markets

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Jul 07, 2014, 08:19 ET

NEW YORK, July 7, 2014 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Sleep Aids : Technologies and Global Markets

http://www.reportlinker.com/p02212012/Sleep-Aids--Technologies-and-Global-Markets.html

Research on the working of the human brain in relation to sleep is a fairly new area, with many new and novel theories. The discovery of new mechanisms and chemicals in the brain has provided expanding avenues for research and development (R&D) of products that are likely to alter the course of sleep disorders or modify its outcome. This BCC Research study analyzes the current therapies for sleep disorders and new therapies that are in the pipeline. It also discusses products, trends, new developments and compensation issues that are currently affecting or are likely to affect the market soon. Moreover, all markets are further broken down into specific types of products, measuring current and potential market size, identifying current and potential market drivers, detailing from 2013, 2014 and 2019, and assessing the competitors in the market and their shares in respective markets.

Use this report to:
- Receive the latest information on leading products and R&D initiatives in the area of sleep disorders.
- Receive analysis of the current therapies for sleep disorders and new therapies that are in the pipeline.
- Learn about the causes and available treatments for sleep disorder sufferers.
- Receive an extensive review of the market leading firms in the industry.

Highlights
- The global market for sleep aids totaled $54.9 billion in 2013. This market is estimated to grow at a compound annual growth rate (CAGR) of 5.6% to reach $58.5 billion in 2014 and $76.7 billion by 2019.
- The global market for mattresses and pillows is expected to increase from $29.7 billion in 2014 to $34.1 billion in 2019, a CAGR of 2.8% from 2014 to 2019.
- The global market for sleep apnea devices is expected to increase from $13.8 billion in 2014 to $23.6 billion in 2019, a CAGR of 11.3% from 2014 to 2019.

INTRODUCTION

STUDY GOALS AND OBJECTIVES
Insomnia, sleep apnea, restless leg syndrome (RLS), bruxism, narcolepsy and sleepwalking are all serious sleep disorders that bring about negative health consequences. Often undiagnosed and thus not treated, sleep disorders can not only take a toll on personal health but can also adverse effects on personal relationships and reduce worker productivity. In examining the steep increase in a variety of sleep disorders, this report will analyze the causes and available treatments for sleep disorder sufferers. This report describes in detail the overall market for sleep aids and then gives an account of the segment revenues.

REASONS FOR STUDY
This BCC Research study provides the latest highlights in the exciting area of sleep disorders. Research on the working of the human brain in relation to sleep is a fairly
new area, with many new and novel theories. The discovery of new mechanisms and chemicals in the brain has provided expanding avenues for research and development
(R&D) of products that are likely to alter the course of sleep disorders or modify the outcome. This study analyzes the current therapies for sleep disorders and newtherapies that are in the pipeline. The report provides the latest information on leading products and R&D initiatives in the area of sleep disorders. Moreover, the report gives
an extensive review of the market leading firms in this sector.

SCOPE OF STUDY
This analysis primarily focuses on the following sleep disorders:
- Insomnia.
- Sleep apnea.
- RLS.
- Bruxism.
- Narcolepsy.
- Sleepwalking.

The report discusses products, trends, new developments and compensation issues that are currently affecting or are likely to affect the market soon. Analyses are
provided for each of the key companies in the major and minor market segments. The sleep aids and diagnostic centers discussed in this report include:
- Medications.
- Prescriptions.
- Over-the-counter (OTC).
- Herbal remedies.
- Sleep laboratories.
- Sleep apnea devices.
- Mattresses and pillows.

All markets are further broken down into specific types of products that are discussed in detail, measuring current and potential market size, identifying current and potential
market drivers, detailing from 2013, 2014 and 2019, and assessing the competitors in the market and their shares in respective markets.

METHODOLOGY AND INFORMATION SOURCES
Both primary and secondary research methodologies were used in preparing this research report. The information and analysis presented are based on extensive first-hand interviews with primary executives, product managers, clinical specialists and doctors involved in the sleep disorders arena. Background information was obtained from various government, business, medical journal and trade magazines sources. Interviews were also used to confirm and/or adjust market size and market share estimates, as well as to formulate market projections.

TABLE OF CONTENTS

CHAPTER 1 INTRODUCTION 2
STUDY GOALS AND OBJECTIVES 2
REASONS FOR STUDY 2
SCOPE OF STUDY 2
METHODOLOGY AND INFORMATION SOURCES 3
ANALYST'S CREDENTIALS 3
RELATED BCC RESEARCH REPORTS 3
BCC RESEARCH WEBSITE 3
DISCLAIMER 4

CHAPTER 2 EXECUTIVE SUMMARY 6
SUMMARY TABLE A GLOBAL MARKET FOR SLEEP AIDS BY PRODUCT TYPE,
THROUGH 2019 ($ BILLIONS) 8
SUMMARY FIGURE A GLOBAL MARKET FOR SLEEP AIDS BY PRODUCT TYPE,
2013-2019 ($ BILLIONS) 8
SUMMARY TABLE B GLOBAL MARKET SHARES FOR SLEEP AIDS: TECHNOLOGIES
AND MARKETS BY REGION, 2013-2019 (%) 9
SUMMARY FIGURE B GLOBAL MARKET SHARES FOR SLEEP AIDS: TECHNOLOGIES
AND MARKETS BY REGION, 2019 (%) 9

CHAPTER 3 NORMAL SLEEP, SLEEP DISORDERS AND TREATMENTS: AN OVERVIEW 11
NORMAL SLEEP 11
TABLE 1 NORMAL SLEEP ARCHITECTURE 11
PHYSIOLOGY OF NORMAL SLEEP 12
FIGURE 1 PROGRESSION OF SLEEP STATES ACROSS A SINGLE NIGHT IN YOUNG
ADULT 12
NREM and REM Sleep Cycles 12
Four Stages of NREM Sleep 13
FIGURE 2 CHARACTERISTIC EEG ACTIVITY OF EACH OF THE FOUR STAGES OF
NREM SLEEP 13
Stage 1 Sleep 13
Stage 2 Sleep 13
Stage 3 and 4 Sleep 14
REM Sleep 14
TABLE 2 PHYSIOLOGICAL CHANGES DURING NREM AND REM SLEEP 14
PHYSIOLOGY DURING SLEEP 15
FACTORS AFFECTING SLEEP 16
Light 16
Jet Lag and Shift Work 16
Pain, Anxiety and Other Medical Conditions 16
Medications and Other Substances 17
SLEEP DURATION BY AGE 17
FIGURE 3 SLEEP DURATION BY AGE (HOURS) 17

CHAPTER 4 SLEEP DISORDERS AND TREATMENTS: AN OVERVIEW 20
INSOMNIA 20
INSOMNIA: SYMPTOMS AND CAUSES 20
INSOMNIA: DIAGNOSIS AND SELF TESTS 21
INSOMNIA: TREATMENT 22
SLEEP APNEA 22
SLEEP APNEA: SYMPTOMS AND RISK FACTORS 22
SLEEP APNEA: DIAGNOSIS 23
SLEEP APNEA: TREATMENT 23
NARCOLEPSY 24
NARCOLEPSY: SYMPTOMS 25
NARCOLEPSY: TREATMENT 26
RESTLESS LEG SYNDROME 26
RESTLESS LEG SYNDROME: CAUSES AND SYMPTOMS 26
RESTLESS LEG SYNDROME TREATMENT 27
PARASOMNIAS 28
PARASOMNIAS: SYMPTOMS 28
PARASOMNIAS: DIAGNOSIS AND TREATMENT 30
SHIFT WORK DISORDER 30
SHIFT WORK DISORDER: TREATMENT 30
SNORING 31
SNORING: TREATMENTS 31
JET LAG 31
JET LAG: SYMPTOMS 32
JET LAG: TREATMENT 32

CHAPTER 5 SLEEP DISORDERS: AN OVERVIEW OF DISEASE MANAGEMENT 34
HOME SLEEP TESTING 34
PROCESS OF HOME SLEEP TESTING 34
IN-LAB SLEEP STUDY 35
IN-LAB SLEEP STUDY: TESTING PROCESS 35
MULTIPLE SLEEP LATENCY TEST 35
MSLT: TESTING PROCESS 35
CPAP TITRATION STUDY 36
PROCESS OF CPAP TITRATION STUDY 36
CONTINUOUS PASSIVE AIRWAY PRESSURE THERAPY 37
ORAL APPLIANCE THERAPY 37
SURGERY FOR SLEEP DISORDERS 38
MELATONIN SUPPLEMENTS 38
COGNITIVE BEHAVIORAL THERAPY FOR INSOMNIA 38
HERBAL MEDICINES FOR SLEEP DISORDERS 39
TABLE 3 HERBAL MEDICINES STUDIED FOR INSOMNIA 40
KAVA (PIPER METHYSTICUM) 40
VALERIANA OFFICINALIS 40
PASSIONFLOWER (PASSIFLORA) 40
HOPS (HUMULUS LUPULUS) 41
SOUR DATE (ZIZYPUS JUJUBE) 41
HOMEOPATHIC MEDICINES FOR SLEEP DISORDERS 41
COFFEA 41
GELSEMIUM 42
BELLADONA 42
NUX VOMICA 42
OPIUM 42
AROMATHERAPY FOR SLEEP 42

CHAPTER 6 SLEEP-AID MEDICATION: AN OVERVIEW 46
BENZODIAZEPINE SLEEP AIDS 46
NONBENZODIAZEPINE SLEEP AIDS 46
MELATONIN RECEPTOR AGONISTS (ROZEREM) 47
ANTIDEPRESSANTS AS SLEEP AIDS 47
BRIEF DESCRIPTION OF SOME POPULAR SLEEP MEDICATIONS 48
BUTISOL SODIUM (BUTABARBITAL SODIUM TABLETS) 48
Adverse Reactions with Butisol Sodium 48
DOXEPIN HYDROCHLORIDE 48
Adverse Reactions with Doxepin 49
ESTAZOLAM 49
Adverse Reactions with Estazolam 50
TABLE 4 ADVERSE EVENTS IN CLINICAL TRIALS WITH ESTAZOLAM 50
FLURAZEPAM 51
Adverse Reactions with Flurazepam 51
HALCION (TRIAZOLAM) 51
Adverse Reactions with Halcion 51
TABLE 5 ADVERSE EVENTS IN CLINICAL TRIALS WITH HALCION 52
HORIZANT (GABAPENTIN ENACARBIL) 52
Mechanism of Action 52
Adverse Reactions with Horizant 52
TABLE 6 ADVERSE EVENTS REPORTED IN CLINICAL TRIALS WITH HORIZANT 53
LUNESTA (ESZOPICLONE) 53
Mechanism of Action 53
Adverse Reactions With Lunesta 54
TABLE 7 ADVERSE EVENTS IN CLINICAL TRIALS WITH LUNESTA 54
MELATONIN PYRIDOXINE HCL 55
NUVIGIL (ARMODAFINIL) 55
Mechanism of Action 55
Adverse Reactions with Nuvigil 55
TABLE 8 ADVERSE EVENTS IN CLINICAL TRIALS WITH NUVIGIL 55
PROVIGIL (MODAFINIL) 56
Mechanism of Action 57
Adverse Reactions with Provigil 57
TABLE 9 ADVERSE EVENTS REPORTED IN CLINICAL TRIALS WITH PROVIGIL 57
QUAZEPAM 59
Clinical Study Experience with Quazepam 59
TABLE 10 ADVERSE EVENTS REPORTED IN CLINICAL TRIALS WITH QUAZEPAM 59
RESTORIL (TEMAZEPAM) 59
Adverse Reactions with Restoril 60
TABLE 11 ADVERSE EVENTS WITH RESTORIL IN CLINICAL TRIALS 60
ROZEREM (RAMELTEON) 60
Adverse Reactions with Rozerem 61
TABLE 12 ADVERSE EVENTS REPORTED IN CLINICAL TRIALS WITH ROZEREM 61
SECONAL SODIUM 61
Adverse Effects with Seconal Sodium 61
SOMNOTE (CHLORAL HYDRATE) 62
Adverse Reactions with Somnote 62
SONATA (ZALEPLON) 62
Mechanism of Action 62
Adverse Reactions with Sonata 62
TABLE 13 ADVERSE EVENTS OBSERVED IN CLINICAL TRIALS WITH SONATA 63
XYREM (SODIUM OXYBATE) 64
Mechanism of Action 64
Adverse Reactions with Xyrem 64
TABLE 14 ADVERSE REACTIONS WITH XYREM 64
ZOLPIDEM SL 65
Mechanism of Action 65
Adverse Reactions with Zolpidem SL 65
TABLE 15 ADVERSE EVENTS WITH ZOLPIDEM SL (PERCENTAGE OF PATIENTS
REPORTING) 66
TABLE 16 ADVERSE EVENTS IN LONG-TERM PLACEBO-CONTROLLED CLINICAL
TRIALS (PERCENTAGE OF PATIENTS REPORTING) 66
ZOLPIMIST (ZOLPIDEM TARTARATE) 67
Mechanism of Action 67
Adverse Reactions With Zolpimist 68
TABLE 17 ADVERSE EVENTS WITH ZOLPIMIST FOR TEN NIGHTS (% OF PATIENT
REPORTING) 68
TABLE 18 ADVERSE EVENTS WITH ZOLPIMIST FOR 35 NIGHTS 69

CHAPTER 7 SLEEP-AID DEVICES: AN OVERVIEW 71
POLYSOMNOGRAPHY 71
PSG SYSTEMS: PRODUCT COMPARISONS 71
Easy III PSG 71
SomnoStar 72
Sapphire PSG 72
Grael 72
RemLogic PSG System 72
Comet XL PSG System 72
Natus Sleepworks PSG with XLTEK Connex Amplifier 73
AirPSG 73
Alice 5 73
Brain Wave II PSG (BWII PSG) 73
SOMNOscreen Plus PSG 73
Harmonie-S Sleep System 74
Easy III Amplifier With Easy III Software 74
Easy Ambulatory with Easy III Software 74
SomnoStar Software With z4 Amplifier 74
Sapphire PSG Amplifier with Crystal PSG Software 75
Grael HD-PSG Amplifier with ProFusion PSG 3 Software 75
Somté PSG System With ProFusion PSG 3 Software 75
Sandman Software with S4500/MDrive Amplifier 76
PSG-1100 Sleep System 76
Alice 6 LDxN With Sleepware G3 76
Galaxy PSG Diagnostic Platform With Jupiter Amplifier 77
Sleepvirtual BWIII 77
SOMNOscreen plus PSG with DOMINO Software 77
POSITIVE AIRWAY PRESSURE SYSTEMS (CPAP) 77
CPAP SYSTEMS: PRODUCT COMPARISON 78
IntelliPAP AutoAdjust 78
IntelliPAP AutoBilevel 78
F & P ICON+ Auto 78
F & P ICON+ Premo 78
Z1 CPAP System 79
System One REMstar Auto 79
S9 VPAP Auto 79
Transcend Auto 79
Transcend EZEX 79
The World's Smallest CPAP 80
CPAP ACCESSORIES WITH FAVORABLE REVIEWS 80
SoClean 2 CPAP Sanitizer 80
Control III (CPAP Disinfectant) 80
Hurricane HE 81
Gecko Nasal Pad and Zippered CPAP Tubing Wrap 81
PAPillow 81
SnuggleHose 82
Quartz 82
CPAP Pillow 82
Comfort Products from Pad a Cheek 83
CPAP Hose Lift V5 83
CPAPHolders 83
CPAP Nightstand 83
EZTalk 83
AIRWAY INTERFACES 84
PRODUCT COMPARISON OF INTERFACES 84
Willow Nasal Pillow Systems 84
Miran and Sopora Masks 84
Nonny Pediatric Mask 84
TAP PAP Nasal Pillow Mask 85
Winx Sleep Therapy System Mouthpiece 85
SNAPP 2.0 Direct Nasal Mask 85
SleepWeaver ADVANCE Soft Cloth Nasal CPAP Mask 86
SleepWeaver Anew Soft Cloth Full Face PAP Mask 86
SleepWeaver Elan Soft Cloth Nasal CPAP Mask 86
F & P Pilairo Q 86
6700 Series Disposable V2 Mask 87
QUEST HOMECARE Full Face Mask 87
V2 Full Face CPAP Mask 87
Aloha Nasal Pillow System 87
Hybrid Dual-Airway Mask 88
Nasal-Aire II 88
Amara Full Face Mask 88
Nuance and Nuance Pro Gel Pillows Mask 89
Mirage FX Nasal Mask 89
Quattro Air 89
Swift FX Nasal Mask 89
MiniMe 2 Pediatric Mask 90
HOME SLEEP TESTING DEVICES 90
COMPARISON OF HOME SLEEP TESTING DEVICES 90
ORAL APPLIANCE THERAPY PRODUCTS 95
PRODUCT COMPARISON 96
ACTIGRAPHY 104
PRODUCT COMPARISON 105

CHAPTER 8 SLEEP-AID MARKET SIZE AND GROWTH 114
PRESCRIPTION SLEEP MEDICATIONS 114
TABLE 19 THE BEST-SELLING PRESCRIPTION SLEEPING PILLS 115
TABLE 20 ADVERSE EVENTS WITH ZOLPIDEM 115
EFFECTIVENESS OF NEWER SLEEPING PILLS 116
TABLE 21 EFFECTIVENESS OF AND DIFFERENCES BETWEEN NEWER SLEEPING
PILLS 117
SIDE EFFECTS OF NEWER SLEEPING PILLS 117
TABLE 22 COMMON SIDE EFFECTS OF NEWER SLEEPING PILLS (%) 118
COST OF INSOMNIA DRUGS 118
TABLE 23 COST OF INSOMNIA DRUGS ($) 119
OVER-THE-COUNTER SLEEP MEDICATIONS 119
HERBAL AND NATURAL SLEEP AIDS 120
SLEEP-MEDICATION MARKET SIZE AND FORECAST 120
TABLE 24 GLOBAL MARKET FOR SLEEP-AID MEDICATION, THROUGH 2019 ($
BILLIONS) 121
FIGURE 4 GLOBAL MARKET FOR SLEEP-AID MEDICATION, 2013-2019 ($ BILLIONS) 121
GLOBAL MARKET FOR PRESCRIPTION SLEEP MEDICATIONS 121
TABLE 25 GLOBAL MARKET FOR PRESCRIPTION SLEEP-AID MEDICATION BY
CATEGORY, THROUGH 2019 ($ BILLIONS) 122
FIGURE 5 GLOBAL MARKET FOR PRESCRIPTION SLEEP-AID MEDICATION BY
CATEGORY, 2013-2019 ($ BILLIONS) 122
TABLE 26 NONBENZODIAZEPINES USED IN SLEEP DISORDERS 123
TABLE 27 NARCOLEPSY PRODUCTS 124
TABLE 28 BENZADIAZEPINES FOR INSOMNIA 124
TABLE 29 DRUGS PRESCRIBED FOR RESTLESS LEG SYNDROME 125
TABLE 30 MELATONIN RECEPTOR AGONISTS FOR SLEEP DISORDERS 126
GLOBAL MARKET FOR OTC/HERBAL SUPPLEMENTS 126
TABLE 31 GLOBAL MARKET FOR OTC/HERBAL SUPPLEMENTS FOR SLEEP
DISORDERS, THROUGH 2019 ($ MILLIONS) 126
FIGURE 6 GLOBAL MARKET FOR OTC/HERBAL SUPPLEMENTS FOR SLEEP
DISORDERS, 2013-2019 ($ MILLIONS) 126
OTC Analgesics and Combination Drugs 127
TABLE 32 ANALGESIC AND COMBINATION DRUGS FOR SLEEP 128
OTC Antihistamines for Sleep Disorders 128
TABLE 33 ANTIHISTAMINES FOR SLEEP DISORDERS 128
OTC Natural Sleep Aids 129
TABLE 34 NATURAL SLEEP AIDS 129
GLOBAL MARKET FOR SLEEP-AID MEDICATION BY REGION 132
TABLE 35 GLOBAL MARKET FOR SLEEP-AID MEDICATIONS BY REGION, THROUGH
2019 ($ BILLIONS) 132
FIGURE 7 GLOBAL MARKET FOR SLEEP-AID MEDICATIONS BY REGION, 2013-2019
($ BILLIONS) 133
Prescription Sleep-Drug Use in the U.S. 133
FIGURE 8 PRESCRIPTION SLEEP-AID USE IN THE U.S. (%) 134
Prescription Sleep-Drug Use in the U.S. by Gender and Ethnicity 134
FIGURE 9 PRESCRIPTION SLEEP-AID USE IN THE U.S. BY GENDER AND ETHNICITY
(%) 135
Ratings of Sleep Aids in the U.S. 135
TABLE 36 RATINGS OF SLEEP AIDS IN THE U.S. 136
GLOBAL MARKET FOR SLEEP APNEA 136
FIGURE 10 GLOBAL MARKET FOR SLEEP APNEA DEVICES, 2013-2019 ($ BILLIONS) 137
GLOBAL MARKET FOR SLEEP APNEA BY REGION 137
TABLE 37 GLOBAL MARKET FOR SLEEP APNEA DEVICES BY REGION, THROUGH
2019 ($ BILLIONS) 138
FIGURE 11 GLOBAL MARKET FOR SLEEP APNEA DEVICES BY REGION, 2013-2019 ($
BILLIONS) 138
Global Market for Auto-PAP Devices 139
FIGURE 12 GLOBAL MARKET FOR APAP DEVICES, 2013-2019 ($ MILLIONS) 140
U.S. Market for Sleep Apnea Devices by Product Type 140
FIGURE 13 U.S. MARKET FOR APNEA DEVICES BY PRODUCT TYPE IN UNIT
SHIPMENT, 2013-2019 (NUMBER OF UNITS) 141
U.S. Market for CPAP Devices 141
FIGURE 14 U.S. MARKET FOR CPAP DEVICES IN UNIT SHIPMENT, 2013-2019
(NUMBER OF UNITS) 142
U.S. Market for Bi-Level Devices 143
FIGURE 15 U.S. MARKET FOR BI-LEVEL DEVICES IN UNIT SHIPMENT, 2013-2019 (NO.
OF UNITS) 143
U.S. Market for APAP Devices 144
FIGURE 16 U.S. MARKET FOR APAP DEVICES IN UNIT SHIPMENT, 2013-2019
(NUMBER OF UNITS) 144
MEDICARE SPENDING FOR POLYSOMNOGRAPHY TESTS 144
TABLE 38 POLYSOMNOGRAPHY PROCEDURE PRICING IN THE U.S. ($) 145
FIGURE 17 MEDICARE SPENDING FOR POLYSOMNOGRAPHY TESTS, 2005-2013 ($
MILLIONS) 145
GLOBAL MARKET FOR AMBULATORY/HOME SLEEP-DIAGNOSTIC DEVICES 146
FIGURE 18 GLOBAL MARKET FOR AMBULATORY/HOME SLEEP-DIAGNOSTIC
DEVICES, 2013-2019 ($ MILLIONS) 146
Advantages of Home Sleep Testing 147
Economics of Home Sleep Testing 147
Market Leaders in Home Sleep Testing Devices 148
FIGURE 19 HOME SLEEP TESTING DEVICES' MARKET SHARE BY COMPANY, 2013 (%
SHARE) 148
SLEEP LABORATORIES 148
FIGURE 20 GLOBAL REVENUE FOR SLEEP LABORATORIES, 2013-2019 ($ BILLIONS) 149
TABLE 39 GLOBAL REVENUES FOR SLEEP LABORATORIES BY REGION, THROUGH
2019 ($ BILLIONS) 150
FIGURE 21 GLOBAL REVENUES FOR SLEEP LABORATORIES BY REGION, 2013-2019
($ BILLIONS) 150
NUMBER OF SLEEP CENTERS IN THE U.S. 150
FIGURE 22 GROWTH IN NUMBER OF SLEEP CENTERS IN THE U.S., 1990-2013 151
HOME SLEEP TESTING IN THE U.S. 151
CURRENT OPTIONS IN PORTABLE SLEEP MARKET 152
MATTRESS AND PILLOW 154
TYPES OF MATTRESSES 154
Innerspring Mattresses 154
Memory Foam Mattresses 154
Inflatable Air Mattresses 154
Gel Mattresses 155
PILLOWS 155
Natural Fill Pillow 155
Synthetic Fill Pillow 155
Poly Cluster Fill Pillows 156
Foam Pillows 156
Memory Foam Pillows 156
GLOBAL MARKET FOR MATTRESSES AND PILLOWS 156
FIGURE 23 GLOBAL MARKET FOR MATTRESSES AND PILLOWS, 2013-2019 ($
BILLIONS) 157
TABLE 40 GLOBAL MARKET FOR MATTRESSES AND PILLOWS BY REGION,
THROUGH 2019 ($ BILLIONS) 158
FIGURE 24 GLOBAL MARKET FOR MATTRESSES AND PILLOWS, 2013-2019 ($
BILLIONS) 158
FIGURE 25 GLOBAL MARKET FOR MATTRESSES AND PILLOWS BY REGION, 2019 (%) 159
MATTRESSES: THE LEADING HOUSEHOLD CONSUMABLES 159
FIGURE 26 MATTRESSES IN RELATION TO SOME HOUSEHOLD CONSUMABLES IN
DEVELOPED MARKETS (%) 160
GLOBAL MATTRESS PRODUCTION BY MATERIAL 160
FIGURE 27 BREAKDOWN OF GLOBAL MATTRESS PRODUCTION BY MATERIAL, 2014
(%) 160
PRICE POINT COMPARISONS FOR MATTRESSES 161
TABLE 41 PRICE POINT COMPARISON OF MATTRESSES BY MARKET LEADERS, 2013 162
LEADING MATTRESS AND PILLOW VENDORS IN THE U.S. 162
FIGURE 28 U.S. BEDDING MARKET SHARE BY LEADING VENDORS (%) 163

CHAPTER 9 LATEST DEVELOPMENTS IN SLEEP INDUSTRY 166
SLEEP MEDICATION APPROVED IN 2014 166
HELTIOZ (TASIMELTEON) 166
Clinical Results 166
Side Effects 167
Mechanism of Action 167
SLEEP DISORDER MEDICATIONS IN THE PIPELINE 167
TABLE 42 SELECTED SLEEP DISORDER MOLECULES IN THE PIPELINE 167
SLEEP RESEARCH FUNDING IN THE U.S. 168
TABLE 43 NIH FUNDING FOR SLEEP RESEARCH, 2010-2015 ($ MILLIONS) 168

CHAPTER 10 SLEEP AIDS: MARKET SUMMARY 170
TOTAL MARKET 170
FIGURE 29 GLOBAL MARKET FOR SLEEP AIDS: TECHNOLOGIES AND MARKETS,
2013-2019 ($ BILLIONS) 170
TOTAL MARKET BY PRODUCT TYPE 170
TABLE 44 GLOBAL MARKET FOR SLEEP AIDS BY PRODUCT TYPE, THROUGH 2019 ($
BILLIONS) 171
FIGURE 30 GLOBAL MARKET FOR SLEEP AIDS BY PRODUCT TYPE, 2013-2019 ($
BILLIONS) 172
FIGURE 31 GLOBAL MARKET FOR SLEEP AIDS BY PRODUCT TYPE, 2019 (%) 173
TOTAL SLEEP-AID MARKET BY REGION 174
TABLE 45 GLOBAL MARKET SHARES FOR SLEEP AIDS: TECHNOLOGIES AND
MARKETS BY REGION, 2013-2019 (%) 174
FIGURE 32 GLOBAL MARKET SHARES FOR SLEEP AIDS BY REGION, 2013-2019 (%) 174
INDUSTRY PARTICIPANTS BY PRODUCT TYPE 175
TABLE 46 SELECTED PARTICIPANTS BY PRODUCT TYPE, 2013 176

CHAPTER 11 COMPANY PROFILES 179
3B MEDICAL INC. 179
BRIEF HISTORY 179
PRODUCTS 179
Willow Nasal Pillow Systems 179
iVolve Nasal Mask 180
RESmart BPAP Bi-level Positive Airway Pressure 180
RESmart Auto APAP 180
RESmart CPAP 180
Sleep View Sleep Screener 181
Polymate YH-1000 Polygraph 181
ACTIGRAPH LLC 181
BRIEF HISTORY 182
PRODUCTS 182
wGT3X-BT Monitor 182
wActiSleep-BT Monitor 182
ActiLife 6 182
ADVANCED BRAIN MONITORING INC. 183
BRIEF HISTORY 183
PRODUCTS 183
Sleep Profiler 183
Apnea Guard 183
Night Shift 183
AIRWAY MANAGEMENT INC. 184
BRIEF HISTORY 184
PRODUCTS 184
TAP 3 Elite 184
TAP 3 184
AMBULATORY MONITORING INC. 185
BRIEF HISTORY 185
PRODUCTS 185
Motionlogger Actigraph 185
Inductotrace 185
PVT-192 Psychomotor Vigilance Task Master 186
APNEA SCIENCES CORP. 186
BRIEF HISTORY 186
PRODUCT 186
ApneaRx 186
APNICURE INC. 186
BRIEF HISTORY 187
PRODUCT 187
Winx 187
BLAIREX LABORATORIES INC. 187
BRIEF HISTORY 187
PRODUCT 188
Sleepinal 188
BOEHRINGER INGELHEIM PHARMACEUTICALS INC. 188
BRIEF HISTORY 188
PRODUCTS 188
Mirapexin 188
Sifrol 189
Pexola 189
Mirapex 189
BRAEBON MEDICAL 189
BRIEF HISTORY 189
SELECTED SLEEP PRODUCTS 190
PureFlow Oronasal Cannula & Filter Model 0597 190
PureFlow Duo Oronasal Cannula & Filter Model 0588 190
Nasal & Oral Luer Lock Cannula & Safety Filter Model 0589 190
Large Bore Nasal & Oral Cannula & Filter Model 0587 190
Adjustable and Nasal Luer Lock Cannula & Filter Model 0599 190
ValueFlow Nasal Cannula With Male Luer Lock Model 5582 191
Large Bore Nasal Cannula & Safety Filter Model 0582 191
Model 0582M CO2 191
Model 0582 CO2 191
PureFlow 191
Disposable Airflow 191
MediByte 191
MediByte Junior 192
DentiTrac 192
CADWELL LABORATORIES INC. 192
BRIEF HISTORY 192
SLEEP PRODUCTS 193
Easy III PSG 193
EASY Ambulatory PSG With Q-Video Mobile 193
EASY ApneaTrak 193
CAMNTECH LTD. 193
BRIEF HISTORY 193
PRODUCTS 194
MotionWatch 8 194
PRO-Diary 194
CAREFUSION CORP. 194
BRIEF HISTORY 194
PRODUCTS 195
SomnoStar z4 Sleep System 195
QDC-Pro 195
NOX-T3 Portable Sleep Monitor 195
ApneaRx Sleep Therapy Device 195
Advantage Series Full-Face Mask 196
IQ Nasal Mask 196
MiniMe Nasal Mask 196
Mojo Full-Face Mask 196
SNAPP 2.0 Nasal Interface 197
REVENUE HISTORY 197
TABLE 47 CAREFUSION'S REVENUES, 2010-2013 ($ MILLIONS) 197
CIRCADIANCE LLC 197
BRIEF HISTORY 197
PRODUCTS 198
SleepWeaver Anew 198
SleepWeaver Elan 198
SleepWeaver Advance 198
CLEVELAND MEDICAL DEVICES INC. 198
BRIEF HISTORY 198
PRODUCTS 199
SleepView 199
SleepScout 199
Sapphire PSG 199
COMPUMEDICS LTD. 199
BRIEF HISTORY 200
PRODUCTS 200
Grael-HD 200
Profusion Sleep 4 200
PROFusionDV 201
Somte PSG 201
Siesta 802 PSG 201
REVENUE HISTORY 201
TABLE 48 COMPUMEDIC'S REVENUES, 2010-2013 ($ THOUSANDS) 202
DEVILBISS HEALTHCARE LLC 202
BRIEF HISTORY 202
PRODUCTS 202
DISTAR LLC 205
BRIEF HISTORY 205
PRODUCTS 205
ECR PHARMACEUTICALS 208
BRIEF HISTORY 208
PRODUCT 208
Zolpimist (Zolpidem Tartarate) 208
FISHER & PAYKEL HEALTHCARE CORP. LIMITED 209
BRIEF HISTORY 209
PRODUCTS 209
REVENUE HISTORY 212
TABLE 49 FISHER & PAYKEL'S REVENUES FROM SLEEP APNEA PRODUCTS,
2009-2013 ($ THOUSANDS) 212
GLIDEWELL LABORATORIES 212
BRIEF HISTORY 212
PRODUCTS 213
Silent Nite sl 213
aveoTSD 213
TAP/TAP 3 TL 213
EMA 213
HANS RUDOLPH INC. 214
BRIEF HISTORY 214
PRODUCTS 214
7600 Series V2 CPAP & BiPAP Mask 214
HUMAN DESIGN MEDICAL LLC 214
BRIEF HISTORY 214
PRODUCTS 215
The Z1 215
INNOMED TECHNOLOGIES INC. 215
BRIEF HISTORY 215
PRODUCTS 215
Aspen 215
Aloha Nasal Pillow System 216
Hybrid Universal Interface 216
Nasal-Aire II 216
Nasal-Aire II Petite 216
Bravo CPAP Interface 216
Bravo II Nasal Pillow System 217
Sylent 217
INSPIRE MEDICAL SYSYTEMS INC. 217
BRIEF HISTORY 217
PRODUCT 218
Inspire Upper-Airway Stimulation 218
ITAMAR MEDICAL LIMITED 218
BRIEF HISTORY 218
PRODUCT 219
WatchPAT 219
JOHNSON & JOHNSON 219
BRIEF HISTORY 219
PRODUCT 219
Tylenol PM 219
MODERN DENTAL LABORATORY USA LLC 220
BRIEF HISTORY 220
PRODUCTS 220
Moses Appliance 220
EMA 220
NATUS MEDICAL INCORPORATED 220
BRIEF HISTORY 221
PRODUCTS 221
REVENUE HISTORY 224
TABLE 50 NATUS' REVENUES, 2009-013 ($ THOUSANDS) 224
NIHON KOHDEN AMERICA INC. 224
BRIEF HISTORY 224
PRODUCT 225
PSG-1100A 225
NORTHEAST MONITORING INC. 225
BRIEF HISTORY 225
PRODUCT 225
LX Sleep Software 225
NOVASOM INC. 226
BRIEF HISTORY 226
PRODUCTS 226
NovaSom QSG 226
AccuSom 227
NOX MEDICAL 227
BRIEF HISTORY 227
PRODUCTS 227
Nox T3 Sleep Monitor 227
Nox A1 PSG System 228
PFIZER INC. 228
BRIEF HISTORY 228
PRODUCTS 228
Advil PM 228
Zaleplon 229
REVENUE HISTORY 229
TABLE 51 COMPANY REVENUES, 2011-2013 ($ MILLIONS) 229
RESMED INC. 229
BRIEF HISTORY 229
PRODUCTS 230
S9 Sleep Therapy System 230
AutoSet CS-A 230
VPAP ST 231
VPAP ST with iVAPS 231
VPAP ST-A with iVAPS 231
S9 AutoSet 232
S9 Escape Auto 232
S9 Elite 232
Stellar 150 232
Stellar 100 232
AutoSet CS 2 232
VPAP Tx 233
Elisee 150 233
Elisee 350 233
VS III 234
H5i 234
H4i 234
ApneaLink Plus 234
ApneaLink 234
OTHER PRODUCTS FROM RESMED 235
RESMED'S MARKETS 235
REVENUE HISTORY 236
TABLE 52 RESMED'S REVENUES, 2009-2013 ($ THOUSANDS) 236
RESPIRONICS INC. 236
BRIEF HISTORY 237
PRODUCTS 237
System One Sleep Therapy Systems 237
BiPAP autoSV Advanced-System One 237
SleepMapper 238
Wisp Nasal Mask System 238
TrueBlue Nasal Mask 238
ComfortGel Nasal Mask 239
EasyLife Nasal Mask 239
ComfortClassic Nasal Mask 239
Profile Lite Nasal Mask 239
Naunce and Naunce Pro Pillow Masks 240
GoLife Pillow Masks for Men and Women 240
OptiLife Pillow Mask 240
Amara Full-Face Mask 240
ComfortGel Full Face Mask 240
FitLife Full-Face Mask 241
Total Face Mask 241
Alice 6 LDE Diagnostic System 241
Alice 6 LDx Diagnostic System 241
Alice PDx Portable Sleep-Diagnostic System 242
Stardust II Sleep Recorder 242
OmniLab Advanced Titration System 242
RUSleeping RTS Screener 242
Actiwatch Spectrum Plus 243
Actiwatch Spectrum PRO 243
REVENUE HISTORY 243
TABLE 53 PHILIPS' HEALTHCARE REVENUES, 2010-2013 (EUR MILLIONS) 244
SANOFI 244
BRIEF HISTORY 244
PRODUCTS 244
Zolpidem 244
REVENUE HISTORY 244
TABLE 54 SANOFI'S REVENUES, 2008-2013 (EUR MILLIONS) 244
SELECT COMFORT CORP. 245
BRIEF HISTORY 245
PRODUCTS 245
REVENUE HISTORY 249
TABLE 55 SELECT COMFORT CORP.'S REVENUES, 2008-2013 ($ MILLIONS) 249
SERTA INC. 249
BRIEF HISTORY 250
PRODUCTS 250
SIMMONS BEDDING COMPANY 253
BRIEF HISTORY 253
PRODUCTS 253
Simmons CURV 253
Simmons BeautySleep 253
SLEEPMED INC. 253
BRIEF HISTORY 254
SOMNETICS INTERNATIONAL INC. 254
BRIEF HISTORY 254
PRODUCTS 254
SLEEPVIRTUAL 255
BRIEF HISTORY 255
PRODUCTS 255
SOMAXON PHARMACEUTICALS 256
BRIEF HISTORY 256
PRODUCT 256
SOMNOMED LIMITED 256
BRIEF HISTORY 257
PRODUCTS 257
SOMNOMEDICS LLC 257
BRIEF HISTORY 257
PRODUCTS 258
STRONG DENTAL 258
BRIEF HISTORY 258
PRODUCTS 259
SUAD Device 259
The Morning Repositioner 259
TSA 259
SUNOVION PHARMACEUTICALS INC. 259
BRIEF HISTORY 259
PRODUCT 260
Lunesta 260
TABLE 56 U.S. SALES OF LUNESTA, 2011-2013 ($ THOUSANDS, UNITS IN
THOUSANDS) 260
SYNTHON BV 260
BRIEF HISTORY 260
TAKEDA PHARMACEUTICAL COMPANY LIMITED 261
BRIEF HISTORY 261
PRODUCT 261
Rozerem 261
REVENUE HISTORY 261
TABLE 57 TAKEDA'S REVENUES, 2009-2013 (JPY MILLIONS) 262
TEMPUR SEALY INTERNATIONAL INC. 262
BRIEF HISTORY 262
PRODUCTS 262
Tempur-Pedic 262
Tempur 262
Sealy Posturepedic 263
Sealy Optimum 263
REVENUE HISTORY 263
TABLE 58 TEMPUR SEALY'S REVENUES, 2009-2013 ($ MILLIONS) 263
TEVA PHARMACEUTICAL INDUSTRIES LIMITED 264
BRIEF HISTORY 264
PRODUCTS 264
Provigil (Modafinil) 264
Nuvigil (Armodafinil) 264
TABLE 59 U.S. RETAIL SALES OF PROVIGIL, 2011 THROUGH FIRST QUARTER OF
2012 ($ THOUSANDS, THOUSANDS OF UNITS) 265
VANDA PHARMACEUTICALS INC. 265
BRIEF HISTORY 265
PRODUCT 265
Heltioz (Tasimelteon) 265
XENOPORT INC. 266
BRIEF HISTORY 266
PRODUCT 266
Horizant (Gabapentin Encarbil) 266
MARKET SHARES FOR SLEEP AIDS BY REGION, 2013-2019 (%) 174