MD Anderson, AbbVie Connect to Advance Cancer Immunotherapy

News provided by

Jan 21, 2016, 08:30 ET

HOUSTON and NORTH CHICAGO, Ill., Jan. 21, 2016 /PRNewswire/ -- The immunotherapy platform at The University of Texas MD Anderson Cancer Center and the global biopharmaceutical company AbbVie (NYSE: ABBV) will join forces to find new ways to unleash the immune system's potential to fight cancer.

The three-year collaboration agreement provides a framework for MD Anderson and AbbVie to efficiently choose and carry out preclinical and clinical studies evaluating new ideas in the cutting-edge area of immuno-oncology.

"AbbVie has both identified new molecules and developed novel technology to hit key targets, with the objective of designing new immunotherapy for the benefit of patients," said Padmanee Sharma, M.D., Ph.D., immunotherapy platform scientific director and professor of Genitourinary Medical Oncology and Immunology at MD Anderson.

Existing immunotherapy drugs thwart tumors and significantly extend survival in groups of patients with advanced melanoma and lung cancer, and they also are being tested in other cancer types. Jim Allison, Ph.D., executive director of the immunotherapy platform and chair of Immunology at MD Anderson, notes there are many more potential targets for drugs to mobilize the immune system to attack other cancers.

"Cancer immunotherapy drugs that remove two types of brakes on immune response are really just the tip of the iceberg for this field," Allison said. "Our agreements with companies such as AbbVie allow academic and industry scientists to work efficiently to move the science forward and extend this approach to more patients."

AbbVie's research efforts in immunotherapy leverage the company's strengths in biology, protein engineering and chemistry.

"Pairing MD Anderson's cutting-edge preclinical, translational and clinical capabilities with AbbVie's innovative discovery and development programs accelerates our ability to deliver new therapies that can help transform the lives of people affected by cancer," said Michael Severino, M.D., executive vice president, R&D and chief scientific officer, AbbVie. "AbbVie is pleased to partner with MD Anderson's world-class experts so that together we can advance the science of cancer immunotherapy for the benefit of patients around the world."

AbbVie and MD Anderson will each assign two scientists to a joint scientific committee, which decides on projects to pursue. "With the collaboration agreement in place, we can move quickly to design and implement new studies, clinical trials, and exchanges of reagents and take other actions without having to reach new, separate agreements," Sharma said.

The collaboration will get underway with projects driven by AbbVie Biotherapeutics, AbbVie's center of innovation in the biotech hub of the San Francisco Bay Area. Future projects will draw from the extensive portfolio of oncology programs across the AbbVie Oncology pipeline.

The AbbVie agreement is the first of a limited number to come in a new wave of such collaborations with MD Anderson's immunotherapy platform, said Ferran Prat, Ph.D., J.D., vice president of Strategic Ventures.

MD Anderson's immunotherapy platform combines expertise and advanced technology for preclinical modeling, innovative clinical trials and immune monitoring before, during and after treatment to better understand drug mechanisms and identify biomarkers to guide treatment. The platform works collaboratively with a select group of pharmaceutical companies and also is part of MD Anderson's Moon Shots Program, a transdisciplinary initiative to accelerate development of new treatments and prevention programs deriving from scientific discoveries.

Platform leader Allison invented the breakthrough immunotherapy approach called immune checkpoint blockade, which uses antibodies to block proteins on the surface of T cells that otherwise shut down T cells' attack on cancer.

About MD Anderson

The University of Texas MD Anderson Cancer Center in Houston ranks as one of the world's most respected centers focused on cancer patient care, research, education and prevention. The institution's sole mission is to end cancer for patients and their families around the world. MD Anderson is one of only 45 comprehensive cancer centers designated by the National Cancer Institute (NCI). MD Anderson is ranked No.1 for cancer care in U.S. News & World Report's "Best Hospital's" survey. It has ranked as one of the nation's top two hospitals since the survey began in 1990, and has ranked first for 11 of the past 14 years. MD Anderson receives a cancer center support grant from the NCI of the National Institutes of Health (P30 CA016672).

About AbbVie

AbbVie is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. The company's mission is to use its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world's most complex and serious diseases. Together with its wholly-owned subsidiary, Pharmacyclics, AbbVie employs more than 28,000 people worldwide and markets medicines in more than 170 countries. For further information on the company and its people, portfolio and commitments, please visit www.abbvie.com. Follow @abbvie on Twitter or view careers on our Facebook or LinkedIn page.

SOURCE AbbVie