Bioactive Materials: Technologies and Global Markets

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Oct 09, 2013, 06:45 ET

NEW YORK, Oct. 9, 2013 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Bioactive Materials: Technologies and Global Markets

http://www.reportlinker.com/p01658934/Bioactive-Materials-Technologies-and-Global-Markets.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biomaterial

STUDY GOALS AND OBJECTIVES

BCC began tracking the bioactive materials market in 2006. Since then, the market has been growing at a fairly rapid rate, primarily driven by increasing demand for synthetic materials for tissue replacement in medical applications.With this study, BCC Research continues its commitment to monitoring the bioactive materials market by providing an updated review of the most important advances in bioactive material technology and fabrication methods and offering a detailed overview of the current market, including a quantitative and objective analysis of prospects for future growth.Specifically, the major objectives of this study are to:• Provide an updated review of bioactive material, focusing on materials and fabrication technologies.• Highlight new technological developments during the past three years, while outlining current technical issues.• Identify current and emerging applications for bioactive materials.• Estimate current global markets for bioactive materials by type, product shape, application and region, with growth forecasts through 2018 for each market segment.• Identify important technology and industry trends within each market segment.• Offer an updated review of current industry players, including manufacturers of bioactive materials, technology developers and future market participants.• Provide a description of the most relevant research and development activities.• Determine trends in recently issued U.S. patents.

REASONS FOR DOING THIS STUDY

Bioactive materials represent a category of biomaterials materials that react with body tissues and fluids without adverse reactions in the body. They can be made from different types of materials, such as ceramics, glass, glass-ceramics and composites.While the global biomaterials market is currently quite large, estimated to reach revenues of approximately $50 billion in 2013, the share represented by bioactive materials is a relatively small fraction of this market (less than 2%); however, it represents one of the fastest growing segments, with double-digit growth forecast through 2018.The increased market penetration of these materials is attributed to different factors, including, for example, a rising demand for tissue replacement materials needed in surgical procedures used to treat a rapidly growing elderly population.The principal objective of this report is to present a current assessment of the bioactive materials industry from both a technological and market point of view and to outline future trends and key developments.There is also a need to evaluate the current status and future trends of this market from a global standpoint. As the use of these products expands and new fields of application emerge, information on the suppliers and developers of bioactive materials and their regional distribution becomes more valuable.An equally important reason for undertaking this report is to provide technical insights into the manufacturing of bioactive materials by:• Providing a review of materials, applications and production methods.• Identifying current technical trends.• Providing an overview of the main global R&D activities related to bioactive materials, resulting in the issuance of patents.• Illustrating the latest technological developments.

This information can assist companies in identifying opportunities for process and productivity improvements and new product development, resulting in a positive impact on future market growth.

INTENDED AUDIENCE

This study will be of primary interest to all organizations that:

• Manufacture, sell and distribute bioactive materials and other biomaterials.

• Supply raw materials for the production of bioactive materials.

• Manufacture process equipment utilized during fabrication of bioactive materials.

• Utilize bioactive materials for dental and medical care, cosmetic and pharmaceutical products, food packaging, antibacterial items and other products.

• Provide technical and/or marketing services in conjunction with the above mentioned products.

• Are planning to enter the bioactive materials industry as a supplier, manufacturer or end user.

Overall, this report applies to industry segments such as medicine/surgery, dentistry/periodontics, bioengineering, pharmaceuticals, cosmetics/personal care and packaging.The report is mainly directed toward executives, directors, surgeons, dentists, healthcare professionals, production managers, sales and marketing managers, and strategic planners working within the above industries. Universities and research facilities may also find this report to be a good source of technical information regarding bioactive materials, fabrication processes and applications, which can be used as a baseline for new or expanded R&D activities. Librarians of technical information and research centers can also use this report to provide critical data to healthcare personnel, product managers, market analysts, researchers and other professionals needing detailed and updated insights into the bioactive materials industry.

SCOPE OF REPORT

This report provides an updated review of bioactive materials and their production processes and identifies current and emerging applications for this technology.BCC Research delineates the current market status for bioactive materials, defines trends and presents growth forecasts for the next five years. Market analysis is based on the following segments: material type, product shape, application and region. In addition, technological issues, including key events and the latest process developments, are also discussed.More specifically, BCC's market analysis is divided into five sections.In the first section, an introduction to the topic and a historical review of bioactive materials are provided, including an outline of recent events. In this section, current and emerging applications for bioactive materials are also identified and described.The second section provides a technological review of the various types of bioactive materials and their fabrication methods, with a focus on materials of recent development and innovative production processes. The most important technological developments since 2010 are described, including examples of significant patents recently issued and patent applications recently filed. This section concludes by highlighting the most active research organizations operating in this field.The third section presents a global market analysis of bioactive materials. Global revenues (sales data in millions of dollars) are presented for each segment (material type, product shape, application and region) with actual data for the years 2011 and 2012 and estimated revenues for 2013. The analysis of current revenues for bioactive materials is followed by a detailed presentation of market growth trends, based on industry growth, technological trends and regional trends. The third section concludes by providing projected revenues for bioactive materials within each segment, together with forecast compound annual growth rates (CAGRs) for 2013 through 2018.In the fourth section of the study, which covers the global industry structure, the report offers a list of the leading manufacturers of bioactive materials, together with a description of their products. The analysis includes a description of the geographical distribution of these suppliers and an evaluation of other key industry players. Detailed company profiles of the top players are also provided.The fifth and final section includes an extensive U.S. patent analysis, with a summary of patents related to bioactive materials and their fabrication methods and applications. The patents examined in this study were issued from 2011 through 2013. Patent analysis is performed by region, country, assignee, patent category, application and material type.

METHODOLOGY AND INFORMATION SOURCES

To analyze the overall market and market segments, both primary and secondary research methodologies were used to obtain market data.The technology section of this report is based on information derived from technical literature, related BCC reports, professional journals, the author's field experience and online sources.Global market analysis was performed by a thorough investigation of manufacturers of bioactive materials, raw material suppliers, producers of equipment used in manufacturing and testing these materials, and developers of new technologies, accounting for at least 90% of the global market. Data were obtained from the direct contribution of primary sources, including company executives, managers, engineers and other technical personnel representing manufacturers, developers and users of bioactive materials and related technologies; representatives of academia and trade associations; and industry market analysts.Additional data for each company were obtained by thoroughly analyzing Security and Exchange Commission (SEC) filings, websites, annual reports, industry directories, industry magazines and catalogs, government sources and other public sources.Secondary sources of information include but are not limited to:• U.S. Securities and Exchange Commission filings.• U.S. Patent and Trademark Office.• European Patent Office.• Company websites.• Company annual reports.• Thomas Register.• Moody's Directory.• S&P Industry Survey.• Dun & Bradstreet Business Directory.• Foreign Chamber of Commerce Directories.• Foreign stock exchange listings.• American Ceramic Society Publications.• American Chemical Society Publications.

In addition to utilizing the above primary and secondary sources, market growth trends and forecasts were compiled by gaining additional insights from relevant financial and market information, relevant BCC reports and the author's own in-depth and comprehensive analysis of the collected information.

REPORT HIGHLIGHTS

This report provides:

• Descriptions of various types of bioactive materials (i.e., glasses, glass-ceramics, ceramics, and composites), including biological materials such as proteins and enzymes; their fabrication methods (including variants and upgrades); and identification of current and potential applications for each type

• Analyses of the industry on a worldwide basis from the standpoint of both manufacturing and consumption, with data for 2011 and 2012, estimates for 2013, and projections of compound annual growth rates (CAGRs) through 2018

• Examinations of commercial and public research activities in major regions of the world

• Comprehensive profiles of the top companies in the industry

• An in-depth patent analysis.

TABLE OF CONTENTS

CHAPTER 1 INTRODUCTION 2

STUDY GOALS AND OBJECTIVES 2

REASONS FOR DOING THIS STUDY 2

INTENDED AUDIENCE 3

SCOPE OF REPORT 4

METHODOLOGY AND INFORMATION SOURCES 4

ANALYST CREDENTIALS 5

RELATED BCC RESEARCH STUDIES 6

BCC ONLINE SERVICES 7

DISCLAIMER 7

CHAPTER 2 EXECUTIVE SUMMARY 9

SUMMARY TABLE GLOBAL MARKET FOR BIOACTIVE MATERIALS, THROUGH 2018 ($

MILLIONS) 10

SUMMARY FIGURE GLOBAL MARKET FOR BIOACTIVE MATERIALS, 2011-2018 ($

MILLIONS) 10

CHAPTER 3 OVERVIEW 12

BIOMATERIALS, BIOACTIVE MATERIALS AND THE BIOMATERIALS INDUSTRY 12

BIOMATERIALS AND BIOACTIVE MATERIALS 12

TABLE 1 CLASSIFICATION OF BIOMATERIALS 13

THE BIOMATERIALS INDUSTRY 13

TABLE 2 THE BIOMATERIAL MARKET BY REGION, 2013 ($ BILLIONS/%) 14

MILESTONES IN THE HISTORY OF BIOMATERIALS AND BIOACTIVE MATERIALS

AND RECENT EVENTS 14

TABLE 3 BIOMATERIALS AND BIOACTIVE MATERIALS-TECHNOLOGICAL MILESTONES 14

FIGURE 1 BIOACTIVE MATERIALS-WORLDWIDE PATENT APPLICATIONS AND

PATENTS ISSUED SINCE 1970 (NO.) 15

APPLICATIONS OF BIOACTIVE MATERIALS 17

TABLE 4 APPLICATIONS OF BIOACTIVE MATERIALS, 2013 17

TISSUE REPLACEMENT AND REPAIR 18

Autografts 18

Allografts 18

Xenografts 18

Synthetic Materials 19

IMPLANTS 19

OTHER EMERGING APPLICATIONS IN THE MEDICAL SECTOR 19

DENTISTRY AND PERIODONTICS 19

BIOENGINEERING 20

PHARMACEUTICALS AND OTHERS 20

CHAPTER 4 TECHNOLOGY 22

INTRODUCTION 22

BIOACTIVE MATERIALS 22

MATERIAL TYPES 22

TABLE 5 BIOACTIVE MATERIALS, 2013 22

BIOACTIVE GLASS 25

45S5 Bioglass 25

TABLE 6 COMPOSITION OF 45S5 BIOGLASS VERSUS COMMERCIAL GLASS (% BY

WEIGHT) 25

Reaction Mechanism of Bioglass 26

Other Bioactive Glasses 27

TABLE 7 TYPICAL COMPOSITIONS OF BIOACTIVE GLASS (% BY WEIGHT) 27

BIOACTIVE GLASS-CERAMICS 28

A-W Glass-Ceramic 28

Bioverit 29

Ceravital 29

New-Generation Glass-ceramics 29

BIOACTIVE CERAMICS 30

Hydroxyapatite 30

Tricalcium Phosphate 30

Beta-Tricalcium Phosphate 30

Alpha-Tricalcium Phosphate 31

Tetracalcium Phosphate 31

Other Bioactive Ceramics 31

Biphasic Bioactive Ceramics 31

BIOACTIVE COMPOSITES 31

Polymer Matrix Composites 32

High-Density Polyethylene/Hydroxyapatite 32

High-Density Polyethylene/A-W glass-ceramic 32

High-Density Polyethylene/Bioglass 32

Polysulfone/Ceramic 33

Biodegradable Polymer/Ceramic 33

Acrylic Polymer/Ceramic 33

Polylactic Acid/Ceramic 34

Ceramic Matrix Composites 34

Metal Matrix Composites 34

LATEST TECHNOLOGICAL DEVELOPMENTS, 2010 TO PRESENT 34

PEEK/Bioactive Glass-ceramic Composite 34

Borate-Base Bioactive Glass for Wound Healing 35

Bioactive Glass with Fluoride 36

Bioactive Gelatin/Graphene Oxide Nanocomposite 36

Bioactive Ceramic Nanocomposite based on Zirconia and Alumina 37

Clay-Based Bioactive Materials 37

Other Relevant Bioactive Materials of Recent Development 38

PRODUCTION METHODS 39

TABLE 8 BIOACTIVE MATERIALS: TRADITIONAL FABRICATION METHODS, 2013 39

MELTING 39

SOL-GEL 40

TABLE 9 TYPICAL COMPOSITIONS OF BIOACTIVE GLASS MADE BY THE SOL-GEL

METHOD (% BY WEIGHT) 41

SPECIALTY PROCESSES FOR GLASS AND GLASS-CERAMICS 41

MILLING AND SINTERING 42

SPRAY-DRYING 42

PLASTIC PROCESSING 43

IMPREGNATION 43

LATEST TECHNOLOGICAL DEVELOPMENTS, 2010 TO PRESENT 43

Bioactive Glass Scaffold Manufactured by Robocasting 43

Bioactive Ceramic/Polymer Composite by Electrospinning 44

Polymer/Bioactive Ceramic Composite by Spray Drying or

Precipitation 44

Three-Dimensional Printing of Bioactive Glass/Hydroxyapatite

Scaffolds 45

Fabrication of Hydroxyapatite/Zirconia Composite by Microwave

Sintering 45

Bioactive Glass-Ceramic Manufactured By Melt-Quench Process 46

OTHER RELEVANT R&D ACTIVITIES 46

TABLE 10 OTHER RELEVANT R &D ACTIVITIES, 2013 47

CHAPTER 5 GLOBAL MARKETS 50

ANALYSIS OUTLINE 50

GLOBAL MARKET SUMMARY 50

TABLE 11 GLOBAL MARKET FOR BIOACTIVE MATERIALS, THROUGH 2018 ($

MILLIONS) 51

FIGURE 2 GLOBAL MARKET FOR BIOACTIVE MATERIALS, 2011-2018 ($ MILLIONS) 51

CURRENT MARKET STATUS 52

CURRENT MARKET SUMMARY 52

TABLE 12 GLOBAL MARKET FOR BIOACTIVE MATERIALS, THROUGH 2013 ($

MILLIONS) 53

FIGURE 3 GLOBAL MARKET FOR BIOACTIVE MATERIALS, 2011-2013 ($ MILLIONS) 53

REVENUES BY MATERIAL TYPE 53

TABLE 13 BIOACTIVE MATERIALS: GLOBAL REVENUES BY MATERIAL TYPE,

THROUGH 2013 ($ MILLIONS) 54

FIGURE 4 BIOACTIVE MATERIALS: MARKET SHARE BY MATERIAL TYPE, 2013 (%) 55

TABLE 14 BIOACTIVE CERAMICS: GLOBAL REVENUES BY CERAMIC TYPE, 2013 ($

MILLIONS/%) 55

TABLE 15 BIOACTIVE COMPOSITES: GLOBAL REVENUES BY COMPOSITE TYPE, 2013

($ MILLIONS/%) 56

REVENUES BY PRODUCT SHAPE 56

TABLE 16 BIOACTIVE MATERIALS: GLOBAL REVENUES BY PRODUCT SHAPE,

THROUGH 2013 ($ MILLIONS) 57

FIGURE 5 BIOACTIVE MATERIALS: MARKET SHARE BY PRODUCT SHAPE, 2013 (%) 57

REVENUES BY APPLICATION 58

TABLE 17 BIOACTIVE MATERIALS: GLOBAL REVENUES BY APPLICATION, THROUGH

2013 ($ MILLIONS) 58

FIGURE 6 BIOACTIVE MATERIALS: MARKET SHARE BY APPLICATION, 2013 (%) 58

REVENUES BY REGION 59

TABLE 18 BIOACTIVE MATERIALS: REVENUES BY REGION, THROUGH 2013 ($

MILLIONS) 60

FIGURE 7 BIOACTIVE MATERIALS: MARKET SHARE BY REGION, 2013 (%) 60

MARKET GROWTH TRENDS 61

INDUSTRY GROWTH AND TECHNOLOGICAL TRENDS 61

Cranio-maxillofacial Surgery 61

Spinal and Orthopedic Bone Grafting Procedures 61

TABLE 19 FORECAST—VERTEBRAL AND ORTHOPEDIC BONE GRAFTS AND BONE

GRAFTS REPLACEMENTS: REVENUES BY REGION, THROUGH 2018 ($ MILLIONS) 62

Orthopedic Implants 62

TABLE 20 FORECAST-ORTHOPEDIC IMPLANTS: REVENUES BY REGION, THROUGH

2018 ($ BILLIONS) 63

Dentistry/Periodontics 63

Cosmetics and Personal Care 63

Others 64

Tissue Engineering Scaffolds 64

Wound Treatment Products 65

Specialty Materials for Food Packaging 65

TECHNOLOGICAL TRENDS 65

Orthobiologics and Biologics 65

Materials with Enhanced Bioactivity 66

Nanotechnology 66

TABLE 21 THE NANOTECHNOLOGY INDUSTRY, 2013 67

TABLE 22 NANOTECHNOLOGY: GLOBAL REVENUES BY SEGMENT, THROUGH 2018

($ BILLIONS) 68

FIGURE 8 NANOTECHNOLOGY: GLOBAL MARKET SHARE BY SEGMENT, 2013 (%) 69

REGIONAL TRENDS 69

MARKET FORECAST 70

REVENUES BY MATERIAL TYPE 70

TABLE 23 FORECAST-BIOACTIVE MATERIALS: GLOBAL REVENUES BY MATERIAL

TYPE, THROUGH 2018 ($ MILLIONS) 71

FIGURE 9 FORECAST-BIOACTIVE MATERIALS: MARKET SHARE BY MATERIAL TYPE,

2018 (%) 71

TABLE 24 FORECAST-BIOACTIVE CERAMICS: GLOBAL REVENUES BY CERAMIC TYPE,

THROUGH 2018 ($ MILLIONS) 72

TABLE 25 FORECAST-BIOACTIVE COMPOSITES: GLOBAL REVENUES BY COMPOSITE

TYPE, THROUGH 2018 ($ MILLIONS) 72

REVENUES BY PRODUCT SHAPE 72

TABLE 26 FORECAST-BIOACTIVE MATERIALS: GLOBAL REVENUES BY PRODUCT

SHAPE, THROUGH 2018 ($ MILLIONS) 73

FIGURE 10 FORECAST-BIOACTIVE MATERIALS: MARKET SHARE BY PRODUCT SHAPE,

2018 (%) 73

REVENUES BY APPLICATION 74

TABLE 27 FORECAST-BIOACTIVE MATERIALS: GLOBAL REVENUES BY APPLICATION,

THROUGH 2018 ($ MILLIONS) 75

FIGURE 11 FORECAST—BIOACTIVE MATERIALS: MARKET SHARE BY APPLICATION,

2018 (%) 75

REVENUES BY REGION 76

TABLE 28 FORECAST-BIOACTIVE MATERIALS: REVENUES BY REGION, THROUGH

2018 ($ MILLIONS) 76

FIGURE 12 FORECAST-BIOACTIVE MATERIALS: MARKET SHARE BY REGION, 2018

(%) 77

CHAPTER 6 GLOBAL INDUSTRY STRUCTURE 79

LEADING MANUFACTURERS OF BIOACTIVE MATERIALS 79

TABLE 29 LEADING MANUFACTURERS OF BIOACTIVE MATERIALS, 2013 79

TABLE 30 LEADING MANUFACTURERS OF BIOACTIVE MATERIALS BY TYPE, 2013 82

TABLE 31 LEADING SUPPLIERS OF BIOACTIVE MATERIALS, BY TYPE AND REGION,

2013 85

OTHER PLAYERS IN THE BIOACTIVE MATERIAL INDUSTRY 85

TABLE 32 OTHER RELEVANT INDUSTRY PLAYERS, 2013 85

COMPANY PROFILES 86

3DI 86

AAP IMPLANTATE 87

ARTHREX 88

BAXTER/APATECH 88

BERKELEY ADVANCED BIOMATERIALS 89

BIOCOMPOSITES 90

BIOMATLANTE 90

BIOMET 91

CAM BIOCERAMICS 93

CERAVER 93

CURASAN 94

DENTSPLY INTERNATIONAL 95

DEPUY SYNTHES 96

DOT 97

HERAEUS KULZER 98

HOYA/PENTAX NEW CERAMICS 98

INTEGRA LIFE SCIENCES 99

KYOCERA 100

MEDTRONIC 101

NOVABONE PRODUCTS 102

SCHOTT 103

STRYKER 103

TAKIRON 105

WRIGHT MEDICAL TECHNOLOGY 105

ZIMMER 106

CHAPTER 7 U.S. PATENT ANALYSIS 109

INTRODUCTION 109

SUMMARY OF PATENTS AWARDED FROM 2011 THROUGH 2013 109

TABLE 33 BIOACTIVE MATERIALS-U.S. PATENTS, 2013 109

TABLE 34 BIOACTIVE MATERIALS-U.S. PATENTS, 2012 112

TABLE 35 BIOACTIVE MATERIALS—U.S. PATENTS, 2011 115

GENERAL TRENDS 117

TABLE 36 BIOACTIVE MATERIALS: U.S. PATENT TRENDS, 2011-2013 VS. 2004-2006

(NUMBER OF PATENTS) 118

FIGURE 13 BIOACTIVE MATERIALS: U.S. PATENT TRENDS, 2011-2013 (NUMBER OF

PATENTS) 118

TRENDS BY COUNTRY AND REGION 119

FIGURE 14 BIOACTIVE MATERIALS: SHARES OF U.S. PATENTS BY REGION,

2011-2013 (%) 120

FIGURE 15 BIOACTIVE MATERIALS: U.S. PATENTS BY COUNTRY, 2011-2013 (NO. OF

PATENTS) 121

TRENDS BY ASSIGNEE 121

TABLE 37 BIOACTIVE MATERIALS: ASSIGNEES OF U.S. PATENTS, 2011-2013 122

FIGURE 16 BIOACTIVE MATERIALS: SHARES OF U.S. PATENTS BY ORGANIZATION

TYPE, 2011-2013 (%) 124

TRENDS BY PATENT CATEGORY 125

FIGURE 17 BIOACTIVE MATERIALS: SHARES OF U.S. PATENTS BY CATEGORY,

2011-2013 (%) 126

TRENDS BY APPLICATION 126

FIGURE 18 BIOACTIVE MATERIALS: SHARES OF U.S. PATENTS BY APPLICATION,

2011-2013 (%) 127

TRENDS BY MATERIAL TYPE 128

FIGURE 19 BIOACTIVE MATERIALS: SHARES OF U.S. PATENTS BY MATERIAL TYPE,

2011-2013 (%) 128

LIST OF TABLES

SUMMARY TABLE GLOBAL MARKET FOR BIOACTIVE MATERIALS, THROUGH 2018 ($

MILLIONS) 10

TABLE 1 CLASSIFICATION OF BIOMATERIALS 13

TABLE 2 THE BIOMATERIAL MARKET BY REGION, 2013 ($ BILLIONS/%) 14

TABLE 3 BIOMATERIALS AND BIOACTIVE MATERIALS-TECHNOLOGICAL MILESTONES 14

TABLE 4 APPLICATIONS OF BIOACTIVE MATERIALS, 2013 17

TABLE 5 BIOACTIVE MATERIALS, 2013 22

TABLE 6 COMPOSITION OF 45S5 BIOGLASS VERSUS COMMERCIAL GLASS (% BY

WEIGHT) 25

TABLE 7 TYPICAL COMPOSITIONS OF BIOACTIVE GLASS (% BY WEIGHT) 27

TABLE 8 BIOACTIVE MATERIALS: TRADITIONAL FABRICATION METHODS, 2013 39

TABLE 9 TYPICAL COMPOSITIONS OF BIOACTIVE GLASS MADE BY THE SOL-GEL

METHOD (% BY WEIGHT) 41

TABLE 10 OTHER RELEVANT R &D ACTIVITIES, 2013 47

TABLE 11 GLOBAL MARKET FOR BIOACTIVE MATERIALS, THROUGH 2018 ($

MILLIONS) 51

TABLE 12 GLOBAL MARKET FOR BIOACTIVE MATERIALS, THROUGH 2013 ($

MILLIONS) 53

TABLE 13 BIOACTIVE MATERIALS: GLOBAL REVENUES BY MATERIAL TYPE, THROUGH

2013 ($ MILLIONS) 54

TABLE 14 BIOACTIVE CERAMICS: GLOBAL REVENUES BY CERAMIC TYPE, 2013 ($

MILLIONS/%) 55

TABLE 15 BIOACTIVE COMPOSITES: GLOBAL REVENUES BY COMPOSITE TYPE, 2013

($ MILLIONS/%) 56

TABLE 16 BIOACTIVE MATERIALS: GLOBAL REVENUES BY PRODUCT SHAPE,

THROUGH 2013 ($ MILLIONS) 57

TABLE 17 BIOACTIVE MATERIALS: GLOBAL REVENUES BY APPLICATION, THROUGH

2013 ($ MILLIONS) 58

TABLE 18 BIOACTIVE MATERIALS: REVENUES BY REGION, THROUGH 2013 ($

MILLIONS) 60

TABLE 19 FORECAST—VERTEBRAL AND ORTHOPEDIC BONE GRAFTS AND BONE

GRAFTS REPLACEMENTS: REVENUES BY REGION, THROUGH 2018 ($ MILLIONS) 62

TABLE 20 FORECAST-ORTHOPEDIC IMPLANTS: REVENUES BY REGION, THROUGH

2018 ($ BILLIONS) 63

TABLE 21 THE NANOTECHNOLOGY INDUSTRY, 2013 67

TABLE 22 NANOTECHNOLOGY: GLOBAL REVENUES BY SEGMENT, THROUGH 2018 ($

BILLIONS) 68

TABLE 23 FORECAST-BIOACTIVE MATERIALS: GLOBAL REVENUES BY MATERIAL TYPE,

THROUGH 2018 ($ MILLIONS) 71

TABLE 24 FORECAST-BIOACTIVE CERAMICS: GLOBAL REVENUES BY CERAMIC TYPE,

THROUGH 2018 ($ MILLIONS) 72

TABLE 25 FORECAST-BIOACTIVE COMPOSITES: GLOBAL REVENUES BY COMPOSITE

TYPE, THROUGH 2018 ($ MILLIONS) 72

TABLE 26 FORECAST-BIOACTIVE MATERIALS: GLOBAL REVENUES BY PRODUCT

SHAPE, THROUGH 2018 ($ MILLIONS) 73

TABLE 27 FORECAST-BIOACTIVE MATERIALS: GLOBAL REVENUES BY APPLICATION,

THROUGH 2018 ($ MILLIONS) 75

TABLE 28 FORECAST-BIOACTIVE MATERIALS: REVENUES BY REGION, THROUGH

2018 ($ MILLIONS) 76

TABLE 29 LEADING MANUFACTURERS OF BIOACTIVE MATERIALS, 2013 79

TABLE 30 LEADING MANUFACTURERS OF BIOACTIVE MATERIALS BY TYPE, 2013 82

TABLE 31 LEADING SUPPLIERS OF BIOACTIVE MATERIALS, BY TYPE AND REGION,

2013 85

TABLE 32 OTHER RELEVANT INDUSTRY PLAYERS, 2013 85

TABLE 33 BIOACTIVE MATERIALS-U.S. PATENTS, 2013 109

TABLE 34 BIOACTIVE MATERIALS-U.S. PATENTS, 2012 112

TABLE 35 BIOACTIVE MATERIALS—U.S. PATENTS, 2011 115

TABLE 36 BIOACTIVE MATERIALS: U.S. PATENT TRENDS, 2011-2013 VS. 2004-2006

(NUMBER OF PATENTS) 118

TABLE 37 BIOACTIVE MATERIALS: ASSIGNEES OF U.S. PATENTS, 2011-2013 122

LIST OF FIGURES

SUMMARY FIGURE GLOBAL MARKET FOR BIOACTIVE MATERIALS, 2011-2018 ($

MILLIONS) 10

FIGURE 1 BIOACTIVE MATERIALS-WORLDWIDE PATENT APPLICATIONS AND PATENTS

ISSUED SINCE 1970 (NO.) 15