Microscopy: The Global Market

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Aug 15, 2013, 08:33 ET

NEW YORK, Aug. 15, 2013 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Microscopy: The Global Market
http://www.reportlinker.com/p096650/Microscopy-The-Global-Market.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Imaging

This report provides:

- An overview of the global market for microscopes and accessories, with coverage of optical (light) microscopes, electron microscopes, scanning probe microscopes, and other types (e.g., focused ion beam, confocal).
- Analyses of global market trends, with data from 2012, estimates for 2013, and projections of compound annual growth rates (CAGRs) through 2018.
- Definitions and a brief history of microscopy.
- Microscope technologies.
- Patent analysis.
- Discussion of trends by type of instrument, end-user segment, and geographical region
- Industry structure, including company size and financial performance, ownership, and market shares.
- Comprehensive company profiles of major players in the market.

STUDY BACKGROUND

The field of microscopy has undergone an enormous evolution since the earliest optical microscopes were developed in the 1600s. The optical microscope has been refined continuously since its introduction, resulting in today's superb scientific instruments. However, the optical microscope is ultimately limited in the minimum size and nature of the features that it can resolve by manufacturability constraints and, ultimately, the physics of light itself. New microscopy technologies have been developed to overcome these limitations, such as electron, scanning probe and focused ion beam microscopy. The field of microscopy continues to evolve rapidly as new requirements and imaging technologies are developed. While optical microscopes once accounted for the bulk of all microscopes sold around the world today, they are in the minority today.While microscopes today are a multi-billion-dollar industry, their true importance lies in the activities they make possible, such as life sciences research, microelectronics and advanced-materials science. Microscopy is particularly important to the expanding field of nanotechnology.

STUDY GOALS AND OBJECTIVES

This report is an updated version of an earlier BCC study published in 2011. The goal of this study is to provide the reader with an understanding of recent developments in microscopy technologies and applications and their impact on the future size and structure of the market for various types of microscopes and microscope accessories. Specific study objectives include identifying segments of the microscopy market with the greatest commercial potential in the near- to mid-term (2013 to 2018), identifying and, where possible, quantifying the key demand drivers, projecting future demand for different types of microscopes, and evaluating the technical and other challenges that must be overcome for the market to realize its full potential.

INTENDED AUDIENCE

The report is intended especially for manufacturers and vendors of microscopes and related accessories. Other readers who should find it particularly useful include entrepreneurs, investors, venture capitalists and other readers with a need to know where the microscopy market is headed over the next five years. The report should also be of interest to end users such as nanotechnology companies whose technology road maps may make critical assumptions about the availability and performance of different materials characterization technologies, including microscopes. Other potential readers include members of technical and professional organizations such as ASM International and the American Society for Nondestructive Testing.

SCOPE AND FORMAT

The report addresses the global market for microscopes and microscope accessories over the period from 2012 through 2018, including:
Optical (light) microscopes.
Electron microscopes.
Scanning probe microscopes.
Other types of microscope (e.g., focused ion beam, confocal).
Microscope accessories.
The report includes the following major elements:
Executive summary.
Definitions.
Brief history of microscopy.
Microscope technologies.
Patent analysis.
Major end uses and applications.
Global market trends by type of instrument, end-user segment and geographical region.
Technology trends, limits and challenges.
Industry structure (e.g., firm size and financial performance, ownership, market shares).

METHODOLOGY AND INFORMATION SOURCES

The findings and conclusions of this report are based on information gathered from industry sources, including microscope manufacturers and users. Interview data were combined with information gathered through an extensive review of secondary sources, such as trade publications, trade associations, company literature and online databases, to produce the projections contained in this report. The base year for analysis and projection is 2012. With 2012 as a baseline, market projections were developed for 2013 to 2018. These projections are based on a combination of a consensus among the primary contacts combined with our understanding of the key market drivers and their impact from a historical and an analytical perspective. The analytical methodologies used to generate the market estimates are described in detail in the section on Detailed Market Projections.All dollar projections presented in this report are in 2012 constant U.S. dollars.

CHAPTER 1 INTRODUCTION 2
STUDY BACKGROUND 2
STUDY GOALS AND OBJECTIVES 2
INTENDED AUDIENCE 2
SCOPE AND FORMAT 3
METHODOLOGY AND INFORMATION SOURCES 3
ANALYST CREDENTIALS 3
RELATED BCC REPORTS 4
BCC ONLINE SERVICES 4
DISCLAIMER 5
CHAPTER 2 SUMMARY 7
SUMMARY TABLE MARKET FOR MICROSCOPES, ACCESSORIES AND SUPPLIES,
THROUGH 2018 ($ MILLIONS) 7
SUMMARY FIGURE MARKET FOR MICROSCOPES, ACCESSORIES AND SUPPLIES,
2012-2018 ($ MILLIONS) 7
CHAPTER 3 MICROSCOPY OVERVIEW 10
GENERAL DESCRIPTION 10
DEFINITIONS 10
Charged Particle 10
Compound Microscope 10
Confocal Microscope 10
Depth of Field 10
Dispersion 10
Eyepiece 11
Inverted Microscope 11
Immersion Media 11
Lens 11
FIGURE 1 MAGNIFYING LENS PRINCIPLES 12
Magnification 12
Nanoscale 12
Near-Field 12
Numerical Aperture (NA) 13
Objective 13
Phase Shift 13
FIGURE 2 LIGHT WAVE PHASES 13
Polarization 14
FIGURE 3 POLARIZATION 14
Reflected Light Microscopes 14
Reflecting Microscopes 14
Refraction 15
FIGURE 4 REFRACTION 15
Resolution 16
Scanning Probe 16
Superconducting Quantum Interference Device (SQUID) 16
Stereoscopic 16
Tunneling Current 17
Wavelength 17
FIGURE 5 LIGHT WAVE 17
FIGURE 6 WAVELENGTHS USED IN OPTICAL MICROSCOPY (NM) 17
BRIEF HISTORY OF MICROSCOPY 18
TYPES OF MICROSCOPES 20
OPTICAL MICROSCOPES 20
Description and Applications 20
TABLE 1 TYPES AND MAIN APPLICATIONS OF OPTICAL MICROSCOPES 20
Upright (Compound) Microscopes 21
Binocular Stereomicroscopes 21
Polarizing Microscopes 21
Metallographic Microscopes 22
Reflecting Microscopes 22
FIGURE 7 REFLECTING MICROSCOPE 22
Phase Contrast Microscopes 23
FIGURE 8 BASIC PRINCIPLE OF A PHASE CONTRAST MICROSCOPE 24
Fluorescence Microscope 24
FIGURE 9 FLUORESCENCE MICROSCOPY PRINCIPLES 25
FIGURE 10 FLUORESCENCE MICROSCOPE LAYOUT 26
Confocal Microscopes 27
FIGURE 11 PRINCIPLES OF CONFOCAL MICROSCOPY 28
Scanning Near-Field Optical Microscopes (SNOM) 30
FIGURE 12 SCANNING NEAR-FIELD OPTICAL MICROSCOPE PRINCIPLES 30
Inverted Microscopes 31
Other Types of Optical Microscope 31
Advanced Confocal Microscopy 32
Phase-Sensitive Scatter-Field Optical Imaging 32
Stochastic Optical Reconstruction Microscopy (STORM) 32
Stimulated Emission Depletion Microscopy (STED) 32
Structured Illumination Microscopy (SIM) 33
Second Harmonic Generation (SHG) Microscopy 33
Super-Resolution Fluorescence Microscopy 33
Coherent Anti-Stokes Raman Scattering (CARS) Microscopy 33
Simultaneous Light Scattering Microscopy (LSM) 34
4Pi Microscopy 34
Microsphere Nanoscope 34

Metamaterial-Lens Microscopes 34
Patent Analysis 35
Technologies 35
FIGURE 13 OPTICAL MICROSCOPY PATENTS BY TYPE OF TECHNOLOGY, AS OF JUNE
15, 2013 (PERCENT OF TOTAL PATENTS) 36
TABLE 2 U.S. OPTICAL MICROSCOPY PATENTS AS OF JUNE 15, 2013 (NUMBER OF
PATENTS BY TYPE OF TECHNOLOGY) 36
Trends Over Time 37
FIGURE 14 OPTICAL MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OF
TECHNOLOGY, 2005-2012 (NUMBER OF PATENTS) 37
TABLE 3 OPTICAL MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OF
TECHNOLOGY, 2005-2012 (NUMBER OF PATENTS) 38
Patent Holders 38
FIGURE 15 MAJOR OPTICAL MICROSCOPY PATENT HOLDERS (%) 38
TABLE 4 MAJOR OPTICAL MICROSCOPY PATENT HOLDERS (NUMBER/%) 39
FIGURE 16 MAJOR OPTICAL MICROSCOPY PATENT HOLDERS BY TECHNOLOGY TYPE
(PERCENTAGES OF TOTAL PATENTS) 39
TABLE 5 OPTICAL MICROSCOPY PATENT HOLDERS BY TECHNOLOGY TYPE (NUMBER
OF PATENTS) 40
Manufacturers 40
TABLE 6 OPTICAL MICROSCOPE MANUFACTURERS 41
CHARGED PARTICLE MICROSCOPES 42
Description and Applications 42
TABLE 7 TYPES AND PRIMARY APPLICATIONS OF CHARGED PARTICLE
MICROSCOPES 42
Transmission Electron Microscopes 43
FIGURE 17 TRANSMISSION ELECTRON MICROSCOPE 45
Scanning Electron Microscopes (SEMs) 46
FIGURE 18 SCANNING ELECTRON MICROSCOPE 47
FIGURE 19 SCANNING ELECTRON MICROSCOPE - SAMPLE INTERACTION 47
Environmental Scanning Electron Microscope (ESEM) 48
Field Emission Scanning Electron Microscopes (FESEMs) 49
Field Ion Microscopes (FIM) 49
Other Types of Electron Microscopes 50
Electron Probe Microanalyzer (EPMA) 50
Scanning Transmission Electron Microscopes (STEMs) 50
High-Voltage Electron Microscopes 50
Focused Ion Beam (FIB) Microscopes 51
Reflection Electron Microscope (REM) 52
Low-Energy Electron Microscopy (LEEM) 52

Photoelectron Emission Microscope (PEEM) 52
Patent Analysis 52
Technologies 53
FIGURE 20 U.S. CHARGED PARTICLE MICROSCOPY PATENTS BY TYPE OF
TECHNOLOGY, THROUGH JUNE 15, 2013 (PERCENT OF U.S. PATENTS ISSUED) 53
TABLE 8 U.S. CHARGED PARTICLE MICROSCOPY PATENTS, THROUGH JUNE 15,
2013 (NUMBER AND PERCENT OF U.S. PATENTS) 54
FIGURE 21 CHARGED PARTICLE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE
OF TECHNOLOGY, 2005–2012 (NUMBER OF PATENTS) 55
TABLE 9 CHARGED PARTICLE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE
OF TECHNOLOGY, THROUGH 2012 (NUMBER OF PATENTS) 56
Patent Holders 56
FIGURE 22 CHARGED PARTICLE MICROSCOPE PATENT HOLDERS, THROUGH JUNE
15, 2013 (% OF TOTAL PATENTS ISSUED) 56
TABLE 10 CHARGED PARTICLE MICROSCOPY PATENT HOLDERS, THROUGH JUNE 15,
2013 (NUMBER OF PATENTS ISSUED) 56
FIGURE 23 MAJOR CHARGED PARTICLE MICROSCOPY PATENT HOLDERS BY
TECHNOLOGY TYPE (PERCENT OF TOTAL PATENTS) 57
TABLE 11 MAJOR CHARGED PARTICLE MICROSCOPY PATENT HOLDERS, BY
TECHNOLOGY TYPE (NUMBER OF PATENTS) 58
Manufacturers 58
TABLE 12 CHARGED PARTICLE MICROSCOPE MANUFACTURERS 59
SCANNING-PROBE MICROSCOPES 59
Description and Applications 59
FIGURE 24 SCANNING PROBE MICROSCOPE 59
TABLE 13 TYPES AND PRIMARY APPLICATIONS OF SCANNING PROBE MICROSCOPES 61
Scanning Tunneling Microscopes (STM) 61
Atomic Force Microscopes (AFM) 62
FIGURE 25 ATOMIC FORCE MICROSCOPE PROBE 62
Other Types of Scanning Probe Microscopes 64
Magnetic Force Microscopes (MFMs) 64
Electric Force Microscopes (EFMs) 64
Scanning Thermal Microscopy (SThM) 65
Patent Analysis 65

Technologies 65
FIGURE 26 SCANNING PROBE MICROSCOPY PATENTS BY TYPE OF TECHNOLOGY,
AS OF JUNE 15, 2013 (PERCENT OF TOTAL PATENTS) 66
TABLE 14 U.S. SCANNING PROBE MICROSCOPY PATENTS (NUMBER/%) 66
Trends Over Time 66
FIGURE 27 SCANNING PROBE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE
OF TECHNOLOGY, 2005-2012 (NUMBER OF PATENTS ISSUED ANNUALLY) 66
TABLE 15 SCANNING PROBE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OF
TECHNOLOGY, 2005-2012 (NUMBER OF PATENTS) 67
Patent Holders 68
FIGURE 28 SCANNING PROBE MICROSCOPE PATENT HOLDERS, THROUGH JUNE 15,
2013 (PERCENT OF TOTAL U.S. PATENTS ISSUED) 68
TABLE 16 SCANNING PROBE MICROSCOPY PATENT HOLDERS (NUMBER/%) 69
FIGURE 29 MAJOR SPM PATENT HOLDERS, BY TECHNOLOGY TYPE (PERCENT OF
TOTAL PATENTS) 69
TABLE 17 SCANNING PROBE MICROSCOPY PATENT HOLDERS, BY TECHNOLOGY
TYPE (NUMBER OF PATENTS) 71
Manufacturers 71
TABLE 18 SCANNING PROBE MICROSCOPE MANUFACTURERS 71
ACCESSORIES AND SUPPLIES 72
Description and Applications 72
TABLE 19 MICROSCOPE ACCESSORIES AND THEIR MAIN FUNCTIONS 72
Photomicroscopy Equipment 72
Illumination Systems 73
Microscope Stages and Accessories 73
Eyepieces 74
Objectives 74

Scanning Probes 74
Consumables 75
Patent Analysis 75
Accessory Types 75
FIGURE 30 U.S. MICROSCOPE ACCESSORY PATENTS BY ACCESSORY TYPE, AS OF
JUNE 15, 2013 (PERCENT OF TOTAL PATENTS ISSUED) 76
TABLE 20 U.S. MICROSCOPE ACCESSORY PATENTS (NUMBER/%) 76
Patent Holders 77
FIGURE 31 MICROSCOPE ACCESSORY PATENT HOLDERS, THROUGH JUNE 15, 2013
(PERCENT OF PATENTS ISSUED) 77
TABLE 21 MICROSCOPE ACCESSORY PATENT HOLDERS AND APPLICANTS,
THROUGH JUNE 15, 2013 (%) 77
Manufacturers 78
TABLE 22 MICROSCOPE ACCESSORY MANUFACTURERS 78
END USERS 78
TABLE 23 MICROSCOPE END-USER INDUSTRIES 79
SEMICONDUCTORS 79
Optical Microscopes 80
Charged Particle Microscopes 80
Scanning Probe Microscopes 81
PHOTOVOLTAICS (PV) 81
LIFE SCIENCES 81
TABLE 24 GLOBAL LIFE SCIENCES SALES, 2012 ($ BILLIONS) 82
Optical Microscopes 82
Charged Particle Microscopes 83
MATERIALS SCIENCE 84
FIGURE 32 MATERIALS SCIENCE INSTRUMENTS MAJOR MARKET SEGMENTS, 2012
(PERCENT OF TOTAL SALES) 84
Optical Microscopes 85
Charged Particle Microscopes 85
Scanning Probe Microscopes 86
NANOTECHNOLOGY 87
Charged Particle Microscopes 87
Scanning Probe Microscopes 87
OTHER END USERS 87

Education 88
Optical Microscopes 88
Other Types of Microscopes 88
Environmental Science 88
Optical Microscopes 88
Charged Particle Microscopes 88
Forensics 88
Optical Microscopes 89
Charged Particle Microscopes 89
Food Processing 89
Optical Microscopes 90
Charged Particle Microscopes 90
CHAPTER 4 GLOBAL MARKET FOR MICROSCOPES AND ACCESSORIES 2012
THROUGH 2018 92
OVERALL MARKET SIZE AND SEGMENTATION 92
FIGURE 33 TRENDS IN GLOBAL SALES OF MICROSCOPES AND ACCESSORIES/
SUPPLIES, 2012-2018 ($ MILLIONS) 92
DETAILED MARKET ANALYSIS AND PROJECTIONS 92
MARKET BY TYPE OF INSTRUMENT 92
TABLE 25 PROJECTED GLOBAL MICROSCOPE SALES BY PRODUCT TYPE, THROUGH
2018 ($ MILLIONS) 93
FIGURE 34 MICROSCOPY MAJOR MARKET SEGMENTS, 2012 VERSUS 2018 (%) 94
Optical Microscopes 95
Optical Microscope Market Size and Segmentation 95
FIGURE 35 OPTICAL MICROSCOPE MARKET SEGMENTATION, 2012 (% OF TOTAL
OPTICAL MICROSCOPE SALES) 95
TABLE 26 OPTICAL MICROSCOPE SALES, 2012 ($ MILLIONS/%) 96
Market Drivers 97
Spending on Educational Equipment 97
FIGURE 36 TRENDS IN U.S. EDUCATIONAL EXPENDITURES, 2002–2018 ($ BILLIONS) 97
TABLE 27 U.S. EDUCATIONAL EXPENDITURES, THROUGH 2018 ($ BILLIONS) 98
Trends in Infrared Spectroscopy 99
TABLE 28 GLOBAL MOLECULAR SPECTROMETRY SALES, THROUGH 2018 ($
BILLIONS) 99

Life Sciences R&D and Healthcare Spending 99
FIGURE 37 TRENDS IN LIFE SCIENCES R&D SPENDING, 2012–2018 ($ BILLIONS) 99
TABLE 29 LIFE SCIENCES R&D SPENDING, THROUGH 2018 ($ BILLIONS) 100
Materials Science Instrument Spending 100
FIGURE 38 MATERIALS CHARACTERIZATION INSTRUMENT SALES TRENDS,
2012-2018 ($ BILLIONS) 100
TABLE 30 GLOBAL SPENDING ON MATERIALS CHARACTERIZATION INSTRUMENTS,
THROUGH 2018 ($ BILLIONS) 101
Technology Shift Away From Compound Optical Microscopy 101
Future Market for Optical Microscopes 102
TABLE 31 PROJECTED SALES OF OPTICAL MICROSCOPES, THROUGH 2018 ($
MILLIONS) 102
TABLE 32 PROJECTED GROWTH RATE OF MARKET FOR STEREOSCOPIC
MICROSCOPES, THROUGH 2018 (PERCENT CAGR) 103
TABLE 33 PROJECTED GROWTH RATE OF MARKET FOR SCANNING NEAR-FIELD
OPTICAL MICROSCOPES, THROUGH 2018 (PERCENT CAGR) 103
FIGURE 39 OPTICAL MICROSCOPE MARKET SEGMENTATION, 2018 (%) 104
Charged Particle Microscopes 104
Charged Particle Microscope Market Size and Segmentation 105
FIGURE 40 CHARGED PARTICLE MICROSCOPE MARKET SEGMENTS, 2012 (%) 105
TABLE 34 CHARGED PARTICLE MICROSCOPE SALES, 2012 ($ MILLIONS) 106
Market Drivers 106
Semiconductor Industry Investment Trends 106
FIGURE 41 MARKETS FOR SCANNING ELECTRON MICROSCOPES, 2012 (PERCENT
OF TOTAL SEM SALES) 106
FIGURE 42 PROJECTED GROWTH IN SEMICONDUCTOR CAPITAL EQUIPMENT
SPENDING, 2012-2018 ($ BILLIONS) 107

TABLE 35 SEMICONDUCTOR INDUSTRY CAPITAL EQUIPMENT SPENDING
PROJECTIONS, THROUGH 2018 ($ BILLIONS/CAGR PERCENTAGE) 108
Technology Shifts 108
FIGURE 43 CHARGED PARTICLE MICROSCOPE SALES GROWTH VERSUS GROWTH IN
MAJOR UNDERLYING MARKETS, 2003-2008 (CAGR%) 108
Future Market for Charged Particle Microscopes 110
TABLE 36 PROJECTED SALES OF CHARGED PARTICLE MICROSCOPES, THROUGH
2018 ($ MILLIONS) 110
TABLE 37 PROJECTED GROWTH RATE OF SEM SALES TO THE LIFE AND MATERIALS
SCIENCES, THROUGH 2018 ($ MILLIONS) 111FIGURE 44 CHARGED PARTICLE MICROSCOPE MARKET SEGMENTS, 2018 (PERCENT
OF TOTAL SALES) 112
Scanning Probe Microscopes 112
Scanning Probe Microscope Market Size and Segmentation 113
FIGURE 45 SPM MARKET PRODUCT SEGMENTS, 2012 (%) 113
Market Drivers 114
Trends in Nanoscale Applications 114
Technology Shifts 114
Future Market for Scanning Probe Microscopes 115
TABLE 38 PROJECTED SALES OF SCANNING PROBE MICROSCOPES, THROUGH 2018
($ MILLIONS) 115
FIGURE 46 SCANNING PROBE MICROSCOPE MARKET SEGMENTS, 2018 (PERCENT
OF TOTAL SALES) 116
Accessories and Supplies 116
Market Size and Segmentation 116
FIGURE 47 MICROSCOPE ACCESSORIES AND SUPPLIES MARKET SEGMENTATION,
2012 (%) 117
TABLE 39 SALES OF MICROSCOPE ACCESSORIES AND CONSUMABLES, 2012 ($
MILLIONS/%) 117
Market Drivers 117
Number of Microscopes in Use Worldwide 117
FIGURE 48 TRENDS IN NUMBER OF MICROSCOPES IN USE WORLDWIDE, 2011-2018
(MILLION UNITS) 118
TABLE 40 NUMBER OF MICROSCOPES IN USE WORLDWIDE, THROUGH 2018
(MILLION UNITS) 118

Future Markets for Microscope Accessories and Supplies 118
TABLE 41 PROJECTED SALES OF MICROSCOPE ACCESSORIES AND SUPPLIES,
THROUGH 2018 ($ MILLIONS) 119
MARKETS BY END-USER SEGMENT 119
Optical Microscopes 119
FIGURE 49 OPTICAL MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2012
VERSUS 2018 (%) 120
TABLE 42 END-USER MARKETS FOR OPTICAL MICROSCOPES, THROUGH 2018 ($
MILLIONS) 121
Charged Particle Microscopes 121
FIGURE 50 CHARGED PARTICLE MICROSCOPE MARKET SHARES BY END-USER
SEGMENT, 2012 VERSUS 2018 (%) 122
TABLE 43 END-USER MARKETS FOR CHARGED PARTICLE MICROSCOPES, THROUGH
2018 ($ MILLIONS) 123
Scanning Probe Microscopes 123
All Types of Microscopes 123
FIGURE 51 MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2012 VERSUS
2018 (%) 123
TABLE 44 END-USER MARKETS FOR ALL TYPES OF MICROSCOPES*, THROUGH 2018
($ MILLIONS) 125
GEOGRAPHICAL MARKETS 125
Optical Microscopes 125
FIGURE 52 OPTICAL MICROSCOPE GEOGRAPHICAL MARKET SHARES, 2012 VERSUS
2018 (%) 125
TABLE 45 GEOGRAPHICAL MARKETS FOR OPTICAL MICROSCOPES, THROUGH 2018
($ MILLIONS) 127
Charged Particle Microscopes 127
FIGURE 53 CHARGED PARTICLE MICROSCOPE GEOGRAPHICAL MARKET SHARES,
2012 VERSUS 2018 (%) 127
TABLE 46 GEOGRAPHICAL MARKETS FOR CHARGED PARTICLE MICROSCOPES,
THROUGH 2018 ($ MILLIONS) 129
Scanning Probe Microscopes 129
FIGURE 54 SCANNING PROBE MICROSCOPE GEOGRAPHICAL MARKET SHARES,
2012 VERSUS 2018 (%) 130
TABLE 47 GEOGRAPHICAL MARKETS FOR SCANNING PROBE MICROSCOPES,
THROUGH 2018 ($ MILLIONS) 131
Types of Microscopes 131

FIGURE 55 MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2012 VERSUS
2018 (%) 131
TABLE 48 GEOGRAPHICAL MARKETS FOR ALL TYPES OF MICROSCOPES,* THROUGH
2018 ($ MILLIONS) 133
CHAPTER 5 INDUSTRY STRUCTURE 135
MARKET SHARES 135
OPTICAL MICROSCOPES 135
FIGURE 56 OPTICAL MICROSCOPY MARKET SHARES, 2012 (%) 135
CHARGED PARTICLE MICROSCOPES 136
Electron Microscopes 136
FIGURE 57 ELECTRON MICROSCOPE MARKET SHARES, 2012 (%) 136
Focused Ion Beam Microscopes 137
FIGURE 58 FOCUSED ION BEAM MICROSCOPE MARKET SHARES, 2012 (%) 137
SCANNING PROBE MICROSCOPES 138
FIGURE 59 SCANNING PROBE MICROSCOPE MARKET SHARES, 2012 (%) 138
OWNERSHIP TRENDS 138
CHAPTER 6 COMPANY PROFILES 142
APPLIED MATERIALS, INC. 142
BRUKER AXS 142
BRUKER OPTICS INC. 142
BUEHLER INC. 142
CAMECA SA 143
DANISH MICRO ENGINEERING A/S 143
FEI COMPANY 143
GATAN, INC. 144
HITACHI HIGH TECHNOLOGIES CORP. 144
JASCO INTERNATIONAL CO. LTD. 144
JEOL LTD. 145
LEICA MICROSYSTEMS AG 145
MIS INC. 145
NANONICS IMAGING LTD. 146
NANOSURF AG 146
NIKON CORP. 146
NT-MDT CO. 147
OBDUCAT-CAMSCAN LTD. 147
OLYMPUS CORPORATION 147
OMICRON NANOTECHNOLOGY GMBH 147
PARK SYSTEMS CORP. 148
PERKIN ELMER, INC. 148
QUESTAR CORP. 148
SCHOTT NORTH AMERICA INC. 148
SHIMADZU CORP. 149
SII NANOTECHNOLOGY INC. 149
THERMO FISHER SCIENTIFIC INC. 149
VEECO INSTRUMENTS INC. 149
WITEC WISSENSCHAFTLICHE INSTRUMENTE UND TECHNOLOGIE GMBH 150
ZEISS (CARL) NTS GMBH 150

LIST OF TABLES

SUMMARY TABLE MARKET FOR MICROSCOPES, ACCESSORIES AND SUPPLIES,
THROUGH 2018 ($ MILLIONS) 7
TABLE 1 TYPES AND MAIN APPLICATIONS OF OPTICAL MICROSCOPES 20
TABLE 2 U.S. OPTICAL MICROSCOPY PATENTS AS OF JUNE 15, 2013 (NUMBER OF
PATENTS BY TYPE OF TECHNOLOGY) 36
TABLE 3 OPTICAL MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OF
TECHNOLOGY, 2005-2012 (NUMBER OF PATENTS) 38
TABLE 4 MAJOR OPTICAL MICROSCOPY PATENT HOLDERS (NUMBER/%) 39
TABLE 5 OPTICAL MICROSCOPY PATENT HOLDERS BY TECHNOLOGY TYPE (NUMBER
OF PATENTS) 40
TABLE 6 OPTICAL MICROSCOPE MANUFACTURERS 41
TABLE 7 TYPES AND PRIMARY APPLICATIONS OF CHARGED PARTICLE MICROSCOPES 42
TABLE 8 U.S. CHARGED PARTICLE MICROSCOPY PATENTS, THROUGH JUNE 15, 2013
(NUMBER AND PERCENT OF U.S. PATENTS) 54
TABLE 9 CHARGED PARTICLE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OF
TECHNOLOGY, THROUGH 2012 (NUMBER OF PATENTS) 56
TABLE 10 CHARGED PARTICLE MICROSCOPY PATENT HOLDERS, THROUGH JUNE 15,
2013 (NUMBER OF PATENTS ISSUED) 56
TABLE 11 MAJOR CHARGED PARTICLE MICROSCOPY PATENT HOLDERS, BY
TECHNOLOGY TYPE (NUMBER OF PATENTS) 58
TABLE 12 CHARGED PARTICLE MICROSCOPE MANUFACTURERS 59
TABLE 13 TYPES AND PRIMARY APPLICATIONS OF SCANNING PROBE MICROSCOPES 61
TABLE 14 U.S. SCANNING PROBE MICROSCOPY PATENTS (NUMBER/%) 66
TABLE 15 SCANNING PROBE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OF
TECHNOLOGY, 2005-2012 (NUMBER OF PATENTS) 67
TABLE 16 SCANNING PROBE MICROSCOPY PATENT HOLDERS (NUMBER/%) 69
TABLE 17 SCANNING PROBE MICROSCOPY PATENT HOLDERS, BY TECHNOLOGY TYPE
(NUMBER OF PATENTS) 71
TABLE 18 SCANNING PROBE MICROSCOPE MANUFACTURERS 71
TABLE 19 MICROSCOPE ACCESSORIES AND THEIR MAIN FUNCTIONS 72
TABLE 20 U.S. MICROSCOPE ACCESSORY PATENTS (NUMBER/%) 76
TABLE 21 MICROSCOPE ACCESSORY PATENT HOLDERS AND APPLICANTS, THROUGH
JUNE 15, 2013 (%) 77
TABLE 22 MICROSCOPE ACCESSORY MANUFACTURERS 78
TABLE 23 MICROSCOPE END-USER INDUSTRIES 79
TABLE 24 GLOBAL LIFE SCIENCES SALES, 2012 ($ BILLIONS) 82
TABLE 25 PROJECTED GLOBAL MICROSCOPE SALES BY PRODUCT TYPE, THROUGH
2018 ($ MILLIONS) 93
TABLE 26 OPTICAL MICROSCOPE SALES, 2012 ($ MILLIONS/%) 96
TABLE 27 U.S. EDUCATIONAL EXPENDITURES, THROUGH 2018 ($ BILLIONS) 98
TABLE 28 GLOBAL MOLECULAR SPECTROMETRY SALES, THROUGH 2018 ($ BILLIONS) 99
TABLE 29 LIFE SCIENCES R&D SPENDING, THROUGH 2018 ($ BILLIONS) 100
TABLE 30 GLOBAL SPENDING ON MATERIALS CHARACTERIZATION INSTRUMENTS,
THROUGH 2018 ($ BILLIONS) 101
TABLE 31 PROJECTED SALES OF OPTICAL MICROSCOPES, THROUGH 2018 ($
MILLIONS) 102
TABLE 32 PROJECTED GROWTH RATE OF MARKET FOR STEREOSCOPIC
MICROSCOPES, THROUGH 2018 (PERCENT CAGR) 103
TABLE 33 PROJECTED GROWTH RATE OF MARKET FOR SCANNING NEAR-FIELD
OPTICAL MICROSCOPES, THROUGH 2018 (PERCENT CAGR) 103
IAS017E - Microscopy: The Global Market
Copyright © BCC Research, Wellesley MA USA, Website: www.bccresearch.com
TABLE HEADING PAGE NO.

TABLE 34 CHARGED PARTICLE MICROSCOPE SALES, 2012 ($ MILLIONS) 106
TABLE 35 SEMICONDUCTOR INDUSTRY CAPITAL EQUIPMENT SPENDING
PROJECTIONS, THROUGH 2018 ($ BILLIONS/CAGR PERCENTAGE) 108
TABLE 36 PROJECTED SALES OF CHARGED PARTICLE MICROSCOPES, THROUGH
2018 ($ MILLIONS) 110
TABLE 37 PROJECTED GROWTH RATE OF SEM SALES TO THE LIFE AND MATERIALS
SCIENCES, THROUGH 2018 ($ MILLIONS) 111
TABLE 38 PROJECTED SALES OF SCANNING PROBE MICROSCOPES, THROUGH 2018
($ MILLIONS) 115
TABLE 39 SALES OF MICROSCOPE ACCESSORIES AND CONSUMABLES, 2012 ($
MILLIONS/%) 117
TABLE 40 NUMBER OF MICROSCOPES IN USE WORLDWIDE, THROUGH 2018
(MILLION UNITS) 118
TABLE 41 PROJECTED SALES OF MICROSCOPE ACCESSORIES AND SUPPLIES,
THROUGH 2018 ($ MILLIONS) 119
TABLE 42 END-USER MARKETS FOR OPTICAL MICROSCOPES, THROUGH 2018 ($
MILLIONS) 121
TABLE 43 END-USER MARKETS FOR CHARGED PARTICLE MICROSCOPES, THROUGH
2018 ($ MILLIONS) 123
TABLE 44 END-USER MARKETS FOR ALL TYPES OF MICROSCOPES*, THROUGH 2018
($ MILLIONS) 125
TABLE 45 GEOGRAPHICAL MARKETS FOR OPTICAL MICROSCOPES, THROUGH 2018
($ MILLIONS) 127
TABLE 46 GEOGRAPHICAL MARKETS FOR CHARGED PARTICLE MICROSCOPES,
THROUGH 2018 ($ MILLIONS) 129
TABLE 47 GEOGRAPHICAL MARKETS FOR SCANNING PROBE MICROSCOPES,
THROUGH 2018 ($ MILLIONS) 131
TABLE 48 GEOGRAPHICAL MARKETS FOR ALL TYPES OF MICROSCOPES,* THROUGH
2018 ($ MILLIONS) 133

LIST OF FIGURES

SUMMARY FIGURE MARKET FOR MICROSCOPES, ACCESSORIES AND SUPPLIES,
2012-2018 ($ MILLIONS) 7
FIGURE 1 MAGNIFYING LENS PRINCIPLES 12
FIGURE 2 LIGHT WAVE PHASES 13
FIGURE 3 POLARIZATION 14
FIGURE 4 REFRACTION 15
FIGURE 5 LIGHT WAVE 17
FIGURE 6 WAVELENGTHS USED IN OPTICAL MICROSCOPY (NM) 17
FIGURE 7 REFLECTING MICROSCOPE 22
FIGURE 8 BASIC PRINCIPLE OF A PHASE CONTRAST MICROSCOPE 24
FIGURE 9 FLUORESCENCE MICROSCOPY PRINCIPLES 25
FIGURE 10 FLUORESCENCE MICROSCOPE LAYOUT 26
FIGURE 11 PRINCIPLES OF CONFOCAL MICROSCOPY 28
FIGURE 12 SCANNING NEAR-FIELD OPTICAL MICROSCOPE PRINCIPLES 30
FIGURE 13 OPTICAL MICROSCOPY PATENTS BY TYPE OF TECHNOLOGY, AS OF JUNE
15, 2013 (PERCENT OF TOTAL PATENTS) 36
FIGURE 14 OPTICAL MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OF
TECHNOLOGY, 2005-2012 (NUMBER OF PATENTS) 37
FIGURE 15 MAJOR OPTICAL MICROSCOPY PATENT HOLDERS (%) 38
FIGURE 16 MAJOR OPTICAL MICROSCOPY PATENT HOLDERS BY TECHNOLOGY TYPE
(PERCENTAGES OF TOTAL PATENTS) 39
FIGURE 17 TRANSMISSION ELECTRON MICROSCOPE 45
FIGURE 18 SCANNING ELECTRON MICROSCOPE 47
FIGURE 19 SCANNING ELECTRON MICROSCOPE - SAMPLE INTERACTION 47
FIGURE 20 U.S. CHARGED PARTICLE MICROSCOPY PATENTS BY TYPE OF
TECHNOLOGY, THROUGH JUNE 15, 2013 (PERCENT OF U.S. PATENTS ISSUED) 53
FIGURE 21 CHARGED PARTICLE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE
OF TECHNOLOGY, 2005–2012 (NUMBER OF PATENTS) 55
FIGURE 22 CHARGED PARTICLE MICROSCOPE PATENT HOLDERS, THROUGH JUNE 15,
2013 (% OF TOTAL PATENTS ISSUED) 56
FIGURE 23 MAJOR CHARGED PARTICLE MICROSCOPY PATENT HOLDERS BY
TECHNOLOGY TYPE (PERCENT OF TOTAL PATENTS) 57
FIGURE 24 SCANNING PROBE MICROSCOPE 59
FIGURE 25 ATOMIC FORCE MICROSCOPE PROBE 62
FIGURE 26 SCANNING PROBE MICROSCOPY PATENTS BY TYPE OF TECHNOLOGY, AS
OF JUNE 15, 2013 (PERCENT OF TOTAL PATENTS) 66
FIGURE 27 SCANNING PROBE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OF
TECHNOLOGY, 2005-2012 (NUMBER OF PATENTS ISSUED ANNUALLY) 66
FIGURE 28 SCANNING PROBE MICROSCOPE PATENT HOLDERS, THROUGH JUNE 15,
2013 (PERCENT OF TOTAL U.S. PATENTS ISSUED) 68
FIGURE 29 MAJOR SPM PATENT HOLDERS, BY TECHNOLOGY TYPE (PERCENT OF
TOTAL PATENTS) 69
FIGURE 30 U.S. MICROSCOPE ACCESSORY PATENTS BY ACCESSORY TYPE, AS OF
JUNE 15, 2013 (PERCENT OF TOTAL PATENTS ISSUED) 76
FIGURE 31 MICROSCOPE ACCESSORY PATENT HOLDERS, THROUGH JUNE 15, 2013
(PERCENT OF PATENTS ISSUED) 77
FIGURE 32 MATERIALS SCIENCE INSTRUMENTS MAJOR MARKET SEGMENTS, 2012
(PERCENT OF TOTAL SALES) 84
FIGURE 33 TRENDS IN GLOBAL SALES OF MICROSCOPES AND ACCESSORIES/
SUPPLIES, 2012-2018 ($ MILLIONS) 92
FIGURE 34 MICROSCOPY MAJOR MARKET SEGMENTS, 2012 VERSUS 2018 (%) 94
FIGURE 35 OPTICAL MICROSCOPE MARKET SEGMENTATION, 2012 (% OF TOTAL
OPTICAL MICROSCOPE SALES) 95
FIGURE 36 TRENDS IN U.S. EDUCATIONAL EXPENDITURES, 2002–2018 ($ BILLIONS) 97
FIGURE 37 TRENDS IN LIFE SCIENCES R&D SPENDING, 2012–2018 ($ BILLIONS) 99
FIGURE 38 MATERIALS CHARACTERIZATION INSTRUMENT SALES TRENDS,
2012-2018 ($ BILLIONS) 100
FIGURE 39 OPTICAL MICROSCOPE MARKET SEGMENTATION, 2018 (%) 104
FIGURE 40 CHARGED PARTICLE MICROSCOPE MARKET SEGMENTS, 2012 (%) 105
FIGURE 41 MARKETS FOR SCANNING ELECTRON MICROSCOPES, 2012 (PERCENT OF
TOTAL SEM SALES) 106
FIGURE 42 PROJECTED GROWTH IN SEMICONDUCTOR CAPITAL EQUIPMENT
SPENDING, 2012-2018 ($ BILLIONS) 107
FIGURE 43 CHARGED PARTICLE MICROSCOPE SALES GROWTH VERSUS GROWTH IN
MAJOR UNDERLYING MARKETS, 2003-2008 (CAGR%) 108
FIGURE 44 CHARGED PARTICLE MICROSCOPE MARKET SEGMENTS, 2018 (PERCENT
OF TOTAL SALES) 112
FIGURE 45 SPM MARKET PRODUCT SEGMENTS, 2012 (%) 113
FIGURE 46 SCANNING PROBE MICROSCOPE MARKET SEGMENTS, 2018 (PERCENT OF
TOTAL SALES) 116

FIGURE 47 MICROSCOPE ACCESSORIES AND SUPPLIES MARKET SEGMENTATION,
2012 (%) 117
FIGURE 48 TRENDS IN NUMBER OF MICROSCOPES IN USE WORLDWIDE, 2011-2018
(MILLION UNITS) 118
FIGURE 49 OPTICAL MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2012
VERSUS 2018 (%) 120
FIGURE 50 CHARGED PARTICLE MICROSCOPE MARKET SHARES BY END-USER
SEGMENT, 2012 VERSUS 2018 (%) 122
FIGURE 51 MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2012 VERSUS
2018 (%) 123
FIGURE 52 OPTICAL MICROSCOPE GEOGRAPHICAL MARKET SHARES, 2012 VERSUS
2018 (%) 125
FIGURE 53 CHARGED PARTICLE MICROSCOPE GEOGRAPHICAL MARKET SHARES,
2012 VERSUS 2018 (%) 127
FIGURE 54 SCANNING PROBE MICROSCOPE GEOGRAPHICAL MARKET SHARES, 2012
VERSUS 2018 (%) 130
FIGURE 55 MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2012 VERSUS
2018 (%) 131
FIGURE 56 OPTICAL MICROSCOPY MARKET SHARES, 2012 (%) 135
FIGURE 57 ELECTRON MICROSCOPE MARKET SHARES, 2012 (%) 136
FIGURE 58 FOCUSED ION BEAM MICROSCOPE MARKET SHARES, 2012 (%) 137
FIGURE 59 SCANNING PROBE MICROSCOPE MARKET SHARES, 2012 (%) 138