Global Biopharmaceutical Bioseparation Systems Industry

LONDON, Feb. 29, 2016 /PRNewswire/ -- This report analyzes the worldwide markets for Biopharmaceutical Bioseparation Systems in US$ Million by the following Product Segments: Chromatography Systems, and Other Bioseparation Systems. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Middle East & Africa, and Latin America. Annual estimates and forecasts are provided for the period 2014 through 2020. Also, a four-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 52 companies including many key and niche players such as -

3M Company
Agilent Technologies, Inc.
Alfa Wassermann Separation Technologies, LLC
Flottweg Separation Technology
GEA Westfalia Separator Group GmbH

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I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations I-1 Disclaimers.............. I-2 Data Interpretation & Reporting Level I-2 Quantitative Techniques & Analytics I-3 Product Definitions and Scope of Study I-3

II. EXECUTIVE SUMMARY

1. OUTLOOK.............. II-1 Bioseparation Systems - Invaluable Tools in Biopharmaceutical Manufacturing.............. II-1 US Remains Market Leader; Developing Countries to Drive Market Growth.............. II-2 Chromatography Leads the Pack II-2 Competitive Landscape..............II-3 Table 1: Leading Players in the Global Biopharmaceutical Bioseparation Systems Market (2014): Percentage Breakdown of Revenues for 3M Purification, GE Healthcare Life Sciences, Merck Millipore, Pall Corporation, Sartorius and Others (includes corresponding Graph/Chart) II-3

2. INDUSTRY OVERVIEW.............. II-4 A Peek into Biopharmaceutical Manufacturing II-4 Downstream Processing of Biosynthetic Products - An Overview II-4 Growing Biopharmaceuticals Market Drives Demand for Bioseparation Systems..............II-5 2014-15: A Launch-Driven Period for Biopharmaceuticals II-6 Recently Approved Biopharmaceuticals: 2013, 2014 & 2015 II-7 Biopharmaceutical Industry Transforms Downstream Processing II-8 Growing Market for Monoclonal Antibodies - A Key Review of Current Status and Future Prospects II-9 Approved Monoclonal Antibodies for Therapeutic Use: 1986-2014 II-10 An Insight into Bioseparation of mAbs II-11 Growing Biosimilars Market - A Clear Advantage for Bioseparation Technologies..............II-11 Table 2: Global Biosimilars Market Size Estimates and Forecasts: 2012-2018F (includes corresponding Graph/Chart) II-12 2015: A year of Patent Expiries for Biologics II-12 Patent Expiries of Major Biopharmaceutical Drugs in the US and Europe.............. II-12 R&D Funding Crucial for Biologics and Bioseparation market II-13 Table 3: Global Biopharmaceutical R&D Expenditure: 2010- 2015E (includes corresponding Graph/Chart) II-14 Huge Biopharmaceutical Pipeline - A Clear Indicator of Future Prospects.............. II-14 Table 4: Biopharmaceutical Products' Pipeline by Therapeutic Category (2015) (includes corresponding Graph/Chart) II-15

Table 5: No. of Pipeline Biopharmaceuticals for Cancer by Site (2015) (includes corresponding Graph/Chart) II-16

Table 6: No. of Pipeline Biopharmaceuticals for HIV/AIDS Treatment by Type of Therapy (2015) (includes corresponding Graph/Chart).............. II-16 Insulin Products in Development II-16 Growing Biological Drug Manufacturing Capacity to Drive Growth II-17

3. BIOSEPARATION TECHNOLOGIES - KEY TRENDS II-18 Increasing Need for Further Advances in Downstream Processing Techniques.............. II-18 Process Optimization and Cost Reduction - Key Goals of Innovations in Bioseparation II-18 Single-Use Disposable Technologies Gain Attention II-18 Select Commercial Disposable/Single-Use Technologies by Process Technique.............. II-20 Innovations in Single-use Systems II-21 Changing Paradigm of Primary Recovery in Bioseparation II-21 Growing Use of Membrane Filtration in Biopharmaceutical Manufacturing.............. II-22 Chromatography - the Gold Standard Purification Technology II-22 Bioprocess Membrane Technology Offers Significant Benefits over Conventional Technologies II-23 Superior Efficiency Drives Use of Synthetic Ligands in Affinity Chromatography..............II-23 A Comparison of Protein and Synthetic Ligands II-24 Increasing Alternatives to Protein A Column based Capturing II-24 Twin-Column SMB - An Emerging Alternative to Protein A Columns II-25 Inherent Benefits of Membrane Chromatography to Drive its Use in Bioprocessing..............II-25 SMBC - An Old Approach Gaining Significant Attention II-26 A Comparison of Major Advantages and Disadvantages of SMBC II-26 Magnetic Separation as an Alternative to Chromatography - A Review.............. II-26 Reversible Precipitation - A Novel Bioseparation Technology II-27

4. PRODUCT OVERVIEW.............. II-28 Biological Products - An Overview II-28 Classification of Biological Products by Application II-28 Classification of Biological Products by Chemical Nature II-28 Bioseparation - An Overview..............II-29 Commonly Used Bioseparation Processes by Factors II-29 Bioseparation - A Challenging, Complex and Expensive Process II-30 Stages of Biomolecule Recovery and Relevant Bioseparation Techniques Used.............. II-30 Classification of Bioseparation Techniques based on Resolution and Throughput..............II-31 Bioseparation Costs as a Percentage of Processing by Biological Product..............II-31 Key Bioseparation Techniques..............II-31 Chromatography.............. II-31 Centrifugation.............. II-32 Membrane Separation..............II-32 Filtration.............. II-32 Overview of Other Bioseparation Techniques II-32 Adsorption.............. II-32 Extraction.............. II-33 Precipitation.............. II-33 Classification of Bioseparation Techniques based on Physical Form II-33 Particle-Liquid Separation..............II-33 Particle-Particle Separation..............II-33 Solute-Solvent Separation..............II-33 Solute-Solute Separation..............II-34 Liquid-Liquid Separation..............II-34 Particle-Solute Separation..............II-34 RIPP in Bioseparation - The Conventional Scheme for Developing Processes.............. II-34

5. RECENT INDUSTRY ACTIVITY..............II-36 Merck Acquires Sigma-Aldrich..............II-36 EMD Millipore Launches Sterilizing-Grade Millipore Express® PHF Hydrophilic Filters..............II-36 Anteo Diagnostics Inks South Korean Distribution Agreement with KomaBiotech.............. II-36 GE Healthcare and Sartorius Stedim Biotech Ink OEM Supply Agreement for Sartobind™ Technology II-36 EMD Millipore Unveils Pellicon® Tangential Flow Filtration System II-36 ImmunoReagents and ProteoVec Launch PV-Pure Ig™ Antibody Purification Kits..............II-36 Pall Acquires Tarpon's BioSMB Platform II-37 AMSBIO Introduces MagSi-Direct for Bioseparations II-37 EMD Millipore Rolls Out PureFlex™ Plus Disposable Process Container Film.............. II-37 EMD Millipore Rolls Out New Resins for Chromabolt® Chromatography Columns..............II-37 Thermo Fisher Scientific Launches New Chromatography Resin II-37 Thermo Fisher Scientific to Introduce GlycanPac AXR-1 Column at Pittcon 2014.............. II-37 Pall Corporation Acquires ATMI's Life Sciences Business Division II-37 Purolite to Develop Bioseparation Resins for Chromatography II-38 EMD Millipore Unveils Innovative Single-Stage Clarification Clarisolve® Depth Filters..............II-38 Thermo Fisher Scientific Introduces New 3000 BioRS System II-38 Thermo Fisher Scientific Launches SEC-300 and SEC-1000 HPLC Columns.............. II-38 EMD Millipore Introduces Smart Flexware® Assemblies Along with Mobius® FlexReady Solution..............II-38

6. FOCUS ON SELECT PLAYERS..............II-39 3M Company (US).............. II-39 3M Purification, Inc. (US)..............II-39 Agilent Technologies, Inc. (US)..............II-39 Alfa Wassermann Separation Technologies, LLC (US) II-40 Flottweg Separation Technology (US) II-40 GEA Westfalia Separator Group GmbH (Germany) II-41 GE Healthcare (UK)..............II-41 KNAUER Wissenschaftliche Geräte GmbH (Germany) II-41 Konik Nanobiotech SL (Spain)..............II-42 Merck KGaA (Germany)..............II-42 NuSep Holdings Ltd. (Australia)..............II-43 Pall Corporation (US)..............II-43 ProMetic Life Sciences, Inc. (Canada) II-44 Sartorius Stedim Biotech (France) II-44 Spectrum Laboratories, Inc. (US) II-45 Thermo Fisher Scientific, Inc. (US) II-45 Tosoh Bioscience, Inc. (Japan) II-46 YMC Europe GmbH (Germany)..............II-46

7. GLOBAL MARKET PERSPECTIVE..............II-47 Table 7: World Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Middle East & Africa and Latin American Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart) II-47

Table 8: World Historic Review for Biopharmaceutical Bioseparation Systems by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Middle East & Africa and Latin American Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) II-48

Table 9: World 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Geographic Region - Percentage Breakdown of Revenues for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Middle East & Africa and Latin American Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart)..............II-49

Table 10: World Recent Past, Current & Future Analysis for Chromatography Systems for Biopharmaceutical Bioseparation by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Middle East & Africa and Latin American Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart)..............II-50

Table 11: World Historic Review for Chromatography Systems for Biopharmaceutical Bioseparation by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Middle East & Africa and Latin American Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) II-51

Table 12: World 11-Year Perspective for Chromatography Systems for Biopharmaceutical Bioseparation by Geographic Region - Percentage Breakdown of Revenues for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Middle East & Africa and Latin American Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart) II-52

Table 13: World Recent Past, Current & Future Analysis for Other Biopharmaceutical Bioseparation Systems by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Middle East & Africa and Latin American Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. II-53

Table 14: World Historic Review for Other Biopharmaceutical Bioseparation Systems by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Middle East & Africa and Latin American Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) II-54

Table 15: World 11-Year Perspective for Other Biopharmaceutical Bioseparation Systems by Geographic Region - Percentage Breakdown of Revenues for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Middle East & Africa and Latin American Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart) II-55

III. MARKET

1. THE UNITED STATES.............. III-1 A.Market Analysis.............. III-1 Current & Future Analysis..............III-1 United States: The Largest Biopharmaceutical Market Globally III-1 Table 16: No. of Biologics Approved by the Center for Biologics Evaluation and Research (CBER): 2003-2013 (includes corresponding Graph/Chart) III-1 Impending Patent Expiries Signal Growth Prospects III-2 Table 17: Leading US Biopharmaceuticals by Revenue (in US$ Billion) and Year of Patent Expiry (includes corresponding Graph/Chart).............. III-3 Select Trends in Biopharmaceutical Market III-3 Manufacturers Shift Focus to Small Bioreactors III-3 Biosimilar Drug Developers Face Higher Litigation Risks III-4 Strategic Corporate Developments III-4 Key Players.............. III-7 B.Market Analytics..............III-11 Table 18: US Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-11

Table 19: US Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-12

Table 20: US 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart).............. III-13

2. CANADA.............. III-14 A.Market Analysis.............. III-14 Current & Future Analysis..............III-14 Canada - A Lucrative Biopharmaceutical Industry III-14 Key Player.............. III-15 B.Market Analytics..............III-16 Table 21: Canadian Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-16

Table 22: Canadian Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-17

Table 23: Canadian 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart).............. III-18

3. JAPAN.............. III-19 A.Market Analysis.............. III-19 Current & Future Analysis..............III-19 Key Player.............. III-19 B.Market Analytics..............III-20 Table 24: Japanese Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-20

Table 25: Japanese Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-21

Table 26: Japanese 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart).............. III-22

4. EUROPE.............. III-23 A.Market Analysis.............. III-23 Current & Future Analysis..............III-23 Select Trends in the European Biopharmaceutical Industry III-23 Funding Challenges Faced by Biopharmaceutical Startups III-23 Healthcare Agencies Looking to Embrace Biosimilars to Cut Healthcare Costs..............III-24 B.Market Analytics..............III-25 Table 27: European Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Geographic Region - France, Germany, Italy, UK, Spain, Russia and Rest of European Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart) III-25

Table 28: European Historic Review for Biopharmaceutical Bioseparation Systems by Geographic Region - France, Germany, Italy, UK, Spain, Russia and Rest of European Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart)..............III-26

Table 29: European 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Geographic Region - Percentage Breakdown of Revenues for France, Germany, Italy, UK, Spain, Russia and Rest of European Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart) III-27

Table 30: European Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-28

Table 31: European Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-29

Table 32: European 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart).............. III-30

4a. FRANCE.............. III-31 A.Market Analysis.............. III-31 Current & Future Analysis..............III-31 Key Player.............. III-31 B.Market Analytics..............III-32 Table 33: French Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-32

Table 34: French Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-33

Table 35: French 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart).............. III-34

4b. GERMANY.............. III-35 A.Market Analysis.............. III-35 Current & Future Analysis..............III-35 Key Players.............. III-35 B.Market Analytics..............III-37 Table 36: German Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-37

Table 37: German Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-38

Table 38: German 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart).............. III-39

4c. ITALY.............. III-40 Market Analysis.............. III-40 Table 39: Italian Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-40

Table 40: Italian Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-41

Table 41: Italian 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart).............. III-42

4d. THE UNITED KINGDOM..............III-43 A.Market Analysis.............. III-43 Current & Future Analysis..............III-43 Strategic Corporate Developments III-43 Key Player.............. III-43 B.Market Analytics..............III-44 Table 42: UK Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-44

Table 43: UK Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-45

Table 44: UK 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart).............. III-46

4e. SPAIN.............. III-47 A.Market Analysis.............. III-47 Current & Future Analysis..............III-47 Key Player.............. III-47 B.Market Analytics..............III-48 Table 45: Spanish Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-48

Table 46: Spanish Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-49

Table 47: Spanish 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart).............. III-50

4f. RUSSIA.............. III-51 A.Market Analysis.............. III-51 Current & Future Analysis..............III-51 Russia Sets Eyes on Emerging as a Notable Pharmaceutical Industry.............. III-51 Encouragement for Local Manufacturing to Drive Demand III-51 Challenges - Need for Extensive R&D III-52 B.Market Analytics..............III-53 Table 48: Russian Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-53

Table 49: Russian Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-54

Table 50: Russian 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart).............. III-55

4g. REST OF EUROPE.............. III-56 Market Analysis.............. III-56 Table 51: Rest of Europe Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-56

Table 52: Rest of Europe Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart).............. III-57

Table 53: Rest of Europe 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart) III-58

5. ASIA-PACIFIC.............. III-59 A.Market Analysis.............. III-59 Current & Future Analysis..............III-59 Regional Biopharma Players Gain Strength by Innovation and Partnerships.............. III-59 Asia Set to Emerge as Preferred Outsourcing Destination for Biopharma Manufacturing..............III-59 Availability of Scientific Talent - Major Advantage for India III-60 B.Market Analytics..............III-61 Table 54: Asia-Pacific Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Geographic Region - China, India and Rest of Asia-Pacific Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart)..............III-61

Table 55: Asia-Pacific Historic Review for Biopharmaceutical Bioseparation Systems by Geographic Region - China, India and Rest of Asia-Pacific Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-62

Table 56: Asia-Pacific 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Geographic Region - Percentage Breakdown of Revenues for China, India and Rest of Asia-Pacific Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart) III-63

Table 57: Asia-Pacific Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-64

Table 58: Asia-Pacific Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-65

Table 59: Asia-Pacific 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart) III-66

5a. CHINA.............. III-67 Market Analysis.............. III-67 Table 60: Chinese Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-67

Table 61: Chinese Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-68

Table 62: Chinese 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart).............. III-69

5b. INDIA.............. III-70 Market Analysis.............. III-70 Table 63: Indian Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-70

Table 64: Indian Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-71

Table 65: Indian 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart).............. III-72

5c. REST OF ASIA-PACIFIC..............III-73 A.Market Analysis.............. III-73 Current & Future Analysis..............III-73 Strategic Corporate Development III-73 Key Player.............. III-73 B.Market Analytics..............III-74 Table 66: Rest of Asia-Pacific Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-74

Table 67: Rest of Asia-Pacific Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart).............. III-75

Table 68: Rest of Asia-Pacific 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart) III-76

6. MIDDLE EAST & AFRICA.............. III-77 Market Analysis.............. III-77 Table 69: Middle East & African Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart)..............III-77

Table 70: Middle East & African Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart).............. III-78

Table 71: Middle East & African 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart) III-79

7. LATIN AMERICA.............. III-80 Market Analysis.............. III-80 Table 72: Latin American Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Geographic Region - Brazil and Rest of Latin American Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart)..............III-80

Table 73: Latin American Historic Review for Biopharmaceutical Bioseparation Systems by Geographic Region - Brazil and Rest of Latin American Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-81

Table 74: Latin American 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Geographic Region - Percentage Breakdown of Revenues for Brazil and Rest of Latin American Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart)..............III-82

Table 75: Latin American Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-83

Table 76: Latin American Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart).............. III-84

Table 77: Latin American 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart) III-85

7a. BRAZIL.............. III-86 Market Analysis.............. III-86 Table 78: Brazilian Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-86

Table 79: Brazilian Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart) III-87

Table 80: Brazilian 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart) III-88

7b. REST OF LATIN AMERICA..............III-89 Market Analysis.............. III-89 Table 81: Rest of Latin American Recent Past, Current & Future Analysis for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2014 through 2020 (includes corresponding Graph/Chart)..............III-89

Table 82: Rest of Latin American Historic Review for Biopharmaceutical Bioseparation Systems by Segment - Chromatography Systems and Other Systems Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2010 through 2013 (includes corresponding Graph/Chart).............. III-90

Table 83: Rest of Latin American 11-Year Perspective for Biopharmaceutical Bioseparation Systems by Segment - Percentage Breakdown of Revenues for Chromatography Systems and Other Systems Markets for Years 2010, 2015 & 2020 (includes corresponding Graph/Chart) III-91

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 52 (including Divisions/Subsidiaries - 60)

The United States (32) Canada (1) Japan (5) Europe (18) - France (3) - Germany (9) - The United Kingdom (1) - Spain (1) - Rest of Europe (4) Asia-Pacific (Excluding Japan) (4)
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