Brain Cancer Drug Pipeline Update 2012

NEW YORK, July 16, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Brain Cancer Drug Pipeline Update 2012 http://www.reportlinker.com/p0284911/Brain-Cancer-Drug-Pipeline-Update-2012.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_and_Medication

Despite the heavy investment made into brain cancer research, primary brain cancer, with glioblastoma multiforme being the most aggressive and most common form, remains one of the most deadly diseases in the developed world. While primary brain tumors are relatively rare, the chances of survival for patients with the disease are very low, even with the best treatment options currently available.

There are today 191 companies plus partners developing 194 drugs targeting brain cancer in development. In addition, there are 3 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 68 drugs. Brain Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 131 different targets. These targets are further categorized on in the software application by 45 classifications of molecular function and with pathway referrals to BioCarta, KEGG and NetPath.

How May Drug Pipeline Update Be of Use?* Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.

Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance

Investigators

Includes more than 191 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.

Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.

Drug name & Synonyms

Lists commercial, generic and code names for drugs.

Developmental stageThis Drug Pipeline Update contains 194 drugs in development for the treatment of brain cancer. In addition there are suspended and ceased drugs.

Pipeline Breakdown According to Number of Drugs

Marketed# 11

Pre-registration# 1

Phase III# 11

Phase II# 76

Phase I# 31

Preclinical# 64

Suspended# 3

Ceased# 68

Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

Included brain cancer drugs are also in development for 170 other indications, where of 75 are different cancer indications.

Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

Identified drugs are linked to more than 131 different targets, divided into 45 classifications of molecular function:

- Auxiliary transport protein activity

- Catalytic activity

- Cell adhesion molecule activity

- Chaperone activity

- Complement activity

- Cysteine-type peptidase activity

- Cytokine activity

- DNA binding

- DNA repair protein

- DNA topoisomerase activity

- DNA-directed DNA polymerase activity

- Extracellular ligand-gated ion channel activity

- Extracellular matrix structural constituent

- G-protein coupled receptor activity

- Growth factor activity

- Ion channel activity

- Kinase activity

- Kinase regulator activity

- Ligand-dependent nuclear receptor activity

- Ligase activity

- Lipid kinase activity

- Lipid phosphatase activity

- Molecular function unknown

- Oxidoreductase activity

- Peptidase activity

- Protein binding

- Protein serine/threonine kinase activity

- Protein-tyrosine kinase activity

- Receptor activity

- Receptor binding

- Receptor signaling complex scaffold activity

- Receptor signaling protein serine/threonine kinase activity

- Receptor signaling protein tyrosine phosphatase activity

- RNA binding

- RNA-directed DNA polymerase activity

- Structural constituent of cytoskeleton

- Sugar-phosphatase activity

- Transcription factor activity

- Transcription regulator activity

- Transferase activity

- Translation regulator activity

- Transmembrane receptor activity

- Transmembrane receptor protein tyrosine kinase activity

- Transporter activity

- Voltage-gated ion channel activity

Identified targets are categorized into 19 different primary and alternate sub-cellular localizations:- Cell surface- Centrosome- Clathrin-coated vesicle- Cytoplasm- Cytoplasmic vesicle- Cytosol- Endoplasmic reticulum- Endosome- Extracellular- Golgi apparatus- Integral to membrane- Lysosome- Mitochondrial membrane- Mitochondrion- Nucleolus- Nucleus- Peroxisome- Plasma membrane- Secreted

Note: You are able to find and sort drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.

Target Expression ProfileDirect links are provided from inside the application to 186 protein expression profiles of 113 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:- 48 different normal tissue types- 20 different types of cancer- 47 cell lines- 12 samples of primary blood cells

Pathway Referals

Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG and NetPath.

- BioCarta# 213 Pathways

- KEGG# 97 Pathways

- NetPath# 25 Signaling Pathways

Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

In total there are different drug mechanism of action represented in this Drug Pipeline Update.

Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

Identified drug compounds are described by:

Compound type, Chemical name, CAS Number and molecular weight

Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:

Drug Name & Synonyms

Presentation of drug name and synonyms

Principal Investigator & PartnersPresentation of principal investigator and partners

Target and Molecular Function of Target

Described target(s) is/are presented with:

Official Gene Symbol – Official Gene Name [Species/Homo Sapiens] – Molecular Function

Target LocalizationDescribed target(s) is/are presented with primary and alternate localizations.Target Expression ProfilesLinks to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:48 different normal tissue types20 different types of cancer47 cell lines12 samples of primary blood cells

Targeted Pathways

Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.

MechanismDrug mechanism of action

Developmental Projects

Summary field of developmental projects for the drug, including indication, developmental stage and status.

Example:

Cancer, myeloma – Phase II Clinical Trial – Active

Cancer, prostate – Phase III Clinical Trial – Ceased

Drug DescriptionShort introduction to drug

Compound Data

Compound type, Chemical name, CAS Number and molecular weight

Patent DataAvailable patent information related to the drug is presented here.

Business & Markets

Collaborations and deals

Approvals and submissions

Analyst comments

Phase III DataAvailable Phase III development data, developmental history and scientific data.

Phase II Data

Available Phase II development data, developmental history and scientific data.

Phase I DataAvailable Phase I development data, developmental history and scientific data.

Preclinical Data

Available preclinical development data, developmental history and scientific data.

Licensing InformationAvailability for licensing

Application Features

Use 13 different parameters, available in drop-down menus, to find and sort among drugs

- Drug status

- Clinical Trial Status

- Principle Investigator

- Partners

- Indication

- Developmental Stage

- Compound Type

- Mechanism

- Target

- Molecular Function of Target

- Target Localization

- Targeted Pathways

- Free text search of entire drug profile contents

Direct linkage from inside the application to related internet resources- Drug data is linked to search engines like Google and PubMed- Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath- Direct links to company web pages of principal investigators

Dynamic Report Generator

Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.

System Requirements- Operating system: Windows (2000/XP/Vista/7) and Mac OS X 10.6 (Snow Leopard) and OS X 10.7 (Lion)- Browser Application (Internet Explorer)- Internet access (to access related internet resources)

To order this report: Drug and Medication Industry: Brain Cancer Drug Pipeline Update 2012

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