Reportlinker Adds Japanese Market for Interventional Cardiology 2010

NEW YORK, May 12 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Japanese Market for Interventional Cardiology 2010

http://www.reportlinker.com/p0192992/Japanese-Market-for-Interventional-Cardiology-2010.html

In 2009, the Japanese market for interventional cardiology devices was valued at nearly

$1.2 billion.

The Japanese market for interventional cardiology devices includes the markets for:

-Coronary stents,

-Percutaneous transluminal coronary angioplasty (PTCA) balloon catheters,

-Interventional catheters,

-Interventional guidewires,

-Introducer sheaths,

-Embolic protection devices (EPD),

-Atherectomy devices,

-Thrombectomy devices,

-Diagnostic catheters,

-Intravascular ultrasound (IVUS) catheters

-Optical coherence tomography (OCT) catheters

Japan has one of the oldest populations in the world, and demographic pressure is increasing the demand for healthcare. As a result, the Japanese government is attempting to reduce costs by decreasing reimbursement rates, thus putting downward pressure on prices and limiting growth of the market for interventional cardiology devices. Meanwhile, the high use of intravascular imaging in Japan makes the country a model for how global interventional cardiology markets may respond to the increasing utilization of IVUS and OCT.

Within the Japanese interventional cardiology device market, companies such as Abbott Laboratories, Asahi Intecc, Boston Scientific, Cordis, Medtronic and Terumo lead the market. This report provides a comprehensive and detailed analysis of market revenues by device type, market forecasts through 2016, unit sales, average selling prices, market drivers and limiters and a detailed competitive analysis, including manufacturer market shares and product portfolios.

Japanese Market for

TABLE OF CONTENTS ...I

LIST OF FIGURES ......VIII

LIST OF CHARTS .......XIII

EXECUTIVE SUMMARY .... 1

1.1 JAPANESE MARKET FOR INTERVENTIONAL CARDIOLOGY DEVICES ....... 1

1.2 BARE-METAL AND DRUG-ELUTING STENTS ...... 2

1.3 PTCA BALLOON CATHETERS 3

1.4 INTERVENTIONAL CATHETERS ...... 3

1.5 INTERVENTIONAL GUIDEWIRES ..... 4

1.6 INTRODUCER SHEATHS .. 5

1.7 EMBOLIC PROTECTION DEVICES ... 5

1.8 ATHERECTOMY DEVICES ....... 6

1.9 THROMBECTOMY DEVICES .... 6

1.10 DIAGNOSTIC CATHETERS ..... 7

1.11 IVUS CATHETERS ... 8

1.12 OCT CATHETERS .... 9

1.13 VULNERABLE PLAQUE DEVICES 10

1.14 PFO, ASD AND VSD DEVICES .. 10

1.15 PERCUTANEOUS MITRAL VALVE REPAIR DEVICES 10

1.16 AORTIC HEART VALVE REPLACEMENT DEVICES ... 10

1.17 COMPETITIVE ANALYSIS ... 11

RESEARCH METHODOLOGY 12

2.1 RESEARCH SCOPE ... 12

2.2 IDATA'S 9-STEP METHODOLOGY 12

Step 1: Project Initiation & Team Selection ..... 13

Step 2: Prepare Data Systems and Perform Secondary Research . 14

Step 3: Preparation for Interviews & Questionnaire Design 15

Table of Contents

© iData Research Inc., 2010 www.idataresearch.net ii

Step 4: Performing Primary Research ...... 16

Step 5: Research Analysis: Establishing Baseline Estimates 18

Step 6: Market Forecast and Analysis ...... 18

Step 7: Identify Strategic Opportunities ... 20

Step 8: Final Review and Market Release 21

Step 9: Customer Feedback and Market Monitoring 22

JAPANESE MARKET FOR INTERVENTIONAL CARDIOLOGY DEVICES

OVERVIEW .... 23

3.1 INTRODUCTION ....... 23

3.2 EXCHANGE RATES .. 24

3.3 JAPANESE MEDICAL DEVICE REGULATORY ENVIRONMENT . 25

3.4 OVERVIEW OF THE MARKET 26

3.5 TREND ANALYSIS BY MARKET SEGMENT 34

3.6 POTENTIAL MARKETS .. 38

3.7 MARKET DRIVERS AND LIMITERS .... 39

3.7.1 Drivers ...... 39

3.7.2 Limiters ..... 39

3.8 COMPETITIVE ANALYSIS ..... 41

3.9 MERGERS AND ACQUISITIONS ..... 45

BARE-METAL AND DRUG-ELUTING STENTS ....... 48

4.1 INTRODUCTION ....... 48

4.2 PROCEDURE NUMBERS 51

4.3 MARKET ANALYSIS AND FORECAST 53

4.4 BARE-METAL STENT MARKET .... 56

4.4.1 Market Analysis and Forecast .... 56

4.4.2 Market Drivers and Limiters . 60

4.4.2.1 Drivers .60

4.4.2.2 Limiters 61

4.4.3 Competitive Analysis ...... 62

4.5 DRUG-ELUTING STENT MARKET . 65

4.5.1 Market Analysis and Forecast .... 65

4.5.2 Market Drivers and Limiters . 70

4.5.2.1 Drivers .70

4.5.2.2 Limiters 70

4.5.3 Competitive Analysis ...... 72

4.5.4 Potential New Market Participants .... 75

4.6 BIOABSORBABLE STENTS .... 76

4.7 BIFURCATED STENTS ... 79

PTCA BALLOON CATHETERS ....... 82

5.1 INTRODUCTION ....... 82

5.2 MARKET ANALYSIS AND FORECAST 84

5.3 MARKET DRIVERS AND LIMITERS .... 87

5.3.1 Drivers ...... 87

5.3.2 Limiters ..... 87

5.4 COMPETITIVE ANALYSIS ..... 88

INTERVENTIONAL CATHETERS .. 91

6.1 INTRODUCTION ....... 91

6.2 MARKET ANALYSIS AND FORECAST 92

6.3 MARKET DRIVERS AND LIMITERS .... 96

6.3.1 Drivers ...... 96

6.3.2 Limiters ..... 96

6.4 COMPETITIVE ANALYSIS ..... 97

INTERVENTIONAL GUIDEWIRES ... 100

7.1 INTRODUCTION ..... 100

7.1.1 Material and Fabrication .... 100

7.2 MARKET ANALYSIS AND FORECAST ...... 101

7.2.1 Conventional Guidewire Market ....... 104

7.2.2 Specialized Guidewire Market .. 107

7.3 MARKET DRIVERS AND LIMITERS .. 110

7.3.1 Drivers .... 110

7.3.2 Limiters ... 110

7.4 COMPETITIVE ANALYSIS ... 111

EMBOLIC PROTECTION DEVICES . 113

8.1 INTRODUCTION ..... 113

8.1.1 Protection Mechanisms 113

8.2 MARKET ANALYSIS AND FORECAST ...... 115

8.3 MARKET DRIVERS AND LIMITERS .. 119

8.3.1 Drivers .... 119

8.3.2 Limiters ... 119

8.4 COMPETITIVE ANALYSIS ... 120

CORONARY ATHERECTOMY DEVICES 121

9.1 INTRODUCTION ..... 121

9.1.1 Technologies ... 121

9.1.1.1 Mechanical 121

9.1.1.2 Laser ..122

9.1.1.3 Directional Coronary Atherectomy (DCA) ..122

9.2 MARKET ANALYSIS & FORECAST .. 123

9.3 MARKET DRIVERS AND LIMITERS .. 127

9.3.1 Drivers .... 127

9.3.2 Limiters ... 127

9.4 COMPETITIVE ANALYSIS ... 128

CORONARY THROMBECTOMY DEVICES .... 131

10.1 INTRODUCTION ... 131

10.1.1 Thrombosis and Drug-Eluting Stents ...... 131

10.1.2 Thrombosis in Japanese Patients .... 132

10.2 MARKET ANALYSIS AND FORECAST .... 133

10.3 MARKET DRIVERS AND LIMITERS 136

10.3.1 Drivers .. 136

10.3.2 Limiters . 136

10.4 COMPETITIVE ANALYSIS . 137

CORONARY INTRODUCER SHEATHS .... 139

11.1 INTRODUCTION ... 139

11.2 MARKET ANALYSIS AND FORECAST .... 140

11.2.1 Introducer Sheaths by Application .. 143

11.3 MARKET DRIVERS AND LIMITERS 145

11.3.1 Drivers .. 145

11.3.2 Limiters . 145

11.4 COMPETITIVE ANALYSIS . 146

CORONARY DIAGNOSTIC CATHETERS ....... 148

12.1 INTRODUCTION ... 148

12.2 MARKET ANALYSIS AND FORECAST .... 149

12.3 MARKET DRIVERS AND LIMITERS 153

12.3.1 Drivers .. 153

12.3.2 Limiters . 153

12.4 COMPETITIVE ANALYSIS . 154

INTRAVASCULAR ULTRASOUND (IVUS) CATHETERS . 157

13.1 INTRODUCTION ... 157

13.1.1 Pre-Stenting Applications .. 157

13.1.2 Post-Stenting Applications . 158

13.1.3 IVUS Console Penetration . 158

13.2 MARKET ANALYSIS AND FORECAST .... 160

13.3 MARKET DRIVERS AND LIMITERS 166

13.3.1 Drivers .. 166

13.3.2 Limiters . 167

13.4 COMPETITIVE ANALYSIS . 168

OPTICAL COHERENCE TOMOGRAPHY (OCT) CATHETERS ....... 171

14.1 INTRODUCTION ... 171

14.1.1 Potential Markets ....... 172

14.1.2 OCT Console Penetration .. 173

14.2 MARKET ANALYSIS AND FORECAST .... 175

14.2.1 OCT Catheter Market 175

14.3 MARKET DRIVERS AND LIMITERS 181

14.3.1 Drivers .. 181

14.3.2 Limiters . 182

14.4 COMPETITIVE ANALYSIS . 183

VULNERABLE PLAQUE DEVICES ... 186

15.1 INTRODUCTION ... 186

15.1.1 Vulnerable Plaque Screening Technologies ... 187

15.1.2 Potential Vulnerable Plaque Treatments 189

15.2 TARGET POPULATION ...... 190

15.3 MARKET ANALYSIS AND FORECAST .... 193

15.3.1 Total Market Potential ....... 193

15.3.2 Potential Screening Market .... 196

15.3.3 Potential Treatment Market .... 197

15.4 COMPETITIVE ANALYSIS . 198

15.4.1 Potential Competitors 198

TRANSCATHETER CONGENITAL HEART DEFECT CLOSURE DEVICES...... 201

16.1 INTRODUCTION ... 201

16.1.1 Patent Foramen Ovale (PFO) 201

16.1.2 Atrial Septal Defect (ASD) . 202

16.1.3 Ventricular Septal Defect (VSD) ..... 202

16.2 MARKET ANALYSIS AND FORECAST .... 203

16.2.1 PFO Target Population ..... 203

16.2.2 ASD and VSD Devices ....... 204

16.2.2.1 ASD and VSD Device Target Population ..204

16.2.2.2 ASD Market ..207

16.2.2.3 VSD Market ..210

16.3 MARKET DRIVERS AND LIMITERS 211

16.3.1 Drivers .. 211

16.3.1.1 PFO Devices .211

16.3.1.2 ASD and VSD Devices ..211

16.3.2 Limiters . 212

16.3.2.1 PFO Devices .212

16.3.2.2 ASD and VSD Devices ..212

16.4 COMPETITIVE ANALYSIS . 214

16.4.1 ASD Devices Market .. 214

16.4.2 VSD Devices Market .. 214

16.4.3 PFO Devices Market . 214

PERCUTANEOUS HEART VALVE DEVICES . 215

17.1 INTRODUCTION ... 215

17.1.1 Percutaneous Mitral Valve Repair (PMVR) ... 215

17.1.2 Percutaneous Aortic Valve Replacement (PAVR) .. 216

17.2 MARKET ANALYSIS AND FORECAST .... 217

17.2.1 Percutaneous Aortic Valve Replacement (PAVR) .. 217

17.2.1.1 Aortic Valve Replacement Procedures ......217

17.2.1.2 Potential Market ...218

17.2.2 Percutaneous Mitral Valve Repair (PMVR) ... 221

17.2.2.1 Mitral Valve Repair Target Population .....221

17.2.2.2 Potential Market ...222

17.3 MARKET DRIVERS AND LIMITERS 225

17.3.1 Drivers .. 225

17.3.1.1 PAVR .......225

17.3.1.2 PMVR .......226

17.3.2 Limiters . 226

17.3.2.1 PAVR .......226

17.3.2.2 PMVR .......227

17.4 COMPETITIVE ANALYSIS . 229

17.4.1 PAVR Market 229

17.4.2 PMVR Market .... 230

ABBREVIATIONS 231

LIST OF FIGURES

EXECUTIVE SUMMARY ..... 1

RESEARCH METHODOLOGY 12

JAPANESE MARKET FOR INTERVENTIONAL CARDIOLOGY DEVICES

OVERVIEW ... 23

Figure 3-1: Interventional Cardiology Devices Market by Segment, Japan,

2006 – 2016 (US$) (Part 1 of 2) ... 28

Figure 3-2: Interventional Cardiology Devices Market by Segment, Japan,

2006 – 2016 (Yen) (Part 1 of 2) 30

Figure 3-3: Trend Analysis by Market Segment, Interventional Cardiology

Devices Market, Japan, 2006 – 2016 (Part 1 of 2) 35

Figure 3-4: Drivers and Limiters, Interventional Cardiology Devices Market,

Japan, 2009 .... 40

Figure 3-5: Leading Competitors, Interventional Cardiology Devices Market,

Japan, 2009 (Part 1 of 2) . 42

BARE-METAL AND DRUG-ELUTING STENTS .... 48

Figure 4-1: Angiography and Angioplasty Procedures, Japan, 2006 – 2016 .. 51

Figure 4-2: Coronary Stent Market by Type, Japan, 2006 – 2016 (US$) ....... 53

Figure 4-3: Coronary Stent Market by Type, 2006 – 2016 (Yen) . 54

Figure 4-4: Bare-Metal Stent Market, Japan, 2006 – 2016 (US$) .... 57

Figure 4-5: Bare-Metal Stent Market, Japan, 2006 – 2016 (Yen) . 57

Figure 4-6: Bare-Metal Stent Penetration Rate, Japan, 2006 – 2016 59

Figure 4-7: Drivers and Limiters, Bare-Metal Stent Market, Japan, 2009 ..... 61

Figure 4-8: Leading Competitors, Bare-Metal Stent Market, Japan, 2009 ..... 63

Figure 4-9: Drug-Eluting Stent Market, Japan, 2006 – 2016 (US$) . 66

Figure 4-10: Drug-Eluting Stent Market, Japan, 2006 – 2016 (Yen) .... 67

Figure 4-11: Drug-Eluting Stent Penetration Rate, Japan, 2006 – 2016 69

Figure 4-12: Drivers and Limiters, Drug-Eluting Stent Market, Japan, 2009 71

Figure 4-13: Leading Competitors, Drug-Eluting Stent Market, Japan, 2009 73

Figure 4-14: Potential Market for Bioabsorbable Stents, Japan, 2014 – 2016

(US$) 77

Figure 4-15: Potential Market for Bioabsorbable Stents, Japan, 2014 – 2016 (Yen) .. 77

Figure 4-16: Potential Market for Bifurcated Stents, Japan, 2012 – 2016 (US$) ... 80

Figure 4-17: Potential Market for Bifurcated Stents, Japan, 2012 – 2016 (Yen) 80

PTCA BALLOON CATHETERS ...... 82

Figure 5-1: PTCA Balloon Catheter Market, Japan, 2006 – 2016 (US$) ....... 84

Figure 5-2: PTCA Balloon Catheter Market, Japan, 2006 – 2016 (Yen) .... 85

Figure 5-3: Units Sold, PTCA Balloon Catheter Market, Japan, 2006 – 2016 ....... 85

Figure 5-4: Drivers and Limiters, PTCA Balloon Catheter Market, Japan, 2009 ... 87

Figure 5-5: Leading Competitors, PTCA Balloon Catheter Market, Japan, 2009... 89

INTERVENTIONAL CATHETERS .. 91

Figure 6-1: Interventional Catheter Market, Japan, 2006 – 2016 (US$) 93

Figure 6-2: Interventional Catheter Market, Japan, 2006 – 2016 (Yen) 93

Figure 6-3: Units Sold, Interventional Catheter Market, Japan, 2006 – 2016 94

Figure 6-4: Drivers and Limiters, Interventional Catheter Market, Japan, 2009 .... 96

Figure 6-5: Leading Competitors, Interventional Catheter Market, Japan, 2009.... 98

INTERVENTIONAL GUIDEWIRES ...... 100

Figure 7-1: Interventional Guidewire Market by Device Type, Japan, 2006 – 2016

(US$) ...... 101

Figure 7-2: Interventional Guidewire Market by Device Type, Japan,

2006 – 2016 (Yen) .... 102

Figure 7-3: Units Sold, Interventional Guidewire Market, Japan, 2006 – 2016 ... 102

Figure 7-4: Conventional Interventional Guidewire Market, Japan, 2006 – 2016

(US$) ...... 104

Figure 7-5: Conventional Interventional Guidewire Market, Japan, 2006 – 2016

(Yen) ... 105

Figure 7-6: Specialized Interventional Guidewire Market, Japan, 2006 – 2016

(US$) ...... 107

Figure 7-7: Specialized Interventional Guidewire Market, Japan, 2006 – 2016

(Yen) ... 108

Figure 7-8: Drivers and Limiters, Interventional Guidewire Market, Japan,

2009 110

Figure 7-9: Leading Competitors, Interventional Guidewire Market, Japan,

2009 111

EMBOLIC PROTECTION DEVICES ..... 113

Figure 8-1: Embolic Protection Devices Market, Japan, 2006 – 2016 (US$)....... 116

Figure 8-2: Embolic Protection Devices Market, Japan, 2006 – 2016 (Yen) ... 116

Figure 8-3: Units Sold, Embolic Protection Devices Market, Japan,

2006 – 2016 .. 117

Figure 8-4: Drivers and Limiters, Embolic Protection Devices Market, Japan,

2009 119

Figure 8-5: Leading Competitors, Embolic Protection Devices Market, Japan,

2009 120

CORONARY ATHERECTOMY DEVICES ..... 121

Figure 9-1: Coronary Atherectomy Devices Market, Japan, 2006 – 2016 (US$) . 124

Figure 9-2: Coronary Atherectomy Devices Market, Japan, 2006 – 2016 (Yen) ...... 124

Figure 9-3: Penetration Rate, Coronary Atherectomy Devices Market, Japan,

2006 – 2016 .. 126

Figure 9-4: Drivers and Limiters, Coronary Atherectomy Devices Market, Japan,

2009 128

Figure 9-5: Leading Competitors, Coronary Atherectomy Devices Market, Japan,

2009 129

CORONARY THROMBECTOMY DEVICES . 131

Figure 10-1: Thrombectomy Devices Market, Japan, 2006 – 2016 (US$) ... 133

Figure 10-2: Thrombectomy Devices Market, Japan, 2006 – 2016 (Yen) 134

Figure 10-3: Penetration Rate, Coronary Thrombectomy Devices Market, Japan,

2006 – 2016 .. 134

Figure 10-4: Drivers and Limiters, Thrombectomy Devices Market, Japan,

2009 136

Figure 10-5: Leading Competitors, Thrombectomy Devices Market, Japan,

2009 137

CORONARY INTRODUCER SHEATHS 139

Figure 11-1: Introducer Sheath Market, Japan, 2006 – 2016 (US$) .... 140

Figure 11-2: Introducer Sheath Market, Japan, 2006 – 2016 (Yen) .... 141

Figure 11-3: Penetration Rate, Introducer Sheath Market, Japan, 2006 – 2016 ... 141

Figure 11-4: Introducer Sheaths by Application, Japan, 2006 – 2009 . 143

Figure 11-5: Drivers and Limiters, Introducer Sheath Market, Japan, 2009 145

Figure 11-6: Leading Competitors, Coronary Introducer Sheath Market, Japan,

2009 146

CORONARY DIAGNOSTIC CATHETERS .... 148

Figure 12-1: Coronary Diagnostic Catheter Market, Japan, 2006 – 2016 (US$) .. 150

Figure 12-2: Coronary Diagnostic Catheter Market, Japan, 2006 – 2016 (Yen)....... 150

Figure 12-3: Units Sold, Coronary Diagnostic Catheter Market, Japan,

2006 – 2016 .. 151

Figure 12-4: Drivers and Limiters, Coronary Diagnostic Catheter Market, Japan,

2009 154

Figure 12-5: Leading Competitors, Coronary Diagnostic Catheter Market, Japan,

2009 155

INTRAVASCULAR ULTRASOUND (IVUS) CATHETERS 157

Figure 13-1: IVUS Console Penetration, Japan, 2006 – 2016 159

Figure 13-2: IVUS Catheter Market, Japan, 2006 – 2016 (US$) .... 161

Figure 13-3: IVUS Catheter Market, Japan, 2006 – 2016 (Yen) 162

Figure 13-4: Penetration Rate, IVUS Catheter Market, Japan, 2006 – 2016 164

Figure 13-5: Penetration Rates, Intravascular Imaging, Japan, 2006 – 2016 ....... 164

Figure 13-6: Drivers and Limiters, IVUS Catheter Market, Japan, 2009 ..... 167

Figure 13-7: Leading Competitors, IVUS Catheter Market, Japan, 2009 .... 169

OPTICAL COHERENCE TOMOGRAPHY (OCT) CATHETERS . 171

Figure 14-1: Penetration Rate, OCT Consoles, Japan, 2006 – 2016 .... 174

Figure 14-2: OCT Catheter Market, Japan, 2006 – 2016 (US$) ..... 176

Figure 14-3: OCT Catheter Market, Japan, 2006 – 2016 (Yen) .. 177

Figure 14-4: Penetration Rate, OCT Catheter Market, Japan, 2006 – 2016 . 179

Figure 14-5: Penetration Rates, Intravascular Imaging, Japan, 2006 – 2016 ....... 179

Figure 14-6: Drivers and Limiters, OCT Catheter Market, Japan, 2009 ...... 183

Figure 14-7: Leading Competitors, OCT Catheter Market, Japan, 2009 ...... 184

VULNERABLE PLAQUE DEVICES ...... 186

Figure 15-1: Target Population, Potential Market for Vulnerable Plaque

Screening, Japan 2006 – 2016 .... 191

Figure 15-2: Maximum Potential Market for Vulnerable Plaque, Japan,

2010 – 2015 (US$M) .... 194

Figure 15-3: Maximum Potential Market for Vulnerable Plaque, Japan,

2010 – 2015 (Yen M) . 194

Figure 15-4: Potential Competitors, Vulnerable Plaque Devices Market, Japan,

2009 200

TRANSCATHETER CONGENITAL HEART DEFECT CLOSURE DEVICES... 201

Figure 16-1: Potential PFO Patient Population, Japan, 2006 – 2016 ... 204

Figure 16-2: Potential ASD and VSD Patient Populations, Japan, 2006 – 2016 .. 206

Figure 16-3: ASD Closure Device Market, Japan, 2006 – 2016 (US$) 208

Figure 16-4: ASD Closure Device Market, Japan, 2006 – 2016 (Yen) .... 208

Figure 16-5: Potential VSD Closure Device Market, Japan, 2012 – 2016

(US$) ...... 210

Figure 16-6: Potential VSD Closure Device Market, Japan, 2012 – 2016 (Yen) ...... 210

Figure 16-7: Drivers and Limiters, PFO Closure Devices Market, Japan, 2009... 213

Figure 16-8: Drivers and Limiters, ASD and VSD Closure Devices Market,

Japan, 2009 .. 213

Figure 16-9: Leading Competitors, ASD Closure Devices Market, Japan, 2009.. 214

PERCUTANEOUS HEART VALVE DEVICES ...... 215

Figure 17-1: Aortic Valve Replacement Procedures, Japan, 2006 – 2016 ... 218

Figure 17-2: Aortic Valve Replacement Device Market, Japan, 2006 – 2016

(US$) ...... 219

Figure 17-3: Aortic Valve Replacement Device Market, Japan, 2006 – 2016

(Yen) ... 219

Figure 17-4: Mitral Valve Repair Procedures, Japan, 2006 – 2016 222

Figure 17-5: Mitral Valve Repair Device Market, Japan, 2006 – 2016 (US$) ..... 223

Figure 17-6: Mitral Valve Repair Device Market, Japan, 2006 – 2016 (Yen) .. 223

Figure 17-7: Drivers and Limiters, PAVR Market, Japan, 2009 .... 228

Figure 17-8: Drivers and Limiters, PMVR Market, Japan, 2009 .... 228

Figure 17-9: Leading Competitors, PAVR Devices Market, Japan, 2009 .... 230

ABBREVIATIONS ... 231

LIST OF CHART S

EXECUTIVE SUMMARY ..... 1

Chart 1-1: Interventional Cardiology Market, Japan, 2006 – 2016 (US$) ....... 1

Chart 1-2: Coronary Stent Market, Japan, 2006 – 2016 (US$) .. 2

Chart 1-3: Units Sold, Interventional Catheter Market, Japan, 2006 – 2016 ... 3

Chart 1-4: Specialized Guidewire Penetration Rate, Japan, 2016 ...... 4

Chart 1-5: Coronary Introducer Sheath Market, Japan, 2006 – 2016 . 5

Chart 1-6: Average Selling Price, Atherectomy Device Market, Japan,

2006 – 2016 (US$) .... 6

Chart 1-7: Units Sold, Coronary Diagnostic Catheter Market, Japan, 2006 – 2016 . 7

Chart 1-8: Intravascular Imaging Penetration Rate, Japan, 2006 – 2016 . 8

Chart 1-9: OCT Catheter Market, Japan, 2006 – 2016 . 9

Chart 1-10: Leading Competitors, Interventional Cardiology Market, Japan,

2009 .. 11

RESEARCH METHODOLOGY 12

JAPANESE MARKET FOR INTERVENTIONAL CARDIOLOGY DEVICES

OVERVIEW ... 23

Chart 3-1: Exchange Rate Between the U.S. Dollar (US$) and the Japanese Yen

(Yen), 2009 ... 24

Chart 3-2: Interventional Cardiology Devices Market, Japan, 2006 – 2016 (US$) 27

Chart 3-3: Interventional Cardiology Devices Market by Segment, Japan, 2009 ... 32

Chart 3-4: Interventional Cardiology Devices Market by Segment, Japan, 2016 ... 33

Chart 3-5: Trend Analysis by Market Segment, Interventional Cardiology

Devices Market, Japan, 2006 – 2016 .... 37

Chart 3-6: Leading Competitors, Interventional Cardiology Devices Market,

Japan, 2009 .... 44

BARE-METAL AND DRUG-ELUTING STENTS .... 48

Chart 4-1: Angiography and Angioplasty Procedures, Japan, 2006 – 2016 ... 52

Chart 4-2: Coronary Stent Market by Type, Japan, 2006 – 2016 (US$) 55

Chart 4-3: Bare-Metal Stent Market, Japan, 2006 – 2016 (US$) ...... 58

Chart 4-4: Bare-Metal Stent Penetration Rate, Japan, 2006 – 2016 . 59

Chart 4-5: Leading Competitors, Bare-Metal Stent Market, Japan, 2009 ...... 64

Chart 4-6: Drug-Eluting Stent Market, Japan, 2006 – 2016 (US$) ... 68

Chart 4-7: Drug-Eluting Stent Penetration Rate, Japan, 2006 – 2016 ... 69

Chart 4-8: Leading Competitors, Drug-Eluting Stent Market, Japan, 2009 ... 74

Chart 4-9: Penetration Rate of Bioabsorbable Stents in the DES Market, Japan,

2006 – 2016 .... 78

Chart 4-10: Penetration Rate of Bifurcated Stents, Japan, 2006 – 2016 81

PTCA BALLOON CATHETERS ...... 82

Chart 5-1: PTCA Balloon Catheter Market, 2006 – 2016 (US$) ...... 86

Chart 5-2: Leading Competitors, PTCA Balloon Catheter Market, Japan, 2009 .... 90

INTERVENTIONAL CATHETERS .. 91

Chart 6-1: Interventional Catheter Market, Japan, 2006 – 2016 (US$) . 95

Chart 6-2: Leading Competitors, Interventional Catheter Market, Japan, 2009 ..... 99

INTERVENTIONAL GUIDEWIRES ...... 100

Chart 7-1: Interventional Guidewire Market by Device Type, Japan, 2006 – 2016

(US$) ...... 103

Chart 7-2: Conventional Guidewire Penetration Rate, Japan, 2006 – 2016 . 105

Chart 7-3: Conventional Interventional Guidewire Market, Japan, 2006 – 2016

(US$) ...... 106

Chart 7-4: Specialized Guidewire Penetration Rate, Japan, 2006 – 2016 .... 108

Chart 7-5: Specialized Interventional Guidewire Market, Japan, 2006 – 2016

(US$) ...... 109

Chart 7-6: Leading Competitors, Interventional Guidewire Market, Japan,

2009 112

EMBOLIC PROTECTION DEVICES ..... 113

Chart 8-1: Embolic Protection Devices Market, Japan, 2006 – 2016 (US$) 118

CORONARY ATHERECTOMY DEVICES ..... 121

Chart 9-1: Coronary Atherectomy Devices Market, Japan, 2006 – 2016 (US$) ... 125

Chart 9-2: Leading Competitors, Coronary Atherectomy Devices Market, Japan,

2009 130

CORONARY THROMBECTOMY DEVICES . 131

Chart 10-1: Thrombectomy Devices Market, Japan, 2006 – 2016 (US$) ..... 135

Chart 10-2: Leading Competitors, Thrombectomy Devices Market, Japan,

2009 138

CORONARY INTRODUCER SHEATHS 139

Chart 11-1: Introducer Sheath Market, Japan, 2006 – 2016 (US$) . 142

Chart 11-2: Introducer Sheaths by Application, Japan, 2006 – 2009 ... 144

Chart 11-3: Leading Competitors, Coronary Introducer Sheath Market, Japan,

2009 147

CORONARY DIAGNOSTIC CATHETERS .... 148

Chart 12-1: Coronary Diagnostic Catheter Market, Japan, 2006 – 2016 (US$) ... 152

Chart 12-2: Leading Competitors, Diagnostic Catheter Market, Japan, 2009 ...... 156

INTRAVASCULAR ULTRASOUND (IVUS) CATHETERS 157

Chart 13-1: IVUS Catheter Market, Japan, 2006 – 2016 (US$) ..... 163

Chart 13-2: Penetration Rates, Intravascular Imaging, Japan, 2006 – 2016 . 165

Chart 13-3: Leading Competitors, IVUS Catheter Market, Japan, 2009 ...... 170

OPTICAL COHERENCE TOMOGRAPHY (OCT) CATHETERS . 171

Chart 14-1: OCT Catheter Market, Japan, 2006 – 2016 (US$) ...... 178

Chart 14-2: Penetration Rates, Intravascular Imaging, Japan, 2006 – 2016 . 180

Chart 14-3: Leading Competitors OCT Catheter Market, Japan, 2009 185

VULNERABLE PLAQUE DEVICES... ... 186

Chart 15-1: Target Population, Potential Market for Vulnerable Plaque

Screening, Japan, 2006 – 2016 ... 192

Chart 15-2: Maximum Potential Market for Vulnerable Plaque, Japan,

2010 – 2015 (US$) 195

TRANSCATHETER CONGENITAL HEART DEFECT CLOSURE DEVICES... 201

Chart 16-1: ASD Closure Devices Market, Japan, 2006 – 2016 (US$) 209

PERCUTANEOUS HEART VALVE DEVICES ...... 215

Chart 17-1: Aortic Valve Replacement Device Market, Japan, 2006 – 2016

(US$) ...... 220

Chart 17-2: Mitral Valve Repair Device Market, Japan, 2006 – 2016 (US$)....... 224

ABBREVIATIONS ... 231

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Cardiovascular Devices Industry: Japanese Market for Interventional Cardiology 2010

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